FrezzaLab

We are a group of metabolism-lovers, focused on mitochondrial metabolism. Tweets are from Christian.

[FrezzaLab @FrezzaLab]

This is a topic I am very passionate about, and something I am learning every day. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic.

The mindful scientist https://t.co/MpBdgf22En #FEBSnet

[FrezzaLab @FrezzaLab]

@donalddhoffman are you recruiting?! 😊 this seems a fantastic initiative!

[FrezzaLab @FrezzaLab]

Good Sunday, all. The last week has seen some amazing papers in #cancermetabolism and #mitochondrialbiology. Here is the summary, don't miss these papers https://t.co/YIcWkOGn89 @Bims_BiomedNews #keepreading

"The universe is wider than our views of it."-Henry David Thoreau

[FrezzaLab @FrezzaLab]

@lars_sandved thank you!

[FrezzaLab @FrezzaLab]

@lars_sandved I love this work! I have a question from a non-expert in the theory of the topic, but a practitioner. Is this somehow conceptually linked to Godel incompleteness?

[FrezzaLab @FrezzaLab]

Good Sunday, mitolovers. There is a fantastic selection of papers in #cancermetabolism and #mitochondrialbiology waiting for you: https://t.co/LK7Wf701by @biomednews #keepreading

"I am not a thing in the world; I am the space in which the world is happening." -Richard Lang

[FrezzaLab @FrezzaLab]

Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite | Nature https://t.co/BQ8KNAabcL

[Kelsey Fisher-Wellman, PhD @KFW_Lab]

New review from our group taking a critical look at OxPhos as a cancer target......and suggestions for where the field goes next. Published in @Biochem_Journal
https://t.co/rwU1AIymEK

[FrezzaLab @FrezzaLab]

Good Sunday, all. Here is an exciting weekly issue of papers in #cancermetabolism and #mitochondrialbiology, curated for you: https://t.co/7ksF9S8iBa @Bims_BiomedNews #keepreading

"And what importance do I have in the courtroom of oblivion?"-Pablo Neruda

[FrezzaLab @FrezzaLab]

@jer_06200 @oncogenesis Thanks JE for giving us this opportunity!

[FrezzaLab @FrezzaLab]

@apoptosislab @jer_06200 @oncogenesis thanks for posting!

[FrezzaLab @FrezzaLab]

@RyanLab_TCD just testing for now 😊

[FrezzaLab @FrezzaLab]

Good Sunday, mitolovers. There is a truly exceptional curated issue of papers in #cancermetabolism and #mitochondrialbiology here: https://t.co/BvS68KYq8d Biomed News. Don't miss it #keepreading

"You have to do nothing to be who you are. Nothing at all."-H. W. L. Poonja

[FrezzaLab @FrezzaLab]

I am following the recent series of pieces "Thinking as a Scientist" with an article on "How to Ask a Biological Question." https://t.co/2hJ2kgBIuJ @FEBSnews
This is often easier said than done, as we receive no formal training in this area.
I look forward to your views.

[FrezzaLab @FrezzaLab]

@Madam_Mito Thanks, I am trying, after some encouragement from peers, let's see!

[FrezzaLab @FrezzaLab]

Good Sunday, all! Here is a fantastic selection of papers in #cancermetabolism and #mitochondrialbiology curated for you 💥 : https://t.co/jLgirdJtXS Biomed News #keepreading

"Wisdom tends to grow in proportion to one's awareness of one's ignorance."-Anthony De Mello

[Iannacone Lab @iannaconelab]

💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) https://t.co/OA0TCnmF7R

🔬Approach: We used a subcutaneous LCMV infection model, tracking virus-specific CD4⁺ T cells. Surprisingly, we found two T-bet⁺ subsets—one producing granzyme B (GzmB) and another expressing Tcf-1, the latter being a TFHprecursor. (2/10)

🌟Key Finding: IFN-γ from T cells drives the TH1 fate and blocks TFHmaturation. When we blocked IFN-γ early, Tcf-1⁺ “precursor” cells fully developed into TFH, boosting germinal center B cells and antibody responses. (3/10)

📊Mechanism: Rather than acting solely via an “autocrine loop,” IFN-γ shapes the microenvironment by acting on other immune cells—likely dendritic cells—thereby steering CD4⁺ T cells toward a TH1-dominant response at the expense of TFH. (4/10)

📌Infections & Vaccines: We also tested other settings—like systemic infections or even MPLA-based immunizations—and consistently observed that reducing IFN-γ can enhance TFH and humoral immunity. Timing is critical for optimal effect. (5/10)

🧬Broader Impact: Our data help explain why some infections trigger robust TH1activity but limited antibody responses, and highlight how precisely timed IFN-γ modulation could improve immunization strategies. (6/10)

🔑Clinical Relevance: In severe or chronic viral infections, TH1-skewed responses can sometimes block high-affinity antibody production. Targeted IFN-γ blockade might tip the balance toward TFH, aiding pathogen clearance or vaccine success. (7/10)

💡Mechanistic Insights: By tuning IFN-γ signals, we can reprogram local lymph nodes and “unlock” TFH potential. This points toward new avenues to combine T cell and B cell–focused therapies for more effective vaccines. (8/10)

👏Huge congratulations to Mirela Kuka, Eleonora Sala, Maria Nelli and all contributors who co-led the study! (9/10)

📖Dive deeper into our research and its implications for antiviral defense and vaccines. We look forward to your thoughts and questions!
Full paper here: https://t.co/OA0TCnmF7R
@SanRaffaeleMI @MyUniSR @ERC_Research @AIRC_it @EMBO @ArmeniseHarvard
(10/10) 💬📚

[FrezzaLab @FrezzaLab]

@PLeippe yes! a significant one.

[FrezzaLab @FrezzaLab]

This is a huge decision from the Guardian. I believe too that X has become a polarised political platform that has lost its purpose and sadly, I no longer support it, despite its initial good intention.
I will move my activity to @frezzalab.bsky.social

https://t.co/aCuwuIOGD6

[FrezzaLab @FrezzaLab]

@shanmugamlab thanks! I am on bluesky

[FrezzaLab @FrezzaLab]

I know firsthand that every platform reaching a certain critical mass will suffer from this issue (as you said, FB, for example), but I don't feel I can support X anymore. Your suggestion is valid, and it is what I tried to do for years here, but if the attacks on science are from people whose only intention is to discredit it, the discussion is no longer balanced, and science will overall lose.

[FrezzaLab @FrezzaLab]

@eric_novack @heniek_htw @elonmusk In fact, I left Facebook many years ago and transitioned to Twitter because of that problem. But again, this is not about political views (I never expressed any here).