JJ

Co-founder @QLTINC -

[JJ @JosephJacks_]

In the early 1970s, @StuartHameroff began writing about microtubules as molecular computers. By the mid-1980s, he was writing Ultimate Computing. When the book was published by Elsevier in 1987, it had cited no fewer than 14 scientists who would go on to win Nobel Prizes — in physics, chemistry, and medicine — across the following four decades.

This may be the only book in human history with such profound prescience across so many domains.

Future Nobel laureates in Physics cited:

•Roger Penrose (2020) — cited for his 1957 Nature paper with his father Lionel on self-reproducing mechanical analogues

•John Hopfield (2024) — Hopfield nets discussed across multiple chapters

•Geoffrey Hinton (2024) — Boltzmann machines, parallel associative memory

•David Wineland (2012) — 1986 paper on observing quantum jumps in a single atom

Chemistry future laureates cited:

•Robert Huber (1988) — protein conformational flexibility

•Thomas Cech (1989) — catalytic RNA / ribozymes

•Ahmed Zewail (1999) — picosecond spectroscopy of DNA/RNA torsional dynamics

•Gerhard Ertl (2007) — STM surface topography of Pd single crystals

•Martin Chalfie (2008) — C. elegans neuronal branching

•Martin Karplus (2013) — protein dynamics simulations

•Michael Levitt (2013) — protein normal mode dynamics

•Eric Betzig (2014) — near-field scanning optical microscopy

Physiology or Medicine future laureates cited:

•Eric Kandel (2000) — cellular basis of learning and memory

•John Sulston (2002) — C. elegans neurogenesis

Hameroff also explicitly discusses the 1986 Physics Nobel (Binnig/Rohrer for STM) in the book — and a 15th future laureate, J. Georg Bednorz, would win the Physics Nobel later that very year (1987, high-Tc superconductivity), with his silver-films STM paper already cited in the nanotechnology chapter.

https://t.co/Rzp7K3o6px

[JJ @JosephJacks_]

@hthieblot Yes.

[JJ @JosephJacks_]

@Carles_Reina Very nice.

[MTS @MTSlive]

SITUATION EXPLAINED: For the first time, AI-designed viruses were given to a human patient to fight a drug-resistant infection.

• The viruses are bacteriophages, which only infect bacteria, designed by Omnii-1, a genome language model from Radical Numerics, a startup founded by members of the Arc Institute's Evo team
• The patient's E. coli infection resisted antibiotics and every available phage
• Omnii-1 redesigned the "legs" phages use to grab bacteria, and a cocktail of the new variants wiped out the patient's bacteria in a lab dish
• The cocktail then went to the patient under compassionate use, but the outcome hasn't been shared, citing privacy
• Antibiotic resistance could cause nearly 40M deaths by 2050, and finding the right phage by hand can take months

@theojaffee: "A virus is barely alive. You can just think of them as sort of tiny self-replicators. It literally repurposes the internal machinery of the bacterial cell to make more of itself, and it manufactures so many viruses, the cell will burst, which kills the bacteria."

[Stuart Hameroff @StuartHameroff]

Brain ultrasound to Globus Pallidus relieves delusions in schizophrenia. They don’t know the mechanism but I’ll bet it’s microtubule resonance. Similar low intensity parameters to what we’ve used.
https://t.co/5W2bLxPJkC

[JJ @JosephJacks_]

@DoggyCapital While this is satire, this is actually, in fact, possible from first principles.

So far, Anthropic does not operate from first principles.

[JJ @JosephJacks_]

@XFreeze @elonmusk Perfect union if it happens …

[JJ @JosephJacks_]

@Alfred_Lin @saranormous @PhilipJohnston +1 to Sarah and Alfred

If decision maker is not directly engaged and driving actions and keen… don’t waste time

[JJ @JosephJacks_]

https://t.co/GGUUIPfMny

[JJ @JosephJacks_]

Sundar .. Californium, Fermium, Berkeleium, Mendelevium, Einsteinium and Nobelium … are not identical. Argon thinks they are. 😬😅❤️

[Sundar Pichai @sundarpichai]

Sound on!

