John Kellum

[John Kellum @kellumja]

Listen to "Code Green or Code Greed? Dr John Kellum" by The Critical Care Commute Podcast https://t.co/fNLrcR93pk

[AJKD @AJKDonline]

Remote Ischemic Preconditioning: Is This Star Still Rising?

https://t.co/yHotMYpbo2 (FREE)

@kellumja @DanaFuhrman4

[John Kellum @kellumja]

Somehow I missed this review from last March. Obviously, I think it's spot on!
Book Review: Code Green How the Big Lie in Healthcare Affects Us All by Kellum John - PMC https://t.co/E583278yP6

[John Kellum @kellumja]

How is possible that ICU physicians still believe that serum creatinine quantifies kidney function when nephrology adopted eGFR 20 years ago? How is it OK that a woman must lose 2.5x as much kidney function as a man just to get 1 SOFA point for renal? https://t.co/FV16sjvkID

[John Kellum @kellumja]

Another tripute to a giant in our field. Rest in peace dear brother. https://t.co/Vfw675nEN8

[John Kellum @kellumja]

TIMP-2 and IGFBP7 are stress markers for the kidney, no stress, no protection. Now the stage is set to do a large trial of RIPC using sevoflurane anesthesia and better yet we can also titrate RIPC to biomarker response. Precision medicine at its finest!

[John Kellum @kellumja]

Impact of propofol or sevoflurane on the renoprotective effect of remo... https://t.co/pCzx2U029x --This is a fascinating story. RIPC seems to work in some trials but not at all in others. Two big trials were negative so that's the end of story right? Not so fast. . .

[John Kellum @kellumja]

...It turns out that the big trials used propofol and there is body of evidence showing that this agent blocks the protective effect of RIPC. Now with this paper we show how. Propofol interferes with the release of TIMP-2 and IGFBP7 from the kidney in response to RIPC...

[John Kellum @kellumja]

@Tubulocentric Good thoughts. The kidney stress question we addressed by measuring TIMP-2*IGFBP7. We used a very high threshold so no question that these patients all had very high stress. The greater functional nephron mass is harder... all we can say is that the cohort was the same age.

[John Kellum @kellumja]

Funny thing. . . 7% of patients with sepsis have "Nephrons of Steel" and don't develop Acute Kidney Injury when by all accounts they should. These "AKI-resistant" humans may hold the key to AKI prevention and therapy. https://t.co/kuxb5g0s3m

[John Kellum @kellumja]

@pkguru10 @VicenzaCourse Some news today.. . https://t.co/UDmLqwOXWk

[John Kellum @kellumja]

After more than 5 years and nearly 15,000 patients screened, main results from Tigris are out! Precision medicine isn’t for the faint of heart! PMX Hemoadsorption to remove endotoxin is highly effective in this very select population https://t.co/UDmLqwOXWk

[John Kellum @kellumja]

Learn why sepsis criteria are grossly inadequate for capturing Kidney dysfunction. https://t.co/te0PlbVYJw

[John Kellum @kellumja]

As seen in other studies, about half of all patients admitted to the ICU develop AKI with about 2/3 stage 2-3. However only 12% of stage 2-3 are have persistent severe kidney dysfunction. Outcomes for these pts are far worse. Endpoint for drug trials?
https://t.co/TDpndW6jBC

[John Kellum @kellumja]

@JACCJournals

[John Kellum @kellumja]

https://t.co/ihfbQQDmvL
FACTCHECK “SGLT2 inhibitors result in “AKI” using KDIGO definitions yet confer undisputable benefits across a variety of settings.” FALSE

[John Kellum @kellumja]

Check out table 4. AKI rates were not different across study arms with the exception of DAPA-HF trial in which serious kidney events were actually less common with dapagliflozin compared to placebo (P=0.009). The claim that SGLT2 inhibitors cause AKI is demonstrably FALSE.

[John Kellum @kellumja]

See et al. Makes a compelling Argument for Clinician Autonomy, and Individualized Care in the ICU. https://t.co/hIxNQdgGzx

[John Kellum @kellumja]

We will never achieve our aspirations for a truly equitable society until those born into privilege see progress in absolute terms not just relative to people they believe they are superior to.