David Sinclair

Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan

[David Sinclair @davidasinclair]

Breaking
https://t.co/1PsQ4RX1Ex

[David Sinclair @davidasinclair]

Surprised @TheLancet published such unscientific polemic. This on the heels of the new ER-100 results reminds me of when @NYT predicted powered flight could take a million yrs, just 69 days before the Wright brothers flew.

“Several renowned experts told me” is what people write when they lack evidence. Expect more articles from the establishment as we make progress. People often fear what they don’t understand.

ICYMI:
“There are two delusions driving the world of longevity: the first is that ageing in humans is as malleable, or plastic, as it is in roundworms, fruit flies, and mice. The human body, the product of millions of years of evolution, is not, as our tech overlords believe, a programmable dataset. Several renowned biogerontologists told me that a significant biotech mediated expansion of human lifespan is unlikely in the foreseeable future: the longevity industry is a goldrush without gold. The second delusion is that longevity is primarily a scientific, or medical, concern. It is not.” 🙈

[João Pedro de Magalhães @jpsenescence]

"The longevity industry exists to exploit humanity, not to save it." - Seamus O'Mahony writes @TheLancet

Or, as he puts it, "the longevity industry is a goldrush without gold."

Talk about throwing out the baby with the bathwater!

Of course, the field is drowning in hype and commercial interests pushing unproven interventions. But that doesn't detract from the fact that slowing human aging - even if slightly - would have enormous health and medical benefits.

Manipulating human aging may prove harder than many in the field currently promise. But aging is no doubt malleable, so let's not lose sight of the field's long-term transformative potential.

The challenge is to tell hype from science, not to dismiss the science because of the hype.

[David Sinclair @davidasinclair]

It’s a privilege to get cancer. Not everyone gets to get cancer

[Lancesico 🇱🇨 @Bornakang]

Cameron Diaz said, "There's no such thing as anti-aging. We're all aging, period... It's a privilege to get older, not everybody gets to get older."

[David Sinclair @davidasinclair]

@cremieuxrecueil Working on it

[Lifespan @JoinLifespan]

Peptides are everywhere, but “peptide therapy” can mean anything from an FDA-approved medicine to an untested vial labeled “For Research Use Only.” What do we actually know about the compounds people are injecting? https://t.co/KmB3OLTAE8

[David Sinclair @davidasinclair]

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner
https://t.co/oUfOMz7BCR

[Jesse Morse, M.D. @DrJesseMorse]

For NAD+ users: NMN and NR didn't extend lifespan here, and the NIH's ITP found the same for NR.

Small arms, so not the last word. But there's still no good evidence that NAD+ precursors extend mammalian lifespan.

An important note to make.

[David Sinclair @davidasinclair]

@DrJesseMorse Small arms 🦖
https://t.co/oUfOMz7BCR

[David Sinclair @davidasinclair]

@biogerontology

[David Sinclair @davidasinclair]

True

[Marcos Arrut @MarcosArrut]

Rejuvenation without the loss of cellular identity.
That is the fundamental problem of cellular reprogramming.
Once solved, anti-aging biology will usher in the brightest era in human history.

That's all.

[David Sinclair @davidasinclair]

Woohoo

[Life Biosciences @lifebiosciences]

Proud to be named one of @Fortune’s Best Workplaces in BioPharma 2026! This recognition reflects the people behind our mission and the collaborative culture driving our work to advance epigenetic restoration to reverse diseases of aging. View the list here:https://t.co/KQdxASzLkw

[David Sinclair @davidasinclair]

Yup

[Chubby♨️ @kimmonismus]

Next step: Longevity and Rejuvenation. We are almost there.

Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA.

The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.

[David Sinclair @davidasinclair]

Never thought to squeeze a cell

[Prof Steve Horvath @prof_horvath]

Squeezing a fibroblast nucleus for a moment opens chromatin at mappable loci. Yang Song and Song Li at UCLA aimed CRISPRa guides at exactly those spots. Fibroblast to neuron conversion went from under 3% to about 40%, with no virus. In aged mouse fibroblasts, the same mechanically enhanced Oct4 activation lowered DNA methylation age on the mouse skin clock, close to the level of cells from young animals. But global methylation also drops. so how much of this is rejuvenation rather than dilution is the open question. Title: Mechano-epigenetic enhancement of CRISPR activation of target genes fo… https://t.co/wXxMjPVl1d

[Lifespan @JoinLifespan]

Bowhead whales can live for >200 years - longer than any other known mammal on earth! 🐳

Enjoy more science cartoons in Lifespan Magazine: https://t.co/sDRKvMRlRj

[David Sinclair @davidasinclair]

Big congratulations to Dr. Christoph Gorgulla @StJude, a Lifespan Foundation Laureate, with a check for $100K to study AI-mediated drug design using quantum

Thank you to subscribers of LS Magazine, who help support the Lifespan Foundation & research like Christoph's 🙏

[David Sinclair @davidasinclair]

https://t.co/sUwFn561H1

[David Sinclair @davidasinclair]

So true - the Information theory of aging in 2008:

NAD+ ➡️ sirtuins ➡️ histone modification ➡️ epigenetic stability ➡️ cellular identity ➡️ slower aging

https://t.co/ntf8o5mTtv

[Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs) @biogerontology]

NAD boosting and epigenetic restoration are two levers aimed at the same aging biology. David Sinclair (Harvard Medical School) at #ARDD2026. Photos: https://t.co/vpNtq07ZfU

[David Sinclair @davidasinclair]

What great comments! Thanks all 🙏

[David Sinclair @davidasinclair]

It’s confusing. Some studies examine sildenafil (Viagra), others tadalafil (Cialis). So many new studies are indicating surprisingly positive effects on various organs & even immune cells fighting cancer. How about a new Lifespan episode called “What’s not to love?”

[WayneTheWebGuy @WayneTheWebGuy]

@davidasinclair On your latest Rogan podcast, you mentioned both Tadalafil and Sildenafil but it was confusing which one you were referring to at times. It might be worth a followup post to clarify your position on both. Thank you from a long-time follower and fan!

[David Sinclair @davidasinclair]

@ELMHEU Doubt it

[David Sinclair @davidasinclair]

There is no convincing evidence that low dose Cialis associated with altered lens proteins or causes cataracts. There are potential side-effects to discuss with a physician, like a potentially slightly higher occurrence of a “stroke in the eye” (NAION), as with GLP-1RAs

[Lina @Livingdadream22]

@davidasinclair Hubby started C 5 months ago now cataract? Any link to this being common ?

[David Sinclair @davidasinclair]

@AlexJColville @VentureCoinist @convergence__x Congrats Alex!