Naftali Kaminski

First Generation Physician-Scientist, & many other things. This account is Private - opinions and tweets do not represent any of the organizations I work with.

[Naftali Kaminski @KaminskiMed]

As a physician-scientist I feel that advocating for #ClimateAction, #GunControl #CleanAir, #healthcare #vaccines is not politics, it is a professional duty! @MichaelEMann articulates it beautifully #IfYouSeeSomethingSaySomething #MustRead #ThisIsOurLane https://t.co/RQA9VCR6Ke

[Naftali Kaminski @KaminskiMed]

Really cool “Trans-regulatory gene mapping prioritizes disease drivers in asthma”
👏🏼@XuanyaoLiu & team 👏🏼
See paper https://t.co/IKlSi0VrZx & super 🧵below 👇🏼

[Xuanyao Liu @XuanyaoLiu]

Our paper is out today in Cell, "Trans-regulatory gene mapping prioritizes disease drivers in asthma", https://t.co/EcuxU2XIO3 🎉 GWAS hands us thousands of disease-linked variants, but the genes that actually drive the disease often aren't the ones sitting at those variants.

[Xuanyao Liu @XuanyaoLiu]

For asthma it flagged 21 DPGs, many missed by standard methods (GWAS, burden tests, PoPS, TWAS). In CRISPR screens in lung epithelial cells and T cells, most led to changes in epithelial integrity or IL-13 production, a far higher hit rate than for other genes (e.g., GWAS genes)

[Xuanyao Liu @XuanyaoLiu]

We first tested it where the biology is already well understood: 27 blood traits. DANDELION's genes were enriched up to ~22x in known Mendelian blood-disorder genes, a sign it's finding real biology. Reassured, we turned it on a disease we understand far less: asthma.

[Xuanyao Liu @XuanyaoLiu]

So we built a method we call DANDELION 🌱 It follows the trail from a GWAS variant, to the gene it's quietly regulating from far away ("in trans"), to the disease. Combining that with rare-variant data, it spots close-to-disease genes other methods walk right past.

[Xuanyao Liu @XuanyaoLiu]

Those variants usually act from a distance, tuning other genes elsewhere in the network. The genes we really want are the ones closest to the disease risk itself, where the interesting biology (and maybe future therapies) tends to be. Those have been hard to find.

[Xuanyao Liu @XuanyaoLiu]

Our paper is out today in Cell, "Trans-regulatory gene mapping prioritizes disease drivers in asthma", https://t.co/EcuxU2XIO3 🎉 GWAS hands us thousands of disease-linked variants, but the genes that actually drive the disease often aren't the ones sitting at those variants.

[DFA New Haven @DFANewHaven]

Indivisible launches "Yale Don't Cave" billboards placed along I-95 around New Haven

[Naftali Kaminski @KaminskiMed]

ILD Docs!!!
Before going to proteomic/transcriptomic blood markers - check your patients' CBC!!!
In all ILD's ⬆️ Neutrophils = ⬇️ outcome.
In IPF ⬆️ monocytes.
Is it time for prospective trial of clinical impact?
👋🏼👋🏼 @RamiU29442887 & team ! https://t.co/9ZLMLHkVFG

[Naftali Kaminski @KaminskiMed]

The best breakfast in the greater New Haven area just got even better. Saray Bakery in Orange opened their expanded renovated space and added a superb Pide collection to the menu. You order Turkish breakfast & the table fills up.
Highly Recommended !!!
#BestBreakfast
#NewHavenCT

[Claudia Sheinbaum Pardo @Claudiashein]

En el Día Internacional de los Pueblos Indígenas, propusimos, por justicia, cambiar el nombre de Paso de Cortés por Paso de los Pueblos Indígenas, origen y fuente de nuestros valores.

Hoy también realizamos la Jornada Nacional de Reforestación. Recordamos que honrar nuestras raíces también significa sembrar y cuidar la tierra que nos da vida. 🌳

[Naftali Kaminski @KaminskiMed]

The best breakfast in the greater New Haven area just got even better. Saray Bakery in Orange opened their expanded renovated space and added a superb Pide collection to the menu. You order Turkish breakfast & the table fills up.
Highly Recommended !!!
#BestBreakfast
#NewHavenCT

[Naftali Kaminski @KaminskiMed]

Best Connecticut politics tweet of the year 👇🏼

[DFA New Haven @DFANewHaven]

.@DouthatNYT lives a few miles from me in an area that is if anything a model of civic virtue, not "collapse," and if Ned Lamont is an avatar of "doctrinaire progressivism" then I'm Frank Pepe and Josh Elliott is my wife Filomena

[Hao Yin @HaoYin20]

Drug2Cell

https://t.co/p1HA0xr5u1

Drug target discovery using single-cell/-nucleus transcriptomics data

Parse ChEMBL database (>24 M bioactivity records) into drugs & their targets

Per-cell scoring + Marker enrichment

@kazukane @teichlab @Nature 2023
https://t.co/Pk0VuCZYEj

[Yale Internal Medicine @YaleIMed]

Stories of medical emergencies, shared meals, SpaceX, new motherhood, gender roles, and family complexities were among those shared during the 10th Annual Stories of Yale Internal Medicine MGR.

Read the brief glimpses of the stories in the article below.
https://t.co/C9aZhc43bC

[Matthew Herper @matthewherper]

NIH plans to block international researchers on visas from accessing key funding avenue https://t.co/3i55B5qmIM

[Naftali Kaminski @KaminskiMed]

😡👇🏼

[Jerome Adams @JeromeAdamsMD]

Can’t eat salads (explosive diarrhea). Eggs are risky and now jalapeños too (salmonella). Beef is under threat from screwworm.

RFK has spent months lecturing us to “eat real food…” yet under his watch & cuts, real food keeps disappearing due to uncontrolled outbreaks. 🤷🏽‍♂️

[Brian Feeley @DrBrianFeeley]

Our paper in @aaas STM.
We mapped the fibroadipogenic progenitor populations in human rotator cuff muscle at single-cell resolution — and found that a DLK1⁺ subpopulation acts as a brake on fat formation.
https://t.co/43kzDGkUO6

[Naftali Kaminski @KaminskiMed]

@SyedAAhmad5 Great question. Current model not sustainable. Not for institutions, not for clinicians, not for researchers, not for educators, & 😡 not for patients. Not sure there’s an answer. Maybe this is where most energy, intellect & creativity should be spent ? redesigning a new system?

[Abhimanyu Mahajan @AMahajanMD]

@SyedAAhmad5 Should leadership divert money from investments with poor ROI?

U.S. nonprofit hospitals collectively spent > $7.8 billion on management consultants from 2009-2023 with no meaningful changes in finances, operations or quality of care.

https://t.co/tNMiVNrS4g

[Naftali Kaminski @KaminskiMed]

A note to those claiming to speak for progressive Jews. Please stop telling us how to criticize Israel ‘without’ feeding antisemitism.
Your policing of what should be said about Israel, your conflation of Jewishness with Zionism is what feeds antisemitism.
Enough is enough.