Kurdell Campbell

Mother, Doctor & Humanitarian. Transformational ER leader🇯🇲🇬🇧🇮🇳🇵🇰

[Kurdell Campbell @kaekae71]

@DrShashiVohra1 @nikitabier Hope you heal well🇯🇲

[Haji Siyamuddin ANSARI @DrsansariOrd]

Answer: B. Formation of γ₄ tetramers with markedly increased oxygen affinity and poor tissue oxygen release

Diagnosis

This newborn has Hb Bart's hydrops fetalis syndrome, the most severe form of α-thalassemia, caused by deletion of all four α-globin genes (--/--).

Why?

In fetal life, the major non-α chain is γ (gamma). When no α chains are available, excess γ chains combine to form:

Hb Bart's = γ₄ tetramers

These tetramers:

Have extremely high oxygen affinity

Bind oxygen tightly

Fail to release oxygen effectively to tissues

The result is profound fetal tissue hypoxia despite oxygen being present in the blood.

Consequences

Severe anemia

High-output cardiac failure

Generalized edema (hydrops fetalis)

Ascites

Pleural and pericardial effusions

Usually intrauterine death or death shortly after birth without intervention

Why the other options are wrong

A. β₄ tetramers → HbH disease (three α-gene deletions), not hydrops fetalis.

C. Reduced β-chain synthesis with excess α chains → β-thalassemia.

D. HbS polymerization → Sickle cell disease.

E. Defective heme synthesis with ring sideroblasts → Sideroblastic anemia.

Exam Pearl

4 α-gene deletions → Hb Bart's (γ₄) → Hydrops fetalis

3 α-gene deletions → HbH disease (β₄)

2 deletions → α-thalassemia trait

1 deletion → Silent carrier

✅ Correct answer: B.

[Acadoodle @AcadoodleMed]

10 Things You Need to Know about Arterial Blood Gas (ABG)
https://t.co/ukJ6BDOwer
#emergencymedicine #intensivecare #respiratory #respiratorycare #icu #nurses #icunurse #ecg #ekg #cme #cmeonline

[Vikaas Shandily @VikaasShandily]

Pulmonary Embolism (PE): Symptoms, Diagnosis & Emergency Treatment
#PulmonaryEmbolism #BloodClots #EmergencyMedicine #MedicalEducation #VikaasShandily

[Haji Siyamuddin ANSARI @DrsansariOrd]

The location and appearance are highly suggestive of an infraorbital dermoid cyst.

🔍 Why this fits best:

Congenital lesion presenting in infancy

Slowly progressive, painless swelling

Well-circumscribed subcutaneous mass

Typical location along embryonic fusion lines near the orbit

📌 Important differentials:

Deep infantile hemangioma → usually more compressible/bluish with Doppler vascularity

Dacryocystocele → more medial near the medial canthus

Rhabdomyosarcoma → rapid aggressive progression with proptosis/inflammation

🧬 Dermoid cysts are choristomas formed by trapped ectodermal tissue during embryologic closure.

\text{Embryonic fusion defect} \rightarrow \text{Ectodermal inclusion cyst (Dermoid cyst)}

📷 Best initial investigation:

Ultrasound with Doppler

CT/MRI if deep orbital extension is suspected

💡 High-yield pearl: Periorbital dermoid cysts classically occur at the frontozygomatic suture (superolateral brow), but infraorbital variants can occur along the maxillary-zygomatic fusion plane.

[Sulekha Tripathi @sulekhat95]

A man spends 50 years teaching at MIT.

He knows his time is running out.

So he records one last lecture — everything he knows, distilled into a single hour.

He died 5 months later.

This is that lecture.

The most important hour you'll watch this week. 👇
Bookmark it for later

[Emergency Medicine Journal @EmergencyMedBMJ]

#May2026 #OutNow

Lots of clinically relevant EM content this month covering 🚁 prehospital care, 🧠 diagnostics, 📚 education, and ⚡ systems redesign.

Well worth a read for anyone working in emergency care 👇

https://t.co/LnhpEelCGL

#EmergencyMedicine #FOAMed #EMJ

[Amal Mattu @amalmattu]

Saturday night shift @#foamed #WhiteBoardTeaching

[Nationwide90FM @NationwideRadio]

Jamaican Olympian Josh Kirlew delivered a standout performance at the recent Aquatics GB Championships, breaking his own national record in the 100-metre butterfly with a time of 53.24 seconds at the London Aquatics Centre.

READ MORE HERE: https://t.co/gHPwmlOdiD

[Dr Shashi Vohra @DrShashiVohra1]

This was staring in our faces…. and being ignored. 🤯

[Kurdell Campbell @kaekae71]

@amalmattu @UMEmergencyMed Love it!

[Kurdell Campbell @kaekae71]

@amalmattu @boggs328 @UMEmergencyMed Thanks for always stimulating those brain cells
Amal🇯🇲

[Amal Mattu @amalmattu]

Saturday night shift ⁦@UMEmergencyMed⁩ #foamed #WhiteBoardTeaching

[Andrew Holness @AndrewHolnessJM]

During my visit to Stony Hill yesterday, I had a chance to reconnect with one of my teachers from St. Catherine High School, Ms. Hyacinth “Esther” McLean.

Engaging with her brought back so many memories.

Teachers like Ms. McLean are the quiet architects of our future. They guide, inspire, and invest in young minds, often without recognition.

I am deeply grateful for her dedication and the lessons that have stayed with me all these years.

[Keith Siau @drkeithsiau]

This is Mariano Barbacid, a Spanish cancer researcher who recently made the news after finding a cure for an aggressive form of pancreatic cancer in mice. His lab developed a new triple therapy regimen targeting the KRAS cancer pathway, implicated in 90% of pancreatic cancers. The combination of daraxonsib, a RAS(ON) inhibitor, afatinib (EGFR/HER2 inhibitor) and SD36 (a selective STAT3 PROTAC) led to complete elimination of tumour cells over a 200 day study period, bringing much needed hope to this often devastating condition.

[Kurdell Campbell @kaekae71]

@Elonmusklona HOPE🇯🇲

[oDessa @oblessa]

Thank you @RollingStone 🖤

[Nationwide90FM @NationwideRadio]

The man who allegedly abducted the six-year-old girl from school in Clarendon on Tuesday, apparently dragged her through bushes to evade those searching for her.

READ MORE HERE: https://t.co/ZbvsWxxp1N

[JPS @myJPSonline]

A crash broke a pole last weekend. Normally, repairing this means a scheduled outage
Knowing you’ve waited long enough, our crews decided to work LIVE to keep your power ON during repairs.
We can't do this every time. Tek Time Drive! Accidents damage the grid & can slow us down