🌊 Developmental biologists say gastrulation is the most important moment of your life… and this sea urchin is making sure it looks fabulous for the occasion 💅
🔴 Laminin 🟢 Skeletal cells 🔵 Membranes 📸 Image from David McClay #FluorescenceFriday#DevBio
Really excited to present the results of a fantastic collaboration with Jesse Veenvliet (@jvveenvliet) @mpicbg@PoLDresden 🤩
We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species
➡️https://t.co/slJgS87a1k
Ascidians (Ciona intestinalis)🪸Our distant chordate cousins! 🌊 Simple sea squirts that reveal how vertebrate body plans evolved 🧬 A key model for notochord formation, neural induction, and cell lineage mapping 📸 Video by MBL Embryology 2019 #ModelMonday#DevBio#EvoDevo
“It turns out it was not a grizzly bear and she said, “You won the Nobel Prize!”
Yesterday Fred Ramsdell was awarded the Nobel Prize in Physiology or Medicine but, at the time, he and his wife were completely off-grid camping in Yellowstone National Park.
Unsurprisingly when they finally returned to an area with phone service the messages poured in. Ramsdell talked to us on his way home from Yellowstone, sharing how a day that began with wildlife spotting can end up with the Nobel Prize.
#NobelPrize
“The dog is a bit confused about what’s going on.”
New medicine laureate Mary Brunkow was caught off guard this morning when she discovered she had been awarded the 2025 Nobel Prize in Physiology or Medicine.
When we talked to her after she heard the news her surprise was palpable – she explained the “molecular slog” involved in her work and how research “takes a bunch of different brains working together.”
Congrats to Mary Brunkow *91 on receiving the the 2025 Nobel Prize in Physiology or Medicine for her work on “the discovery of how the immune system is kept in check.”
“I believe this will encourage immunologists and physicians to apply T regulatory cells to treat various immunological diseases.”
This year’s Nobel Prize laureate, Shimon Sakaguchi, discovered a new class of T cells that protect the body from autoimmune diseases.
Just after the prize announcement we spoke to him about the fundamental research question that kept him dedicated to the field long after many others gave up.
Listen to our interview with the happy and surprised laureate:
#NobelPrize
BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
Between 2 and 3 months, a baby grows from the size of a blueberry to a fig, developing a beating heart, moving limbs, and a rapidly growing brain. 😲
https://t.co/X1UlK1mKbQ
🧠✨ E14 mouse embryo lighting up with neural progenitors!
Nestin (⚪️), p73 (🟢), and Tbr2 (🔴) mark distinct progenitor populations shaping the nervous system.
@VishalLolam is investigating how their balance is disrupted in neurodevelopmental disorders.
#FluorescenceFriday
This year’s #NobelPrize laureates in chemistry have revealed proteins’ secrets through computing and artificial intelligence.
Chemists have long dreamed of fully understanding and mastering the chemical tools of life – proteins. This dream is now within reach. 2024 chemistry laureates Demis Hassabis and John M. Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. This year’s chemistry laureate David Baker has learned how to master life’s building blocks and create entirely new proteins. The potential of their discoveries is enormous.
The ability to create proteins that are loaded with new functions is just as astounding. This can lead to new nanomaterials, targeted pharmaceuticals, more rapid development of vaccines, minimal sensors and a greener chemical industry – to name just a few applications that are for the greatest benefit of humankind.
“It’s absolutely extraordinary.”
John Jumper just heard the news of his 2024 #NobelPrize in Chemistry when we spoke to him. His plan was to sleep in today - it didn’t quite work out.
He talks about AI's role in science – and being the youngest chemistry laureate in over 70 years.