Kristian RJ

MD, researching #PrecisionMedicine in #psychiatry & novel treatments for mood disorders at @CopenhagenNeuro. Alumni of @UniofOxford @Caltech and @uni_copenhagen

[Kristian RJ @K_RJensen]

By multi-model, we mean EEG, MRI, fMRI, and PET; by deep, we mean add psychometrics, cognition, genetics, blood samples, health care records, and the Danish registries... 🎯
We have great minds & diverse methods @CopenhagenNeuro to study #MDD heterogeneity and improve treatment.

[BrainDrugsDepression @BrainDrugsMDD]

The protocol for our multi-model neuroimaging work on:
Deep phenotyping towards precision #psychiatry of first-episode #depression — the BrainDrugs-Depression cohort
at @CopenhagenNeuro is now online.

https://t.co/HfYO7vZh1Q

[Drummond E-Wen McCulloch @D_E_McCulloch]

New data, new findings, new preprint! 🧵

Here are the results from the first psychedelic simultaneous PET-MRI study mapping LSD's receptor binding, blood flow changes, and functional connectivity.

https://t.co/LHo6NSFsAy

[Kristian RJ @K_RJensen]

@AM_Doornweerd Nice study and impressive data size given the Covid-constrains.

[Kristian RJ @K_RJensen]

The paper provides comprehensive age and gender-stratified norms for all scales. 📨Write to me for the paper (it is paywalled, sorry) https://t.co/ouWbyjmAbJ

[Kristian RJ @K_RJensen]

In my new paper in the Nordic Journal of Psychiatry, I provide gender and age-stratified Danish mental health norms for clinical scales: Brief Symptom Inventory (BSI-53, BSI-18), ADHD scales, and SCL-10. https://t.co/ouWbyjmAbJ 👇

[Kristian RJ @K_RJensen]

😷 😟Important notice: Recent Danish SCL-10 norms from 2020 during the COVID lockdown show unusually high distress levels. This data from an abnormal period isn't suitable as a population norm. I recommend using the gender-specific 2000 norms. #COVID19 #Psychiatry

[Kristian RJ @K_RJensen]

💡 Conclusion:
LDAEP is not useful as a biomarker for suicide research or prevention in MDD. We need to look elsewhere for approaches to identifying high-risk individuals.
🔗 https://t.co/RgMPyjq9ih
#Depression #Suicide #Neurobiology #EEG

[Kristian RJ @K_RJensen]

📢 New research alert! Does the EEG biomarker LDAEP link to suicidality in Major Depressive Disorder (MDD)? 🧠 Our meta-analysis and independent cohort study reveal key findings. Dive in! 🧵 #depression
🔗 https://t.co/RgMPyjq9ih
[1/5]

[Kristian RJ @K_RJensen]

For LDAEP, we found:
❌ No association with and past suicide attempts.
❌ No correlation with suicidality.
❌ No association with suicidality during 12 weeks after EEG.
This held true across the meta-analysis, in the independent cohort, and in the updated meta-analysis.
[4/4]

[Kristian RJ @K_RJensen]

Key takeaway: Depression treatment may involve more complex brain changes than previously thought. Our results highlight the need to consider sex differences and challenge simplified growth models of antidepressant action. #Psychiatry

[Kristian RJ @K_RJensen]

New paper: We investigated hippocampus volume changes during SSRI treatment in #depression in humans. Contrary to expectations, the hippocampus didn't enlarge - it actually decreased in volume in patients who responded to treatment. 💊
https://t.co/W1Wp8rKxjb

[Kristian RJ @K_RJensen]

Our findings suggest antidepressants may work through synaptic refinement rather than volume growth. The quality of neural circuits might matter more than size when it comes to treatment response. 🧠

[Kristian RJ @K_RJensen]

@chiccorampazzo @AlyceRaybould @peterampazzo @rosssbarker Interesting paper. So, the top apps in high-income countries are Flo, Clue and Periode Tracker Light.
How common do you estimate "built-in" trackers in other apps (e.g. Fitbit) or mobile phone systems (e.g. iOS 13+ Cycle Tracking in Health app)?

[Kristian RJ @K_RJensen]

@ScholarshipfPhd Yes, please!

[Kristian RJ @K_RJensen]

@EikoFried @WileyGlobal Had a dive into the paper today. Good read.
Enjoyed the journal's article type: "LONG DIDACTIC PAPER"