BrainDrugsDepression

A Precision Medicin Study in MDD 🎯 - The moody brother of @BrainDrugsEpi - Run by @K_RJensen at @copenhagenneuro

[BrainDrugsDepression @BrainDrugsMDD]

The protocol for our multi-model neuroimaging work on:
Deep phenotyping towards precision #psychiatry of first-episode #depression — the BrainDrugs-Depression cohort
at @CopenhagenNeuro is now online.

https://t.co/HfYO7vZh1Q

[Kristian RJ @K_RJensen]

📢 New research alert! Does the EEG biomarker LDAEP link to suicidality in Major Depressive Disorder (MDD)? 🧠 Our meta-analysis and independent cohort study reveal key findings. Dive in! 🧵 #depression
🔗 https://t.co/RgMPyjq9ih
[1/5]

[Kristian RJ @K_RJensen]

💡 Conclusion:
LDAEP is not useful as a biomarker for suicide research or prevention in MDD. We need to look elsewhere for approaches to identifying high-risk individuals.
🔗 https://t.co/RgMPyjq9ih
#Depression #Suicide #Neurobiology #EEG

[Kristian RJ @K_RJensen]

😟😔High neuroticism is a risk factor for #depression. We look at how the personality trait is linked to brain serotonin levels during health and depression. 🧵
With @IpsyNru @CopenhagenNeuro and @vibeke_dam
https://t.co/nnbA0F82Qd #OpenAccess

[Kristian RJ @K_RJensen]

Could sex hormones be used to guide treatment for #depression in men?
🙋‍♂️ New paper with @vibefrokjaer 🚨
Psychoneuroendocrine profiles of unmedicated men with major depressive disorder and associations to treatment effects and sexual side-effects 🧵

[Kristian RJ @K_RJensen]

How do we best select treatment for #depression?🧑‍⚕️
A 2017 paper states, “EEG Abnormalities Are Associated With Poorer Depressive Symptom Outcomes With Escitalopram and Venlafaxine, but Not Sertraline” due to a proposed unique anti-convulsive property of Sertalin.⚠️Let's see!🧵

[BrainDrugsDepression @BrainDrugsMDD]

Our large multi-modal neuroimaging cohort of patients with #depression in Copenhagen is now preregistered online at: https://t.co/QUWAB9x7ED

[Kristian RJ @K_RJensen]

Do SSRIs result in hippocampal growth in humans❓💊🧠
I observe a ⬇️ related to improvement in depression. And smaller is better for memory.
Come by my jam in corner 1 today at 10 am or my poster P0756 at 1 pm to hear more. 💬 #ECNP2022

[BrainDrugsDepression @BrainDrugsMDD]

Campfire talk on precision psychiatry in Bubble 1. Come join that conversation! 🔥
#ECNP2022

[BrainDrugsDepression @BrainDrugsMDD]

Astrid has been an essential help in our work on precision #psychiatry for MDD. Join her at her poster today at 1 pm where she presents beautiful work on MDD, #neuroticism, and the role of the 5-HT4 receptor in a 180 person PET study 🧠⭐️
#ECNP2022

[Kristian RJ @K_RJensen]

Want to talk #depression, #sexdifferences and #Neuroticisme in an n=180 5-HT4 receptor PET study❓
Join my super student Astrid Mikkelsen at poster P.0132 at 1 pm today ⭐️
#ECNP2022 🧠

[BrainDrugsDepression @BrainDrugsMDD]

Our related study @BrainDrugsEpi,which also investigates the link between #epilepsy and #depression, asks if epilepsy is a psychiatric disorder. ❓
Join session S05 at #ECNP2022 for the debate in hall E2 at 10:30.
Moderated by @LarsPinborgEpi 🧠

[BrainDrugsDepression @BrainDrugsMDD]

Our related study @BrainDrugsEpi,which also investigates the link between epilepsy and depression, asks if epilepsy is a psychiatric disorder. ❓
Join session S05 at #ECNP2022 for the debate.

[BrainDrugsEpilepsy @BrainDrugsEpi]

'm happy to be part of the 35th ECNP Congress, 15-18 October! Join my session on ‘ S05 – Is epilepsy a psychiatric disorder? ’ in-person in Vienna or online!
You can find more info and register via https://t.co/ej2k1bWaIY.

#ECNP2022 #ECNPCongress #NeuroscienceApplied

[Merete Nordentoft @m_nordentoft]

Mine gode kolleger fra Aarhus universitet har skrevet denne kommentar: Deling af artikel fra https://t.co/wQV3emoMn7: Især tre myter og misforståelser præger psykiatrien. Her er fakta https://t.co/u7wF7Q0amN via @kristeligt

[BrainDrugsDepression @BrainDrugsMDD]

In the @BrainDrugsMDD study, we work hard to ensure that our sample population is diverse and inclusive to avoid creating inequities in predictive accuracy that perpetuate disadvantages for underrepresented groups.

[Kristian RJ @K_RJensen]

Excellent @BJPsych editorial on the ethical perspective of predictive psychiatry in clinical practice by @nataliemlane & @matthewrbroome
Good pointers for the future!
https://t.co/KPy4jQ6hMZ
#precisionmedicin #mentalhealth

[Kristian RJ @K_RJensen]

A 25-year-old diagnosed with first-episode #depression is expected to live a decade less. https://t.co/85kYDgWXpb

Less family, less love, less music, fewer books...

One of the reasons I work with the @BrainDrugsMDD study on improving treatment. #precisionmedicin #mentalhealth

[Kristian RJ @K_RJensen]

We are amassing a large cohort of participants in our @BrainDrugsMDD study 🧠

Our cohort of students is also growing!
Two med students on the project defended their theses 👩‍⚕️👩‍⚕️✨

Looking forward to help them publish their works on #depression, #neuroticism & #sexhormones 📝

[Kristian RJ @K_RJensen]

🙋New hypothesis-generating paper out on the effects of The Pill on Dynamic Brain States and Network Modularity
https://t.co/gQAOR8tWpW

With @D_E_McCulloch, @SoerenVL, @anders_s_olsen, @Bruzzone_sep, @fisherpm1 and @vibefrokjaer at @CopenhagenNeuro 💊🧠#OralContraceptive 🧵

[Kristian RJ @K_RJensen]

What am I doing?
Oh, just establishing a 1200 large multi-modal neuroimaging cohort of patients with #depression in Copenhagen, that I follow for two years to predict treatment outcomes and guide future treatment.
Preparing a protocol paper to share soon. ✍️