Beth Zupec-KANIA, RDN, CD

Registered Dietitian Nutritionist, designer of KetoDietCalculator, medical author, speaker, consultant to The Charlie Foundation, Keto Live Europe, Glut-1 Found

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@metcoalition When you've lived long enough to know that the American diet has changed drastically since the 1970s paralleling the decline in health of our nation you know that things have got to change.

[Coalition for Metabolic Health @metcoalition]

At the Coalition for Metabolic Health, we're working to address America's chronic disease crisis. Learn more about our mission to make metabolic health mainstream—and hear directly from some of our experts—in our new video:

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@Metabolic_Mind @bschermd The long awaited consensus report is AVAILABLE to all!

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

We’re 5 days into the Healing Depression retreat and everyone is making ketones ! https://t.co/uMtWuvhTy6

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@janellison The erroneous message of saturated fats as bad health needs to be abolished.

[Metabolic Mind @Metabolic_Mind]

Dr. Lori Calabrese discusses how ketones can revolutionize health by enhancing mitochondrial function. Nothing else in psychiatric care does this quite like it! Watch the full interview for groundbreaking insights. 🎥🧠 #PsychiatricCare

https://t.co/Wewmqj7VHX

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@Metabolic_Mind Its soooo good to know that we can improve our brain function.

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

Ketogenic Diet, Exercise Effective First-line Treatments for Narcolepsy https://t.co/wKK8FJ4sNC https://t.co/wKK8FJ4sNC

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@GeorgiaEdeMD Glucose spikes in the brain lead to inflammation - there's a remedy!

[Columbia Psychiatry @ColumbiaPsych]

Mitochondria increase their activity level when we are having positive life experiences, according to recent research from @CarolineTrumpff & @MitoPsychoBio.

Trumpff spoke with @sciam about the implications of the findings: https://t.co/kjvkMEYtgD

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@bigfatsurprise @GovWesMoore @MDHealthDept @bschermd @Metabolic_Mind @janellison @UMmedschool @ProfDeannaK @taccommunicate We the people want this study to proceed.

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@ChrisPalmerMD How can an evidence based treatment for a serious mental health condition be withheld without explanation? Signed, donated, shared.

[Chris Palmer, MD @ChrisPalmerMD]

PLEASE HELP! Sign this petition.

The Maryland Health Secretary has halted an ongoing, privately-funded, inpatient study of a medical ketogenic diet for treating schizophrenia for no clear reason.

People with schizophrenia deserve better treatments.

https://t.co/GBixi820wh

[Nicole Laurent, LMHC @KetoCounselor]

Study Title: Recovery from Mental Illness with Ketogenic Diets: A Qualitative Retrospective Analysis
#ketogenic #research #qualitative #mentalhealthmatters #psychology
https://t.co/5nJav2ukil

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@IainCampbellPhD @LWSchizophrenia Thank you Helen for your excellent contribution to ketogenic therapies; application, research and leadership.

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

@Metabolic_Mind Can't wait for this tool! It will improve the use of low-carb and keto therapies by providing instant feedback and allow for modification of diet/lifestyle to get the best benefits.

[Beth Zupec-KANIA, RDN, CD @KaniaZupec]

I agree and have first-hand experience in transitioning women with AN from their high-carb diets to keto with incredible results.

[Metabolic Mind @Metabolic_Mind]

"Treatment-resistant: These two words should never be used together for mental illness or any illness, because it puts the blame on the patient & on the family. And Matt did not fail treatment, treatment failed Matt. They weren't the right treatments." -@janellison

[Nick Norwitz MD PhD @nicknorwitz]

🚨Lean Mass Hyper-Responder #LMHR Overview 🚨

The discussion around LMHR is increasing. That’s good. I wanted to take a moment compile potentially useful links and references. What follows:

👉Review of terms (#LMHR and #LEM)
👉Videos covering the Lipid Energy Model and phenomenon related to #LMHR.
👉10 references to peer-reviewed publications

#LMHR: A phenotype defined by LDL-C ≥ 200 mg/dl, HDL-C ≥ 80 mg/dl, TG ≤ 70 mg/dl.

