We tested nanoparticle formulated alendronate to achieve a high drug load in liver for antifibrotic treatment:
"pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages"
https://t.co/a6aeaqq5dS
💉 Albumin duration & AKI response in cirrhosis
Eva M. Schleicher (Mainz) – #EASL2025
🕒 24h albumin new rule questioned
🏆 EASL AKI response definition wins
📈 20% of 24h NR improved at 48h
⚖️ Early vs late responders: Same mortality
🚨 Cr ↑ >16% @24h → terlipressin!
👇
Incorporating the use of the Clinical Frailty Scale in clinical practice can help to identify patients with cirrhosis who may be at a higher risk of developing hepatic encephalopathy. @EvSchleicher@kaps_leonard@schattenbergJ@SJGairing#GItwitter
https://t.co/dTT1r7sGIx
Tesla Full Self-Driving capability demo in Austin
FSD capability features use vision neural networks to perceive & understand the world, just like humans do.
Via our unique fleet learning approach, we are able to collect anonymized data from our vehicles—meaning the neural nets have learned from a few orders of magnitude more driving scenarios than the average human driver (including unusual & weird ones!)
CAF as key target for antistromal therapy in liver cancer!
Targeting Cancer Associated Fibroblasts in Liver Fibrosis and Liver Cancer Using Nanocarriers https://t.co/ol4DRlbInl via @MDPIOpenAccess
Symptom burden is significant in patients with PBC. Beside pruritus, fatigue was reported to be burdensome even though patients show an adequate biochemical response to UDCA!
https://t.co/RbWHthfrPZ
#AASLD 2019 #Nanoparticles#posterpresentation#Bundeswehr
Nice work of Niklas Choteschovsky presented by the AASLD this year. Nanoparticlur Alendronte showed an antibiotic effect in CCl4 liver fibrotic mice
A first of its kind public-private partnership with the Government of Ghana to improve the diagnosis and accelerate treatment for people with #sicklecell disease, including making medicine available to people diagnosed with the disease. Learn more: https://t.co/Im2gfBUwtr