Jonas Svensson

Psychiatrist, PhD. Moving towards aging research. Postdoc at Copenhagen University Hospital. PET research (brain imaging, not cats and iguanas)

[Robert Wright @robertwrighter]

Happy pub date to me! My book on AI is now available. If you want to ask questions about it before buying, just click reply. (And feel free to retweet!) The link to Amazon is in my bio.

[Jonas Svensson @jaralaus]

@MartinBJensen Mechanistic interpretability (in the setting of geroprotection trials) for fluid biomarkers will be challenging imo.

Biomarkers based on medical imaging allows for straightforward interpretation and are generally closer to FDA relevant outcomes. See:

https://t.co/o9YZx5EYA0

[GeroScience @GeroScienceAGE]

📢New Open🔓 Access Paper Alert

“Pharmacokinetic analysis of intermittent rapamycin administration in early-stage Alzheimer’s Disease” by Helen Annervik Wallgren & Jonas E. Svensson (@jaralaus) et al.

This open-label pilot study explored weekly oral doses of Rapamycin (7 mg or less) over 26 weeks in patients with early-stage Alzheimer’s disease.

Read full paper here:
🔗 https://t.co/xaxyGoDB70

#AlzheimersResearch #Rapamycin #Pharmacokinetics #GeroScience #mTORInhibitor

[Jonas Svensson @jaralaus]

@ladanuzhna That kind of move warrants a square worth of lateral shift in the researchers alignment chart imo.

[Lou Almskog @loutusblomman]

New review explores immunothrombosis vs. thromboinflammation - when immune cells form clots to trap pathogens vs. when existing clots drive inflammation. #immunothrombosis #thromboinflammation

https://t.co/vNfJKI1Tew

[RDoerfel @RPDoerfel]

I'm happy to share our latest pre-print on assessing the clinical validity of brain age as a biomarker of aging-related diseases and structural and cognitive decline in the brain!
https://t.co/Yh8ghBkPX3
(1/7)

[Tymofiy Mylovanov @Mylovanov]

Zelensky pushes back on Trump with facts, not rhetoric.

Zelensky: The U.S. has provided Ukraine with $67 billion in military aid and $31 billion in budget support.

Trump’s $500 billion fossil fuel claim isn’t a serious conversation. 1/

[Jonas Svensson @jaralaus]

Perhaps of interest for @MartinBJensen @StevenAustad @mkaeberlein @j_n_justice @agingdoc1 @Aging_Scientist @NirBarzilaiMD @statto ?

[Jonas Svensson @jaralaus]

🧵 NEW PAPER: A framework for using medical imaging to evaluate geroprotective interventions in humans. We outline how this could provide mechanistically interpretable outcomes in early phase clinical trials.

https://t.co/F8HWa4cdAU

[GeroScience @GeroScienceAGE]

📢New open🔓 access article proposes a battery of medical imaging protocols, including #magneticresonanceimaging, #positronemissiontomography, #computedtomography, and #opticalcoherencetomography, to assess age-related processes preceding #diseaseonset.

In vivo medical imaging for assessing geroprotective interventions in humans by Jonas E. Svensson (@jaralaus), Martin Schain & Pontus Plavén-Sigray.

https://t.co/nbnDW9IKhY

#Biomarkers #geroprotection #drugdevelopment #agerelateddisease #imagin

[Jonas Svensson @jaralaus]

9/ We are piloting a version of the imaging battery suggested above in our clinical trial of rapamycin in early-stage Alzheimer’s disease patients (also our submission to the XPRIZE Healthspan competition). https://t.co/krEahQWjNe

[GeroScience @GeroScienceAGE]

📢New open🔓 access article proposes a battery of medical imaging protocols, including #magneticresonanceimaging, #positronemissiontomography, #computedtomography, and #opticalcoherencetomography, to assess age-related processes preceding #diseaseonset.

In vivo medical imaging for assessing geroprotective interventions in humans by Jonas E. Svensson (@jaralaus), Martin Schain & Pontus Plavén-Sigray.

https://t.co/nbnDW9IKhY

#Biomarkers #geroprotection #drugdevelopment #agerelateddisease #imagin

[Jonas Svensson @jaralaus]

@marton_mes @NornGroup If so you may have identified the first component in your phase 2 imaging battery

[Jonas Svensson @jaralaus]

@marton_mes @NornGroup Yes, take one step back from the endpoints you ar proposing in your piece and ask what age related pathological process(es) preceeds this condition? Is the condition unlikely in absence of the process? Is the process happening in most elderly ppl and quantifiable using imaging?