Proteo & Bioinfo

The main objective of this journal is to promote and develop the coordination between the sciences for the practice of proteomics “in and with” bioinformatics.

[Proteo & Bioinfo @jpbopenaccess]

changes in #gene #Expression for the model bacterium E. coli happen almost entirely during the #transcription stage while the cells are growing. The #researchers have provided a simple quantitative formula linking regulatory control to #mRNA and #protein levels. #proteomics

[Proteo & Bioinfo @jpbopenaccess]

A research team at the University of Cologne discovered that signal peptidase complex has a hitherto unknown function in another key process in #CellBiology: the quality control of membrane #proteins.
#proteomics #Bioinformatics

[Proteo & Bioinfo @jpbopenaccess]

#Quantitative #top-down proteomics unveiled differentially expressed #proteoforms between the two #cell lines," the researchers reported, "and the corresponding #genes had diversified #functions and were closely related to #cancer."
#proteomics #Bioinformatics #submit

[Proteo & Bioinfo @jpbopenaccess]

Latest study describes the development and validation of siRNAs exhibiting high antiviral activity against SARS-CoV-2. In particular, multiple of 3-siRNA combinations developed in the study are sufficient to recognize all correctly sequenced SARS-CoV-2 sequences available to date

[Proteo & Bioinfo @jpbopenaccess]

pathological impacts of the structural components of severe acute #respiratory syndrome #coronavirus -2 (SARS-CoV-2) on human periodontal cells and tissue to understand the association between coronavirus disease 2019 (COVID-19) and deteriorating #oral #health.
#submit #research

[Proteo & Bioinfo @jpbopenaccess]

Rise and waning of #SARSCoV2 #antibody responses induced by #mRNA #vaccines #Booster in a healthcare worker #population .
#proteomics #research #submit #Bioinformatics #pandemic #proteins

[Proteo & Bioinfo @jpbopenaccess]

A Dana-Farber-led team used #spatial single-cell #transcriptomics to visualize diffuse midline #glioma #Cancer #cell #structures across different #age groups and locations.
#submit #research #paper #proteomics #Bioinformatics #OpenAccess #peerreview

[Proteo & Bioinfo @jpbopenaccess]

Organelles called peroxisomes are vital for human #health because they house important metabolic enzymes. However, how #enzymes are imported into peroxisomes has been mysterious, particularly because folded #proteins and even protein oligomers can cross the peroxisomal membrane

[Proteo & Bioinfo @jpbopenaccess]

Recently researchers used #metabolomics to discover potential #biomarkers of #hepatocellularcarcinoma (HCC). They investigated the metabolomes of #tumor and non-tumor tissue in 20 patients with primary HCC using capillary #electrophoresis-time-of-flight #massspectrometry.

[Proteo & Bioinfo @jpbopenaccess]

#genomics England test whether #sequencing #babies genomes at #birth could help speed up the #diagnosis of #rare #Genetics #diseases , and ensure #faster access to #treatment .
#submit #Researchpaper #proteomics #Bioinformatics #Genesis #journal #Peerreview

[Proteo & Bioinfo @jpbopenaccess]

#DNA Changes that Don’t Change protein ,Still Affect Function in Time
#Genetics changes that alter the speed of #protein synthesis without altering the sequence of #aminoacids in the protein, can fold the protein in abnormal ways to change its activity, the research team said

[Proteo & Bioinfo @jpbopenaccess]

One important facilitator of #precisionmedicine is #proteomics. Proteomics can complement #Genomics information to enable and improve the #Discovery of #biomarkers that hold the key to understanding how #diseases develop.

[Proteo & Bioinfo @jpbopenaccess]

In a recent study, #researchers used #proteomics #analysis to identify novel #immune #cell #phenotypes associated with severe #coronavirus #disease #2019 (COVID-19). Additionally, they compiled cumulative immune cell #dysregulation in #progressive disease.
#submit #research

[Proteo & Bioinfo @jpbopenaccess]

#researchers from Insilico Medicine, University of Copenhagen, and University of Chicago unravel #molecular secrets hidden in #premature #aging #diseases and #Cancer using #ArtificialIntelligence #proteomics #Bioinformatics #submit #researchpaper #newwork

[Proteo & Bioinfo @jpbopenaccess]

Within the #agricultural #INDUSTRY , #Bioinformatics has been used to #expand the current understanding of various #plants #functions, protect plants against #harmful #stressors, and improve plant #quality for #human #consumption.
#researchpaper #plantgenetics #submit #crops

[Proteo & Bioinfo @jpbopenaccess]

#Individuals with #Schizophrenia had a significantly higher rate of rare #tandemrepeats in their #genomes, 7% more than individuals without schizophrenia. Tandem repeats were not randomly located throughout the genome; they were primarily found in genes crucial to schizophrenia.

[Proteo & Bioinfo @jpbopenaccess]

#Asthma #Exacerbations prevention is pivotal in #clinical practice, risk classification of patients is a daunting task due to the intrinsically #heterogeneous biological mechanisms of AEs. Nevertheless, #omics studies have uncovered AE-associated biological processes and genes.

[Proteo & Bioinfo @jpbopenaccess]

Scientists have used a #proteomics approach to identify a three-#protein signature in the #Blood that can improve detection of isolated impaired #glucose tolerance, a form of #prediabetes
#bioinformatics #submit #researchers #Paper #Labouratory #Genomics #diabetes #insulin

[Proteo & Bioinfo @jpbopenaccess]

Multiomics profiling and hypertension!!
Hypertension, characterised by a constant high blood pressure is major cause of death in adults. Innovations high-throughput technologies has enabled exploration of the whole genome revealing dysregulated genes linked to hypertension.

[Proteo & Bioinfo @jpbopenaccess]

In high-throughput proteomic projects, routine protein identification is typically accomplished using MALDI-TOF MS peptide-mass fingerprinting, which involves the enzymatic digestion of proteins, yielding a unique subset of peptide masses.
For more info @ https://t.co/ncgI7oGBj0