Dylan Ryan

Assistant Professor in Trinity College Dublin. A mitochondria and immunometabolism enthusiast.

[Dylan Ryan @RyanLab_TCD]

Very excited to announce that the first paper from the lab is now live @NatureComms #mitochondria #immunometabolism

This work was led by postdoc @EloiseMLMrqs with many important contributions from all of our co-authors.

New insights since the preprint (summarised below):

1) Biphasic IFN-I expression
2) Late phase IFN-I is mediated by mitochondrial nucleic acid signalling incl. cGAS-STING pathway
3) Reduced IL-1 and COX2 is mediated in part by autocrine IFN-I
4) Systemic IFN-I signalling in different tissues, notably the kidney, in vivo

Please check it out!
https://t.co/d8LfHDXEJA

[Luke_Brown_91 @Luke_Brown_91]

Sepsis is a balancing act: too little immunity fails to control infection, too much causes tissue damage. Our @ScienceMagazine paper reveals one mechanism behind this tradeoff.
https://t.co/D0IXKZyjfu

[Dylan Ryan @RyanLab_TCD]

📢 Last 2 weeks of #immunometabolism discoveries brought to you from EUROMIT in sunny Angers Saint-Laud ☀️ @Bims_BiomedNews ⬇️ ⬇️ ⬇️

https://t.co/Nx4oj5VVSy
https://t.co/IhIdP5sUDe

Interesting finding:

Monocyte infiltration induces CNS arginine catabolism to fuel neuroinflammation

[Dylan Ryan @RyanLab_TCD]

We clarify what OxPhos is (and is not), emphasizing why oxygen consumption rate (OCR) is an incomplete surrogate for ATP-producing OxPhos flux and why transcriptomic ‘OxPhos signatures’ often confound energetic demand with compensatory responses to mitochondrial damage. - I have a perfect example of this in my model 🙏 Made me rethink a lot of datasets where they find a high OxPhos signature and how it's interpreted.

[Brett Chrest @Chrest_brett]

📢NEW REVIEW: We introduce the distinction between essentiality and disproportionate essentiality when targeting OxPhos in cancer, and explain why this target does not support a therapeutic window once we consider the rest of the organism.
https://t.co/75Cl8ezvP5

[FrezzaLab @FrezzaLab]

Good Sunday, all. The last week has seen some amazing papers in #cancermetabolism and #mitochondrialbiology. Here is the summary, don't miss these papers https://t.co/YIcWkOGn89 @Bims_BiomedNews #keepreading

"The universe is wider than our views of it."-Henry David Thoreau

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Human haematopoietic stem cells remember inflammatory stress | Nature https://t.co/0PMibNaic7

[Cell Metabolism @Cell_Metabolism]

New! Online now: Iron-addicted colorectal cancers exploit heme-complex II axis to resist oxidative cell death https://t.co/NyFHQMhsAM

[Dylan Ryan @RyanLab_TCD]

@IdoAmitLab Such a wild discovery!

[IdoAmitLab @IdoAmitLab]

For those of you who think macrophages do almost everything, rethink “almost.”
They are programmable cells, recruited into whatever new function evolution needs.
https://t.co/tz6VrVQWpw

[Saligrama lab_WUSTL @SaligramaLab]

This is #wild and #fascinating -"Homing pigeon navigation relies on superparamagnetic macrophages under overcast conditions" https://t.co/OksckAbZlA

[Dylan Ryan @RyanLab_TCD]

@SanchoLab @CellReports @CNIC_CARDIO Congratulations David and team! Really great work again and they keep on coming!

[David Sancho @SanchoLab]

How does oxygen sensing shape alveolar #macrophage (AM) identity?
In our new @CellReports HIF-1α and HIF-2α play distinct, non-redundant roles in AM maturation & function
A #metabolic split that defines macrophage biology in the lung.
OPEN: https://t.co/1pxnHMUWgZ
@CNIC_CARDIO

[nature @Nature]

Nature research paper: Early fossil eukaryotes were benthic aerobes

https://t.co/U7G0SvffFv

[Katherine Aird @airdlab]

It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats @ApoorvaUboveja!
https://t.co/o4ekqG9E4Y

[Tanentzapf Lab @TanentzapfLab]

In the last 15 years we had: first image of a black hole, The LIGO experiment, proof of the Higgs Boson, mRNA Vaccines, CRISPR, AI revolution (especially alpha fold). I could go on. Pushing the narrative that discovery is slowing down is an embarrassment for @TheEconomist

[Cell Biology J-Club @cell_club]

A transport-independent role for SLC25A12 in mitochondrial stress signalling | Nature Cell Biology https://t.co/PDqwPBOOvK

[Eric Topol @EricTopol]

As we age, especially after 60 years, there is a marked accumulation of mutations in our mitochondrial DNA. These are undetected (cryptic) until they expand into clones and, while associated with clonal hematopoiesis (CHIP), they may independently have an impact on health outcomes @Nature
https://t.co/fO9xmSIbDc

[Eric Topol @EricTopol]

Just published @Nature
Very impressive study of gene expression and hallmarks of aging across 4 mammalian species (including humans), by @gladyshev_lab. Transcriptomic clocks add to epigenetic, organ and cellular clocks for predicting health outcomes. Example of a few proteins found with prediction of disease/event risk in Figure below
https://t.co/t3HDtDAfOT

[Marcus Goncalves @MarcusDGon]

Authors used MouseMapper to study diet-induced obesity, and identified structural alterations of the infraorbital branch of the trigeminal ganglia https://t.co/CmdWGMp0aP

[John Lukens @LukensJohnR]

Maternal-fetal type I interferon signaling drives TREM2 dysregulation and synaptic dysfunction in neurodevelopmental disorders @NeuroCellPress https://t.co/GEiIGcOwoR