[JJ @JosephJacks_]

Gee.. I wonder what would happen if computers all the sudden got millions of times more efficient ?

[TechCrunch @TechCrunch]

Anthropic is reportedly struggling to secure enough compute from cloud providers that increasingly view it as a competitor, even as its infrastructure spending balloons ahead of a planned November IPO.
https://t.co/RI2jr4VOwP

[JJ @JosephJacks_]

@ramin_m_h @exnx @MichaelPoli6 @Massastrello @athmsx

[JJ @JosephJacks_]

@sundarpichai 😂 🤌🏼

[JJ @JosephJacks_]

@beffjezos @ashebytes 🔥

[Beff (e/acc) @beffjezos]

The most candid and human interview I've done - a convo with @ashebytes

We cover my upbringing, theoretical physics days, journey through quantum, e/acc, founding Extropic, the need for a philophical revolution and Kardashev Research

[JJ @JosephJacks_]

@alexeheath @sundarpichai Sundar!! 🤓

[MTS @MTSlive]

SITUATION DETECTED: Bio startup Radical Numerics has used AI-generated viruses - bacteriophages designed by its multimodal genome model Omnii-1 - to treat an antibiotic-resistant infection in the first clinical use of AI-generated phages on a human patient.

[JJ @JosephJacks_]

@elonmusk Yes.

[JJ @JosephJacks_]

@willieneis @keshigeyan 🔥

[Plane @planepowers]

Assign a work item to Cursor or Claude to code. Review and merge it yourself. Let agents execute and humans decide.

[JJ @JosephJacks_]

Mostly: an Ernst Haeckel plate of alien species. Also a museum drawer of pinned moths, an archaeologist's tray of arrowheads, a set of 18 Rorschach cards, an 18-letter alien alphabet, or a WWII aircraft-spotter chart for a fleet that never existed.

Top row

1A gilded harlequin made of Sierpinski triangles
2A leafy sea dragon, or a moss-eaten gargoyle
3A pink plumb bob hanging from its string
4A family of Christmas trees posing for a photo
5The Eiffel Tower in lace
6A lapis-and-gold pendant, or a squid with its tentacles down

Middle row

1A jade spinning top
2A gold-leaf Gothic altarpiece
3Arrow fletching, or a fishbone
4A manta ray, or a paraglider with its lines converging on the pilot
5A circus big-top dripping jellyfish tentacles
6Sergeant's chevrons on a fir branch
Bottom row
1Shock diamonds in a rocket's exhaust
2A tipi, an A-frame, or a drafting compass
3Wisteria, or an amethyst chandelier
4A frozen waterfall full of ice caves
5Tiered Thai temple roofs, or a squadron of paper planes
6A Zuni turquoise needlepoint earring
More, looser

•Architecture: Hindu temple towers (actually fractal: towers built from smaller towers), Sagrada Família pinnacles, Gothic spires, Art Deco crowns, Borobudur

•Textiles: Shipibo kené designs (said to be songs made visible), Navajo eyedazzler blankets, Huichol beadwork, kilims, Fair Isle knitting charts

•Nature: cone-snail shells (they lay down pigment one row at a time, like a 1D automaton), siphonophores, frost crystals, ferns, pine cones

•Things that cascade from one point: champagne towers, Galton boards, willow fireworks, Pascal's triangle colored mod 2

•Physics: light cones, or tiny universes with the Big Bang at the top and the Big Crunch at the bottom

•Sci-fi: starship silhouettes, delta-wing bombers, 8-bit sprites, glitch art

•Wilder: a choir of robed ghosts, Christmas trees mid-fever-dream, rockets designed by a Byzantine icon painter, heraldry for a kingdom of triangles

What they actually are: 1D cellular automata. Each one grows from a single cell at the top, with time running downward. The rules are symmetric, so the patterns are mirror-symmetric. Each pattern eventually dies out, so every picture is a complete lifetime from birth to death. They look a lot like the evolved "organisms" from Wolfram's minimal model of biological evolution, which is probably why they read as specimens.