NOTE: There is no threshold for BMI or body fat. “Lean” refers to the association between this lipid triad and being leaner (see video 4 and ref 4 in list below). More specifically, the LEANER one is on a very low-carb diet, the HIGHER LDL-C tends to be, as part of a high LDL-C, high HDL-C, low TG pattern that constitutes a metabolic fingerprint, of sorts. This appears to be a dose-response relationship.

#LEM Lipid Energy Model is the mode that explains the LMHR phenotype and related phenomenon. It is not “proven,” but has been effective in making accurate bold predictions.

🚨Some (tip of the iceberg) videos
Lipid Energy Model: https://t.co/gI3ZpGcrQv
OreoVsStatin: https://t.co/NYI7XrXwRV
3 month ‘update’ https://t.co/Wjz2wVmvx4
41 RCT Meta: https://t.co/Cdxed7DEVg
ApoB and ACM: https://t.co/95JGYIfWnj
LMHR confusion: https://t.co/JeYotymHl7
Not the saturated fat: https://t.co/o7bgj84NZ0
How to Lower LDL based on etiology: https://t.co/Co38hZeO1O
Convo with @Physionic_PhD: https://t.co/hJXYWyI4f2
Metabolic Link @DominicDAgosti2: https://t.co/1UVkQ3qtu3

🚨Publications. #4 is Meta of RCTs. #8 is #LEM.

(1) Budoff M, Manubolu VS, Kinninger A, Norwitz NG, Feldman D, Wood TR, Cury R, Feldman T, Fialkow J, Nasir K. Carbohydrate restriction-induced elecations in LDL-choelsterol and athetosclerosis: The KETO trial. Metabolism2024. doi: 10.1016/j.metabol.2024.155854.

(2) Javier DA, Manubolu VS, Kinninger A, Norwitz NG, Aldana JB, Ghanem A, Ahmad K, Vicuna WD, Hamidi H, Bagheri M, Villanueva B, Flores F, Hamal S, Feldman D, Budoff, MJ. The impact of carbohydrate restriction-induced elevations in LDL cholesterol on progression of coronary atherosclerosis: the ketogenic diet trial study design. Coronary Artery Disease 2024; doi: 10.1097/MCA. 0000000000001395

(3) Norwitz NG, Cromwell WC @Lipoprotein. Oreo cookie treatment lowers LDL cholesterol more than high-intensity statin therapy in a lean mass hyper-responder on a ketogenic diet: A curious crossover experiment. Metabolites. 2024; doi: 10.3390/metabo14010073
*Altmetric 1980 (top 0.02% of all >25M papers ever tracked)

(4) Sota-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a meta-analysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009
*In a meta-analysis of 41 RCTs, published in a top nutritional journal, we show that BMI is a major source of heterogeneity in LDL cholesterol response to carbohydrate restriction, far more so than saturated fat.

(5) Cooper ID, Sanchez-Pizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, Sota-Mota A. Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Front Endocrinol 2023; 14:1-7. doi: 10.3389/fendo.2023.1326768

(6) Norwitz NG, Mindrum M, Giral P, Kontush A, Soto-Mota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyper-responders on low-carbohydrate diets deserve urgent clinical attention and further research. J Clin Lipidol 2022; 16:765-768. doi: 10.1016/j.jacl.2022. 10.010

(7) Feldman D, Huggins S, Norwitz NG. Short-term hyper-caloric high-fat feeding on a ketogenic diet can lower LDL cholesterol: the cholesterol drop experiment. Curr Opin Endocrinol Diabetes Obes 2022; 29:434-439. doi: 10.1097/MED.0000000000000762

(8) Norwitz NG, Soto-Mota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydrate-restricted diets. Metabolites 2022; 12:460. doi: 10.3390/metabo12050460

(9) Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL-cholesterol with a carbohydrate-restricted diet: evidence for a “lean mass hyper-responder” phenotype. Curr Dev Nutr 2021; 6:nzab144. doi: 10.1093/cdn/nzab144

(10) Norwitz NG, Soto-Mota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyper-responder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Front Endocrinol 2022; 13:830325. doi: 10.3389/fendo.2022.830325

@realDaveFeldman @AdrianSotoMota