Hot off the press:
Excited to share a fantastic review from our very own @WellerCelly, just published in CHIMIA!
"Oligonucleotide-based PROTACs to Degrade RNA- and DNA-Binding Proteins"
Check out the full review here: https://t.co/B2gXp1syqV
The chemical structure drawing tool is now publicly available - no sign-up required! Check it out at:
https://t.co/KrYawqKBvm
#oligotherapeutics#RNA#oligos
Version 4.0 is live! Fresh design, more customisation, professional HPLC traces, batch processing and generating ChemDraw structures from sequences
All now https://t.co/vuBPTROFr3 !
Register Now & Submit Abstracts for the 2nd Swiss RNA Therapeutics Summit, January 25, 2024, @unibern.
https://t.co/sGthKcwwh0
@Roche@kanton_bern Economic Development Agency
@C_Leumann @PNioi @MartinJinek @snsf_ch@ETH_en
The Jonathan Hall lab @ETH_DCHAB@ETH_en had a fantastic time at the #oligomeeting#ots23 by the @OTSociety !! Four days of fantastic talks and stimulating exchanges! Huge congrats to Mathilde Vincent @mathilde9v and Štefan Moravčík for winning the poster prizes!
Lots of phenomenal exchanges and ideas at #oligomeeting#ots23 hosted by @OTSociety ! Thanks to everyone for the great discussions; and thanks to the OTS for the travel grant!!
LAA discussion went to controls @OTSociety #ots23 As @F_ANAtico mentioned there is a great review about this inspired by work from both winners Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs - PubMed https://t.co/OcQi7CHpqt
Check out P149 by @EvaMariaManz2 to learn about base editing to treat the EPP SNP, P167 by Štefan Moravčík on selective/chemical RNA methylation, P235 by @mathilde9v on the influence of PS linkages on oligo-protein interactions, and P239 by @WellerCelly on RNA PROTACS!
But can we reproduce this splicing correction in our new vivo model? Come and find out at P23 tonight!
Big thanks to @NCCR_RNADisease and @snsf_ch for funding the project! I’m also very grateful to @SwissChemistry and @SCNATChemistry for the chemistry travel award!!
In new work resulting from a collab. with @Roche, we show peptide conjugates of an #ASO 🧬 are inactive in cells due to endosomal entrapment. Getting #oligos into cells is only half the battle - the next question is how do we get them out of endosomes? ⭐️ https://t.co/F8IBPhlTQB