Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM

Longevity medicine best practices | healthspan | precision medicine | bio/acc | consulting @

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

“Can We Reverse Aging?” is our episode title. My answer: not yet with today’s science. Maybe someday.

I joined @DarshanShah_MD to discuss slowing aging and extending healthy lifespan.

I hope you’ll watch the full conversation. Thanks for your support!

https://t.co/MABUJbhfOO

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Scientists turn blood-cell precursors from an 80-year-old donor into neural stem cells with epigenetic age below 20; 100-day process reveals cellular rejuvenation could aid aging and Alzheimer's research

https://t.co/mzbdhetDfs

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

McLean Hospital to establish new clinical and research center with $20 million investment as Global Network for the Advancement of Metabolic Psychiatry (Metpsy) launches

👉 Metabolic Psychiatry👨‍⚕️

https://t.co/MzdFr4iEEZ | @ChrisPalmerMD

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Merck/Moderna cancer vaccine cuts melanoma death or recurrence risk by 42%, shares fall

🔘 "Combination also reduced risk of cancer spread by 38% in study of more than 1,100 patients
🔘First late-stage data showing a personalized cancer vaccine improved outcomes when added to immune checkpoint inhibitor
🔘US regulatory filing in the works; Moderna expects 2027 launch"

https://t.co/MZvOS20BNu

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Foundation artificial intelligence models for health recognition by use of face photographs (FAHR-Face): a model development and validation study

“A single foundation model can generate inexpensive, scalable facial biomarkers that capture both biological ageing and disease-related mortality risk.”

https://t.co/unQgPWhF8V

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Scientists Reverse 60 Years of Cellular Aging: What a New Stem Cell Study Found

🔑"The Key Finding: More Than 60 Years of Epigenetic Rejuvenation..."

👉https://t.co/CK0efevx2k

👨‍⚕️Their study included donor-derived cells from individuals as old as 101....

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Protracted Fate Acquisition and Epigenetic De-Aging During Induced Neural Stem Cell Conversion of Human Blood Cells

👉"... Our conversion system could also serve as an alternative to partial or interrupted iPSC reprogramming in the context of cellular de-aging."

https://t.co/ZWBcZwuofD

👨‍⚕️"Here, we used overexpression of the two reprogramming factors SOX2 and cMYC to generate iNSCs from erythroid progenitors of donors ranging from neonatal to 101 years of age...

The results of our study show that direct conversion of peripheral blood-derived EPCs into iNSCs is associated with pronounced epigenetic de-aging. iNSCs generated via temporary overexpression of SOX2 and cMYC retain less than 5% of the DNAm age of their original blood cells, which were obtained from donors aged 0 to 101 years of age..." 🧪

@Aging_Cell | @AgingCell

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

The Role of Intermittent Fasting in Rheumatoid Arthritis—A Scoping Review

"Conclusions: The available evidence suggests that intermittent fasting may represent a promising, nonpharmacological strategy to support the treatment of RA, particularly in terms of improving immunometabolic parameters and subjective disease symptoms. However, due to methodological limitations and the lack of long-term studies, further well-designed randomized clinical trials are needed to evaluate the efficacy and safety of IF in this population..."

https://t.co/gkKkyIUrht

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Supplementation With Ketogenic Precursors Enhances Virtual Reality Shooting Performance During Sleep Restriction: A Randomized, Placebo-Controlled, Crossover Trial

"A transient state of nutritional ketosis enhanced virtual reality shooting performance both before and after short-term sleep restriction."

https://t.co/cxYHJI5vmM

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

The Effect of Daily Low Dose Tadalafil on Cerebral Perfusion and Cognition in Patients with Erectile Dysfunction and Mild Cognitive Impairment

“The results of this prospective clinical study suggest that daily use of tadalafil 5 mg increases some regional CBF and improves cognitive function in patients with ED and mild cognitive impairment.”

https://t.co/XNLwZ9jKaP

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Decoding Vascular Senescence: Cellular Insights and Therapeutic Strategies

https://t.co/c6TYNr0aAp

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Sex-Specific Neurogenic and Cognitive Responses in a Murine Model of Accelerated Aging

“ER272 was associated with improved cognitive performance and preservation of multiple neurogenic parameters in males but showed limited effects in females.”

https://t.co/ApoVVo7nXj

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

“Can We Reverse Aging?” is our episode title. My answer: not yet with today’s science. Maybe someday.

I joined @DarshanShah_MD to discuss slowing aging and extending healthy lifespan.

I hope you’ll watch the full conversation. Thanks for your support!

https://t.co/MABUJbhfOO

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Health Related Quality of Life and Personality Characteristics for Aging Well: Evidence from the Sardinian Blue Zone

💡"the combination of adaptive personality traits and coping resources promotes a more active lifestyle, providing insights into the mechanisms of successful aging."

https://t.co/HXA27H2s4A

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

'Low-Oxygen' Drug Combination Reverses Parkinson's Symptoms in Mice

https://t.co/u649778P9h

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Microsoft’s Mustafa Suleyman says its AI outperforms doctors on hard cases as he chases ‘medical superintelligence’

https://t.co/cyTsf8JgwC

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

@Medscape

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Longevity Boom: How to Respond When ‘Normal’ Isn’t Enough

https://t.co/cdhqWrzghT

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

ADHD Drugs May Reduce The Risk of Early Death, Major Study Finds

https://t.co/INyYeJvVw2

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

The FOXO-aging axis: Epigenetic insights and chromatin mechanisms

“… Chromatin context-specific FOXO targeting may improve anti-aging therapy...”

https://t.co/f3cD9pyaFd

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

@biogerontology First time in Boston was very successful. Looking forward already to 2027!