What are tertiary lymphoid structures (TLSs)? We found evidence of adaptive immunity in #ovariancancer. Check out our #bioRxiv preprint https://t.co/LrewuVpFZa Great collaboration with @jsarkkine@lettipitko
Old friends reunited in CML! 🤝 Our study of a clinical trial shows that the addition of IFN-α curtails the immunological effects of dasatinib in CML, out now in @jclinicalinvest. More about the study and immunology in CML in a slideset below: 🧵 https://t.co/Kr60okbLdp
This work would not have been possible without @QuPath and @FinbbSuomi sample collections. Funding from @EJPRareDiseases made everything possible. Thank you all co-authors and of course @jsarkkine who did all the work! Full article here: https://t.co/oHigf5bY5e
that are central to pathology, are produced in the thymus. MG is an unique opportunity to study autoantibody production in situ! This information could help understand autoantibody production in other diseases as well.
This is our first report from the @taridconsortium - stay tuned, we have much more exciting research into MG and extopic germinal centers in progress. One might wonder why to study a rare autoimmune disease when there are more common ones. In MG we know that the autoantibodies
For me as thymus-enthusiast the most interesting finding was that women woth MG (mostly EOMG) had larger area of Hassall’s corpuscles, those small clusters of epithelial cells in the thymus that nobody really knows what their function is 🧐.
centers are common on EOMG thymi but could also show that the eGC number directly correlates with the patient’s outcome after thymectomy. eGCs were rare in patients over 45 yrs. Pathology of the thymus is thus clearly different in early and late onset diseases.
Myasthenia gravis is a autoimmune disease where autoantibodies targeted againts nerve-muscle junction cause severe muscle weakness. Thymic pathology is often present and esp in early-onset MG, thymectomy alleviates symptoms. We confirmed earlier findings that extopic germinal
New results from our group 🌟, project lead by @jsarkkine and now published in @ModernPathology. We studied thymus histology @FinbbSuomi in rare autoimmune disease myasthenia gravis with generous support from @EJPRareDiseases @taridconsortium https://t.co/oHigf5bY5e. Small🧵
Vaikea ymmärtää Etelä-Suomen AVI:n päätöstä liikunta- ja harrastustilojen rajoitusten jatkamisesta. Sairaalakuormitus on ollut stabiili yli viikon. Nämä rajoitukset aiheuttavat merkittävää haittaa ihmisten hyvinvoinnille eikä niitä voi jatkaa vaan varmuuden vuoksi.
Fantasiassani olen päässyt päättämään Suomen koronalinjauksista. Pidän täällä Twitterissä nyt tiedotustilaisuuden uusista linjauksista, pitäkää hatuistanne kiinni! Koska en poliitikko en oikeasti tiedä miten nämä lainopillisesti menevät mutta sitä vartenhan on virkamiehet 💪🏻