Antoine

Genetics, etc

[Antoine @kaskarn]

@heisei_ramen @P0ssumActual @LokiJulianus If only we were so based

[Antoine @kaskarn]

@NikoMcCarty Lol, lmao even

[Antoine @kaskarn]

@curiouswavefn @Nature You will sleep in ze pods you will eat ze rinvoq and be happy

[Antoine @kaskarn]

@curiouswavefn @Nature Bro thinks anthropic will give him TYK2i IPable conformations for free

[Antoine @kaskarn]

@MartinShkreli most diseases are caused by small changes in TF expression. we can't solve a lot of diseases because we see a 10% upregulation in 40 TF, a 30% upregulation in another 30% TF and 20% deregulation in another 5.

:)

[Antoine @kaskarn]

@MartinShkreli Not obvious to me that targets are as exhausted as the field believes (has clindev matched target-indications well in the aggregate? Nah)

if we can bump any TF with sufficient cell type and context specificity though, cool. But I suspect their platform is messy af

[Dwarkesh Patel @dwarkesh_sp]

In medieval times, within the arms race of ever more demonic torture devices, some sadistic genius came up with the idea of the Little Ease.

This was a prison cell built so small in every dimension that a grown man could not stand upright in it nor lie down at full length nor properly sit.

The pain is relentless and without relief and inflicted by one's own body. Prisoners were known to go insane within a few days. A stay at the Little Ease was considered even more cruel than the rack, the thumbscrew, and the other ghoulish machinery of the Tower of London.

A breeding pig will spend her whole life in a version of that box.

These are social, roaming creatures (more intelligent than dogs) who will never leave this corset of steel.

They have been selectively bred to be bigger than their frames can support. Yet we put them in cells so confined that they cannot comfortably sit, and their attempts to do so (for example, by sneaking their limbs into adjacent stalls) reliably lead to fractures and sprains.

They cannot sweat, yet have nothing to roll around in to cool themselves off. Except their own manure, which (contrary to the common misconception) they are so averse to (thanks to their strong sense of smell) that new sows will often suffer from constipation to avoid soiling the space from which they eat and sleep.

Here is how the writer Matthew Scully described what saw at one of Smithfield’s “gestation barn”:

> “Sores, tumors, ulcers, pus pockets, lesions, cysts, bruises, torn ears, swollen legs everywhere. Roaring, groaning, tail biting, fighting, and other “Vices,” as they’re called in the industry. Frenzied chewing on bars and chains, stereotypical “vacuum” chewing on nothing at all, stereotypical rooting and nest building with imaginary straw. And “social defeat,” lots of it, in every third or fourth stall some completely broken being you know is alive only because she blinks and stares up at you … creatures beyond the power of pity to help or indifference to make more miserable, dead to the world except as heaps of flesh into which the [insemination] rod may be stuck once more and more flesh reproduced.”

—

The Save Our Bacon Act is trying to unroll the few state protections we have against this barbaric cruelty - for example California’s Prop 12 - which banned the sale of pork from pigs kept in gestation crates.

It’s incredibly important we don’t end up with this sort of federal preemption.

SOB will not only kill the most important animal welfare related laws in the US of the past decade, but more importantly, it will also restrict ALL future legislative progress (aka how the animal welfare movement has gotten its biggest wins).

The Senate is currently deciding whether to add the SOB Act to the Farm Bill.

With relatively little money now, we can discourage the most pivotal senators in the Ag committee from backing this amendment.

Defeating this bill is even more important given the amount of philanthropic funding I expect to come online in the next year or two.

It will plausibly be over 10x more expensive to repeal SOB than to prevent it from passing in the first place.

All that money that could be spent transforming our society's relationship to mass animal suffering will instead have to be spent just getting us back to where we are right now.

That's why money spent now fighting this bill (and I mean right NOW) is so effective.

If you’re in a position to donate six figures, please DM me.

[Antoine @kaskarn]

@Chudfish14921 @punch_puppy Dude cries himself to sleep watching Red Dawn every Saturday night

[Antoine @kaskarn]

@hanno_sauer Can't believe they award chemistry nobel prizes. What's next? Cooking? Fingerpainting? Wow look at me I can mix blue goop with green goop

[Antoine @kaskarn]

@RealPostFolder you're unironically low IQ if you think this actually happened

[Antoine @kaskarn]

@zaffagg3 What happens to the chonky unmarked sheep 🥺

[Antoine @kaskarn]

@cremieuxrecueil Hard to imagine insurance reimburse this when PCSK9 inhibitors are already famously tricky to prescribe

[Antoine @kaskarn]

@civilagain @evisdrenova (Conveniently ignores the thousand biotech startups which are literally one-trick ponies 👌)

[Antoine @kaskarn]

@Binnoreen @frombit3301 🤦‍♂️

[Antoine @kaskarn]

@bob674971282334 @Brad75138648402 @ylecun Stop. Read what he wrote. He wants me out permanently

[Antoine @kaskarn]

@bob674971282334 @Brad75138648402 @ylecun dude said 'If you aren't a citizen, get out'

[Antoine @kaskarn]

@Brad75138648402 @ylecun > Me, on a green card, with 2 American kids, in the US since I'm 15, married to an American wife, never broke a damn rule, wondering wtf I did to make you want to destroy my family

[Antoine @kaskarn]

@sam_d_1995 @chap42chap He far gone bro

[Antoine @kaskarn]

@leonVSevildead @LipotaAbdul See his pinned tweet, it gets worse