Moreover, LAVI actually met statistical significance over the longer term, and both structure and function improved, consistent with the FOREST trial results. For the time being, there is no drug that can catch up in oHCM/nHCM.
#CYTK
Three deaths occurred in the placebo group, and all cases of SHF occurred during the initial dose ‘uptitration’ phase, with 21 out of 27 resolved by diuretics. Raising safety concerns simply because the number of SHF cases increased shows a lack of proper investigation.