Jack Killinger

Bioengineering PhD student @SMSheaLab @PittTTMRC | @PittBioE @PittSurgery

[Ming "Tommy" Tang @tangming2005]

The Hidden Chaos Behind Beautiful Bioinformatics Figures
1/15 You only see the final beautiful figure in that bioinformatics paper. But behind every clean heatmap lies a storm of trials, errors, and late-night debugging sessions.

[Ming "Tommy" Tang @tangming2005]

3/15 RNA-seq analysis. PI: "Just run differential expression and get me the pathways." Reality: 50 emails debating fold-change cutoffs, p-value adjustments, and whether DESeq2 or edgeR is better.

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

In a secondary analysis of a trial of TBI patients on antiplatelet therapies receiving platelet transfusions, VerifyNow and TEG-PM do not detect differences to platelet function between patients receiving cold-stored and room temperature platelet units.

@jrkillinger99 @macky_neal @PittSurgery @PittTTMRC @PittNeurosurg

https://t.co/ofK0tknVER

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

In a secondary analysis of a trial of TBI patients on antiplatelet therapies receiving platelet transfusions, VerifyNow and TEG-PM do not detect differences to platelet function between patients receiving cold-stored and room temperature platelet units.

@jrkillinger99 @macky_neal @PittSurgery @PittTTMRC @PittNeurosurg

https://t.co/ofK0tknVER

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

In a secondary analysis of a trial of TBI patients on antiplatelet therapies receiving platelet transfusions, VerifyNow and TEG-PM do not detect differences to platelet function between patients receiving cold-stored and room temperature platelet units.

@jrkillinger99 @macky_neal @PittSurgery @PittTTMRC @PittNeurosurg

https://t.co/ofK0tknVER

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy https://t.co/xJABFTOdrH

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

Watch an overview of "Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy" presented by Dr. Neal!🎬

https://t.co/vDVKL81soX

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

❇️Best of Trauma❇️

Read the article "Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy"

https://t.co/oM8MfokAM9

[Journal of Trauma and Acute Care Surgery @JTraumAcuteSurg]

In an RCT of TBI patients on antiplatelet therapy, higher absolute TEG-PM values predicted better clinical outcomes. VerifyNow ASA showed improvement after transfusion. Transfusion-induced assay changes were not associated with clinical outcomes.

https://t.co/oM8MfokAM9

[AABB @AABB]

A new article in The @NewYorker highlights the @NHSBT-led RESTORE trial, the first in the world to transfuse lab-grown red blood cells into people. https://t.co/ItaLLv4kge

[Susan Shea @SMSheaLab]

VERY proud of my first year @PittBioE grad student @jrkillinger99 for giving a great talk about our recent findings regarding the circulating #lipidome in stored #platelets at #AABB24 ! @PittTTMRC @PittSurgery

[Susan Shea @SMSheaLab]

Dr. Khandaker from my lab gave an update on the CHIPSiv study comparing room temp vs cold stored #platelets - looking pretty good in vitro out to 21 days across multiple platforms! @PittTTMRC @PittSurgery

[Luke Schaffer (he/him) @Lukas_Schaffe]

So so so happy to share that my first, first-author paper from my time at @NIMHgov is now available online at Journal of Neurodevelopmental Disorders!

https://t.co/Mr9ggo9Uw1

See below for a 🧵of key findings... 1/

[Susan Shea @SMSheaLab]

It’s orientation day for our incoming @PittBioE #PhDstudents! @jrkillinger99 and @rahn_kate rocking the blue and gold kicking off a great start to their first semester as grad students 🤩

@PittTTMRC

[Luke Schaffer (he/him) @Lukas_Schaffe]

ASD and ADHD share considerable genetic overlap. Here, we disentangle this shared genetic basis and investigate the unique genetic pathways for ASD persisting independently of ADHD. We find genetic links with psych d/o's, cognition, transcriptome, and more! More deets below! 🧬🧠

[IBG @IBG_CUBoulder]

🚨 New preprint from IBG graduate student @Lukas_Schaffe that examines the genetic signal in autism spectrum disorder (ASD) that is unique of ADHD. Findings reveal clinical correlates, genes, and biological pathways unique to ASD. https://t.co/vnMOTjImtO

[Susan Shea @SMSheaLab]

New in print! We found reduced platelet content in #microfluidic clots in #trauma patient samples relative to healthy controls. @kim_thomas_phd @PhilSpinellaMD @macky_neal @RonitKar_ @rahn_kate @PittTTMRC @PittSurgery

Check it out at @PLOSONE 👇🏻

https://t.co/o9JmqWTK0S

[Luke Schaffer (he/him) @Lukas_Schaffe]

so grateful to present my work on the unique genetics of autism at my first ever #BGA2024 ! even better that I got to do so alongside some fantastic early career researchers in neurodevelopmental genetics :)

[IBG @IBG_CUBoulder]

Congratulations to IBG graduate student @Lukas_Schaffe for receiving the award for best oral presentation at the 2024 BGA Meeting in London! 🏆🥳🧬

[Jack Killinger @jrkillinger99]

Honored to have had the opportunity to present @ISTH in #Bangkok this year and grateful for those (@macky_neal @SMSheaLab @PittTTMRC) who made it possible. Looking forward to many more ISTHs to come. (Post delayed due to post-conference vacation fun in #Phuket with @rahn_kate)