Phil Becker

Biochemist working on therapeutic oligonucleotides. Currently doing a postdoctoral fellowship at UMass Medical School

[Phil Becker @JPhilBecker]

Hot off the press:

Excited to share a fantastic review from our very own @WellerCelly, just published in CHIMIA!

"Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins"

Check out the full review here: https://t.co/B2gXp1syqV

[Phil Becker @JPhilBecker]

This one goes out to all the oligo chemists - we made the chemdraw feature public and added a few new functions here and there. Check it out!

[Oligowizard @Oligowizard]

The chemical structure drawing tool is now publicly available - no sign-up required! Check it out at:
https://t.co/KrYawqKBvm

#oligotherapeutics #RNA #oligos

[Phil Becker @JPhilBecker]

At the 2024 OTS meeting in Montreal!

[Oligowizard @Oligowizard]

Version 4.0 is live! Fresh design, more customisation, professional HPLC traces, batch processing and generating ChemDraw structures from sequences
All now https://t.co/vuBPTROFr3 !

[Phil Becker @JPhilBecker]

@CVRinfo @CVRHutchinson Wow that's great - congratulations, Ed!

[Phil Becker @JPhilBecker]

@JorgStulke @VAAM_Microbes Looks great! Say hi to @RNATobi from me!

[Phil Becker @JPhilBecker]

@BriggsGroup @jpeukes @bio_physics Looks great!

[Phil Becker @JPhilBecker]

@AmandaZihanZhu @nicole_robb1 @CVRHutchinson Amanda, congratulations on your successful DPhil!
Well done!! 🥳

[Swiss RNA Therapeutics Summit @RNATX_CH]

Register Now & Submit Abstracts for the 2nd Swiss RNA Therapeutics Summit, January 25, 2024, @unibern.
https://t.co/sGthKcwwh0
@Roche @kanton_bern Economic Development Agency
@C_Leumann @PNioi @MartinJinek @snsf_ch @ETH_en

[Phil Becker @JPhilBecker]

The Jonathan Hall lab @ETH_DCHAB @ETH_en had a fantastic time at the #oligomeeting #ots23 by the @OTSociety !! Four days of fantastic talks and stimulating exchanges! Huge congrats to Mathilde Vincent @mathilde9v and Štefan Moravčík for winning the poster prizes!

[Phil Becker @JPhilBecker]

Lots of phenomenal exchanges and ideas at #oligomeeting #ots23 hosted by @OTSociety ! Thanks to everyone for the great discussions; and thanks to the OTS for the travel grant!!

[Phil Becker @JPhilBecker]

Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics
Here’s a teaser:
🧵

[AnnemiekeAartsma-Rus @oligogirl]

LAA discussion went to controls ⁦@OTSociety⁩ #ots23 As ⁦@F_ANAtico⁩ mentioned there is a great review about this inspired by work from both winners Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs - PubMed https://t.co/OcQi7CHpqt

[Phil Becker @JPhilBecker]

Check out P149 by @EvaMariaManz2 to learn about base editing to treat the EPP SNP, P167 by Štefan Moravčík on selective/chemical RNA methylation, P235 by @mathilde9v on the influence of PS linkages on oligo-protein interactions, and P239 by @WellerCelly on RNA PROTACS!

[Phil Becker @JPhilBecker]

Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics
Here’s a teaser:
🧵

[Phil Becker @JPhilBecker]

But can we reproduce this splicing correction in our new vivo model? Come and find out at P23 tonight!

Big thanks to @NCCR_RNADisease and @snsf_ch for funding the project! I’m also very grateful to @SwissChemistry and @SCNATChemistry for the chemistry travel award!!

[Alyssa Hill, PhD @alyssa_hill]

In new work resulting from a collab. with @Roche, we show peptide conjugates of an #ASO 🧬 are inactive in cells due to endosomal entrapment. Getting #oligos into cells is only half the battle - the next question is how do we get them out of endosomes? ⭐️ https://t.co/F8IBPhlTQB

[Oligowizard @Oligowizard]

Great talk at @ETH by @DrMikeBooth on #oligonucleotides and how they can be turned into light-sensitive switches!

[Phil Becker @JPhilBecker]

@baym Hope you read the paper nonetheless - it’s excellent work!