Dr. Catherine Tooke

Prize Fellow in Antimicrobial Resistance at the University of Bath. Investigating the mechanisms underlying beta lactam antibiotic action and resistance.

[Dr. Catherine Tooke @kcat_Tooke]

Delighted to see our latest work out in @J_A_C_S https://t.co/CkaSQzPurj. We use kinetics, crystallography and simulation to investigate carbapenem hydrolysis in the versatile KPC-2 beta-lactamase. @Spencer_D60 @Michaelbeer777 @phil_hinchliffe @SchofieldOxford @AdrianMulholla1

[Dr Emma Denham 👩🏻‍🦰🧬🧫🦠👩‍🔬🔬🥳 @Gingermicrobe]

Come and join us here in beautiful Bath @lifesciencebath where we have lots of exciting microbiology going on! If you’re in to Microbiomes then have a look at these new positions!

[Michael Beer @Michaelbeer777]

Out now in @ACSCatalysis, we show that active site electric fields are a determinant of carbapenemase activity in class A beta-lactamases. Led by @AdrianBunzel and Hira Jabeen! @AdrianMulholla1 @marcvanderkamp @Spencer_D60 @SWBio_DTP

https://t.co/seE1UXuY2I

[Dr. Catherine Tooke @kcat_Tooke]

An absolutely stellar morning session on the first day of the Great Wall symposium 2023! ... the location isn't bad either... #GWS2023

[Dr. Catherine Tooke @kcat_Tooke]

Another #PhD opportunity for Sept 2024 led by @Spencer_D60 to investigate B-lactam antibiotic action and resistance with a combination of structural biology and molecular simulations co-supervised by me, @marcvanderkamp and @AdrianMulholla1 ! https://t.co/gYseHSgHim

[[email protected] @marcvanderkamp]

#PhD opportunity for Sept 2024:
@GW4BioMedDTP project on overcoming Class C β-lactamase mediated #AntimicrobialResistance!
with @kcat_Tooke, @Spencer_D60, @AdrianMulholla1

Project: https://t.co/pQOE3zp9qq
DTP deadline Nov 1st

#BlackInChem particularly encouraged!

[Dr. Catherine Tooke @kcat_Tooke]

Very excited to start as Prize Fellow in Antimicrobial Resistance at the University of Bath today! @LifeScienceBath.

[Dr. Catherine Tooke @kcat_Tooke]

I had a great day at #ASMicrobe, some really interesting sessions and nice to present a poster on my KPC investigations ft. @Michaelbeer777 and @phil_hinchliffe from @Spencer_D60.

[Dr. Catherine Tooke @kcat_Tooke]

Spectacular talk at the 14th annual beta-lactamase meeting by Prof. Robert Bonomo. Beautifully putting current clinical challenges in perspective and demonstrating the urgency and need for a continuous BL inhibitor pipeline

[Pint of Science UK @pintofscience]

#pint23 is getting very close!
Science talks in relaxed atmosphere for 3 nights, come meet and chat with scientists! No science background needed.

🗓️22nd-24th May 2023
📍40 towns/cities across the UK
🗣️400 events
🐟🫀👩‍🔬👓📚🧠✨🧪🔭🥼🧫🦴

Book here 🎟️https://t.co/VYi31if9gr

[Dr. Catherine Tooke @kcat_Tooke]

@ProfRuthMassey @Dora_Bonini @alnaharialaa1 @SeanaDuggan @HenrikStrahl Amazing work @Dora_Bonini

[Ruth Massey @ProfRuthMassey]

Latest paper from the lab, work of @Dora_Bonini with help from @alnaharialaa1 @SeanaDuggan Tarci and @HenrikStrahl
Where we decipher how the tiny and tricksy MspA protein controls S. aureus virulence in such a pleiotrophic manner. 1/2

https://t.co/uWbbnE1y7K

[School of Cellular & Molecular Medicine @CMMBristol]

IT'S TODAY!! Jim is proving to be so popular, we have opened up a few more spaces for his inaugural this evening, click on the link below to book your place...

[Jordan Sealey @jordanesealey]

Fancy a pint? Join us in the pub for a pint (23rd May) where my colleagues and I will be giving talks at #pintofscience about the work we do on antibiotic resistance. Click the link for tickets and more info! #pintofscience #antibioticresistance #health
https://t.co/UoBlhno5YG

[School of Cellular & Molecular Medicine @CMMBristol]

We are excited to announce Prof Jim Spencer @Spencer_D60 will be presenting his inaugural lecture on Thur 4 May at 5.30pm, followed by a drinks reception.
Talk title: "How I learned (not) to stop worrying, and love bacteria."
Find out more & book for free: https://t.co/3yuJsX25Lr

[Dr. Catherine Tooke @kcat_Tooke]

@livinglondonhis @WaterstonesTCR Huge congrats Jack!!

[Michael Beer @Michaelbeer777]

Happy to have contributed to this, out now in @J_A_C_S, examining what defines KPC-2 beta-lactamase’s activity! Together with @kcat_Tooke @phil_hinchliffe @AdrianMulholla1 @SchofieldOxford @Spencer_D60 @SWBio_DTP https://t.co/oqZu1vo1YH

[Michael Beer @Michaelbeer777]

Out now in preprint! Led by @kcat_Tooke we use high resolution crystallography and QM/MM umbrella sampling simulations to explain KPC-2’s broad spectrum, carbapenemase activity @SWBio_DTP @AdrianMulholla1 @Spencer_D60 @phil_hinchliffe @SchofieldOxford https://t.co/a3vWZyTby1

[Dr. Catherine Tooke @kcat_Tooke]

Our latest work detailing how omega-loop stability and carbapenem acyl-enzyme tautomerisation define activity of the KPC-2 beta-lactamase is out in pre-print. https://t.co/P1xdNiR08G. @phil_hinchliffe @Michaelbeer777 @AdrianMulholla1 @Spencer_D60 @SchofieldOxford

[Dr. Catherine Tooke @kcat_Tooke]

Thanks Jim, it was a fab lab day out!

[Spencer Lab @Spencer_D60]

First summer lab day out since the BeforeTimes- tour of @PenderynWhisky, a walk and a wild swim in the wonderful Brecon Beacons. Thanks to the group for a great day!