“Don't Give Up” is from Peter Gabriel’s 1986 album So. Featuring Kate Bush, the poignant duet was inspired by the economic hardship and unemployment affecting Britain during the 1980s. It reached #9 on the UK Singles Chart, while helping establish So as Gabriel's most commercially successful album, reaching #1 in the UK and #2 on the US Billboard 200.
Gabriel originally approached Dolly Parton to sing the female lead, but after she declined, he enlisted Kate Bush.