Oligowizard

Supporting Preclinical Development of Nucleic Acid Therapeutics 🧬🧙🏻‍♂️

[Oligowizard @Oligowizard]

Version 4.0 is live! Fresh design, more customisation, professional HPLC traces, batch processing and generating ChemDraw structures from sequences
All now https://t.co/vuBPTROFr3 !

[Oligowizard @Oligowizard]

Here we go! #OTS2025

[Oligowizard @Oligowizard]

Our database on approved nucleic acid therapeutics is online:

https://t.co/yqvENT1PG9

Let us know what you think, and do get in touch if you’d like to contribute!

[Oligowizard @Oligowizard]

The issue is finally fixed! Thank you for your patience!

[Oligowizard @Oligowizard]

We are currently experiencing problems with the SSL certificate for https://t.co/vuBPTROFr3.
You can still reach the site via http rather than https.
We are looking into fixing this issue as quickly as possible - apologies for the inconvenience!

[Oligowizard @Oligowizard]

The chemical structure drawing tool is now publicly available - no sign-up required! Check it out at:
https://t.co/KrYawqKBvm

#oligotherapeutics #RNA #oligos

[Oligowizard @Oligowizard]

New FDA GUIDANCE on 'Nonclinical Safety Assessment of Oligonucleotide-Based Therapeutics':

https://t.co/6TJVHci7Xt

[Ronald Buijsen @BuijsenRonald]

Time for the #OTS24 awards session!

Congrats @OTSociety poster winners!

[Oligowizard @Oligowizard]

Prof Steve Dowdy wrapping up the delivery session. How do we tackle the 800 pound gorilla that is endosomal escape?
#OTS #OTS2024 #oligomeeting

[Oligowizard @Oligowizard]

@DrMikeBooth They really are!!

[Oligowizard @Oligowizard]

Excited for the next gen session hosted by trainee representatives Eva-Maria Manz of ETH Zürich and Jathavan Asohan of McGill #OTS24 #oligomeeting #OTS

[Oligowizard @Oligowizard]

Here we go! #OTS24 #oligomeeting #oligotherapeutics

[Oligowizard @Oligowizard]

@CMordstein Christine, thanks for the complement! OW is run by @JPhilBecker. The project is still very much under active development - there are new features every few months!

[Oligonucleotide Therapeutics Society @OTSociety]

THE DEADLINE FOR MENTORSHIP APPLICATIONS IS TODAY!

Mentor-mentee matches are completed by mid-August.

Don't miss this chance! Apply today!
https://t.co/bkmo2uQhSG

#OTS #oligotherapeutics #oligonucleotides #science #research #mentorshipprogram #oligoresearchers #sciencecareer

[Oligowizard @Oligowizard]

Great paper!
But what happened to the pyrimidine N1 Nitrogen? 😉

[Science Magazine @ScienceMagazine]

Oligonucleotide therapeutics are emerging as a powerful platform for modulating gene expression across a range of diseases and applications.

A new #ScienceReview takes a look at recent advances that aim to transform oligonucleotide manufacturing. https://t.co/E1A8cMuo6S

[Oligowizard @Oligowizard]

@jptosar We think that gymmosis is largely driven by increased protein binding of oligos containing phosphothioates. Modified oligos such as nusinersen happily enter the cell but struggle to escape the endosomes. Here increased nuclease stability might allow them to form a leaky depot

[Oligowizard @Oligowizard]

We’re celebrating our first mention in the scientific literature 🥳

Work by @alyssa_hill et al. in @ACS_Omega used oligowizard to calculate the properties of their (maleimide-modified) oligos!

Check out their paper below:

https://t.co/cdtP9a6JWD

[Phil Becker @JPhilBecker]

Very excited to present our work on oligo-conjugates towards the treatment of EPP @OTSociety #ots #ots23 #oligomeeting #oligotherapeutics
Here’s a teaser:
🧵

[Oligowizard @Oligowizard]

Let’s go!
#OTS #OTS23 #oligomeeting

[Oligowizard @Oligowizard]

Great talk at @ETH by @DrMikeBooth on #oligonucleotides and how they can be turned into light-sensitive switches!