JustSomeNp

Girl dad. Lego Batman voice dbl. Boarder. Lifter. Interventional pain NP/Hx:Trauma/ER/ICU/CCT/FM. Mimbres-born, Appalachia-forged, Chesapeake-finished. JKL🤙🏼

[JustSomeNp @justsome_np]

@CantEverDie Yes, because your mindset of dying on the 20 side of every 80/20 hill is the REAL winner’s mindset right?

[JustSomeNp @justsome_np]

@AlexNoonan6 Mating I presume

[JustSomeNp @justsome_np]

IYKYK

[Charco @charcoded]

funny how any dumbbells above 60lbs always get put back in the correct spot

[JustSomeNp @justsome_np]

@JulieChangRE Bernal heights in SF — crime don’t climb

[JustSomeNp @justsome_np]

@emnode @BulwarkOnline They made her paddle a canoe through the Dells

[Foster @foster_type]

It's nothing new but it's the undefeatable proposition. There's no credible counterargument and the most disturbing thing is how many people understand that it's true while also pushing for Israeli disarmament.

[JustSomeNp @justsome_np]

These are crazy numbers yall

[Dr Danish @operationdanish]

🤯 JUST IN: INCREDIBLE PHASE 3 DATA ON RETATRUTIDE PRESENTED AT ADA

At ADA this weekend, Eli Lilly ($LLY ) presented new Phase 3 data from TRIUMPH-1 and TRANSCEND-T2D-1. BLUF: 28% (70 pounds) weight loss. Unreal.

In TRIUMPH-1, participants receiving 12 mg of retatrutide lost an average of 70.3 pounds (28.3%) over 80 weeks. Nearly half achieved at least 30% weight loss, and 65.3% were no longer classified as obese (BMI <30) by the end of the study. Among participants who started with BMI ≥35 and continued treatment to 104 weeks, average weight loss reached 85 pounds (30.3%), with no evidence that weight loss had fully plateaued.

What stood out more was the breadth of effect across obesity-related conditions:

Knee osteoarthritis pain improved by 73.1%
Obstructive sleep apnea severity improved by 60.6%
Triglycerides fell by as much as 41.0%
Non-HDL cholesterol declined by 24.2%
Systolic blood pressure dropped by 12.3 mmHg
Waist circumference decreased by 9.5 inches

Meanwhile, in TRANSCEND-T2D-1, retatrutide produced A1C reductions of up to 2.0% from a baseline of 7.9%.

90% of patients achieved A1C <7%
85% achieved A1C ≤6.5%
46% reached A1C <5.7%, which is below the threshold used to define prediabetes
Patients lost 36.6 pounds (16.8%) at 40 weeks, and weight loss was still ongoing at study end.

Obesity medicine is increasingly becoming outcomes medicine.

Historically, we have evaluated obesity drugs primarily on percent weight loss... but payers ultimately care about sleep apnea, osteoarthritis, diabetes, cardiovascular risk, and healthcare costs.

The significance of TRIUMPH-1 and TRANSCEND-T2D-1 is that Lilly is beginning to show a coherent story across those endpoints, not just body weight. I expect this to expand coverage dramatically.

Eli Lilly is the Nvidia of healthcare.

[Eric Boehm @EricBoehm87]

The impulse to demand that executive power get used to solve every single perceived problem is the number one thing eroding American democracy

[JustSomeNp @justsome_np]

@mnolangray @realTWB52 @judgeglock Can confirm— most combat vets I know are at 100%, a lot of it is for psych injury, when they get out ppl basically tell them to go in an ask for 100% it’s almost hard to avoid it if you were forward deployed

[JustSomeNp @justsome_np]

Almost feel bad for the podbros, something about mamdani and Platner taking over the party with ideas that are totally contrary to Obama’s has made all their brains turn to mush, sad to see really

[Tommy Vietor @TVietor08]

Pritzer should strip the team from the McCaskey family and give every Chicago resident a stake.

[Ian Miller @ianmSC]

It really is remarkable that the three largest cities in the most powerful country on earth are led by some of the most incompetent people we’ve ever seen

[JustSomeNp @justsome_np]

Generational posting talent right here; you really can’t teach this.

[Hunter Biden @HunterBiden]

I see your profile picture. That’s Johnny Cash. My hero too. Arrested seven times. Smuggled 668 amphetamines across the Mexican border in 1965. Took every drug there was and drank like I did. Cheated on his first wife. Slept with more woman than I ever did. Hit bottom in a cave in Tennessee in 1968 trying to crawl off and die. And then he got up. He got clean. He spent the rest of his life singing for prisoners and addicts and the people the country threw away because he knew he was one of them.

That was the whole point of the Man in Black. He wore it for the poor and the beaten down. He wore it for the prisoner who has long paid for his crime. He wore it for the ones who never heard a word of Jesus. He wore it for the addicted and the dying. He wore it as a standing witness that no one is past saving.

You picked his picture. You did not pick his message. Try listening to the words.

[JustSomeNp @justsome_np]

@funnysseur @mephistophalic True lol

[JustSomeNp @justsome_np]

#BelieveAllWomen

*unless doing so might prevent your new favorite champagne socialist from becoming a senator… in that case you must try to smear and defame her 🙄

Lotta progressively really showing their true colors on this one

[Michael Tracey @mtracey]

Hilarious that every GOP operative in DC who knows this woman is suddenly rushing to valorize her dirty laundry sob story from 12 years ago, #MeToo-style. No doubt the "kidnapping" and "assault" were so heinous that she only thought to say something right before the Maine primary

[JustSomeNp @justsome_np]

@dilanesper It was frustrating watching MAGA try to defend Trump by poking holes around the edges of major allegations of wrongdoing, when the totality of the evidence clearly suggests that he is an absolutely heinous, evil human being.

It is just as frustrating watching liberals do it here

[JustSomeNp @justsome_np]

@MurrayHillGuy1 If you’re running switch the side of the road.

Consider PRP or prolotherapy

[JustSomeNp @justsome_np]

Probably shouldn’t get too worked up about it considering there is zero chance that a civil settlement between a unitary executive and himself that immunizes him and his family against all past and future consequences for tax crimes is ever gonna hold up in court.

[Acyn @Acyn]

DeLauro: The blanket immunity is not something you’re going to rescind?

Blanche: It’s not blanket immunity.

DeLauro: *reads the order*

[JustSomeNp @justsome_np]

@facetedcarapace @missmayn No one told me I was supposed to stop doing this at some age?

[JustSomeNp @justsome_np]

@MattBruenig @AliceFromQueens Nurses are martial-adjacent??

[JustSomeNp @justsome_np]

@BrentAWilliams2 It without question is ime. My all time favorite drug to de-prescribe for my elderly chronic pain patients, can see the lights come back on after years on 2400-3200/day