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[Neuroscience News @NeuroscienceNew]

Inflammation Tied to Motivation Loss in Schizophrenia

A new study has identified a biological link between inflammation and motivational deficits in people with schizophrenia, offering hope for treating symptoms that current medications often fail to address.

Researchers found that higher levels of C-reactive protein (CRP), a marker of inflammation, were associated with reduced activity in brain regions tied to reward and motivation.

These brain changes were linked specifically to negative symptoms like lack of initiative or goal-directed behavior—not to hallucinations, delusions, or depression.

The study focused on brain circuits involving the ventral striatum and ventromedial prefrontal cortex, which are sensitive to inflammation.

This research supports a precision medicine approach, suggesting that anti-inflammatory treatments may benefit only those with elevated inflammation and motivational impairments.

A new clinical trial is underway to test infliximab, an anti-inflammatory drug, in this targeted patient group.

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Repo

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