Sonic Pika

看片片、興趣：唱歌、羽球、 排球 很愛皮卡丘（沒有要換照、也沒有要約，虛情假意的太多）謝絕惡靈 已讀不回、不讀不回突然消失 明明人在卻不回覆、換照就消失等等 滾遠點

[Look at my shining eyes @GothicOrnate]

这样的相亲你怎么评论

[𝓣𝓸𝓪𝓷𝓷𝓮 ღˇ◡ˇ) @IDMTBR]

#Taiwan

台灣總有投降派愛說：「中國解放軍太強、台灣打不贏，不如早點談判求和」

請把這段美方專家的分析傳給他們看！

「如果世界上有一座天然要塞是絕對守得住的，那座要塞就是 #台灣！！！」

▫️▫️▫️▫️▫️▫️▫️▫️▫️▫️▫️▫️

為什麼台灣守得住？

1、連二戰美軍都放棄攻打台灣

2、80 年過去，登陸台灣只有難上加難

3、解放軍根本沒有實戰經驗

4、他們準備了 40 年，依然差得遠

感謝YTber「AI 101」完整翻譯訪談內容。拜託大家去看完整影片，連結放留言區👇

[魅力山西 @meilishanxi]

🎬2009韩国影片《食人猪》🐗

🤡深山里的三昧里村连续发生离奇碎尸案，凶手不是人，而是一头因栖息地被破坏、掘墓吃尸后嗜好人肉的变异巨型食人野猪😱🐷 #娜剧场 #韩国恐怖片 #食人猪

[CardiovascularCorner @TrackYourHeart]

Echocardiographic parameters suggesting pulmonary hypertension

How do you recognize PH on echocardiography?

The 2022 ESC/ERS Guidelines recommend assessing multiple parameters rather than relying on a single measurement.

Key findings include:
1️⃣ Peak TRV >2.8 m/s
2️⃣ RV/LV basal diameter or area ratio >1.0
3️⃣ Flattening of the interventricular septum
4️⃣ RVOT acceleration time <105 ms or mid-systolic notching
5️⃣ TAPSE/sPAP ratio <0.55 mm/mmHg
6️⃣ RA area >18 cm²
7️⃣ IVC >21 mm with reduced inspiratory collapse
8️⃣ PA diameter >25 mm
9️⃣ Early diastolic pulmonary regurgitation velocity >2.2 m/s

Importantly, TRV should not be interpreted in isolation. Additional signs from at least 2 different categories are required to modify the echocardiographic probability of PH.

Echocardiography estimates the probability of PH; right-heart catheterization is required for definitive haemodynamic diagnosis.

Source: 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.

[ゲルニカ @guernicass4]

一番くじ ドラゴンボール SPIRIT OF THE SAIYAN

10月17日発売予定
1回790円

ラストワン賞 孫悟空&孫悟飯 MASTERLISE PLUS

ラストワン賞には孫悟空と孫悟飯が筋斗雲に乗ってMASTERLISE PLUSシリーズに登場！

筋斗雲のボリューム感に加え、親子の絆が感じられるポージングで立体化され、空を駆けるような躍動感のある唯一無二のフィギュア!!

[上善若水 @SR18666]

现实是，这个弟弟会和家里人一起打压欺负姐姐

[我不姓阿 @muren_gang]

变成讨伐型人格有多爽！

[德扑小安 @luyanxiaoan]

当初借出去的钱，如今要回来了吗？

[Cell Metabolism @Cell_Metabolism]

New! Online now: A new name, an old crisis: Metabolic dysfunction at the core of polyendocrine metabolic ovarian syndrome https://t.co/nwwfKzqVEF

[Otto Huang  @OttoHuang120]

連 日本人 都知道 蔣萬安 特權自肥

[Winosaur @winosaur32286]

貓英所談的
也就是最近台北市所發生的事

權貴的小孩(比如蔣萬安的兒子)
依舊霸佔各種資源與好處

而民進黨則是希望把國家經濟紅利
轉為讓每個人都有一些機會

台灣到底能不能成為一個好的國家
或是走回威權極權的舊時代

要看選民的智慧了

#蔡英文

[ポケモン情報NAKAYAMA【非公式】 @pikachu_pcn]

ポケモン30周年記念
ピカチュウのぬいぐるみストラップ

いろんなピカチュウ 全30種

宝可梦官方旗舰店にて

[沃草 Watchout @watchoutTW]

今天是《舊金山和約》簽署 75 週年，這份文件是確立日本放棄臺灣、澎湖主權的關鍵。

然而，中國卻不斷宣稱擁有臺灣主權。

重回歷史現場，和約只寫了日本放棄主權，「根本沒說要交給誰」！這也是為什麼美國 AIT 與國務院會指責中國扭曲歷史。

臺灣的未來必須由臺灣人民自己決定。別忘了，我們還有機會用手中的選票，選擇自己的未來！

[遊戯王あんてな @yugioh_antenna]

【遊戯王ラッシュデュエル情報】「レギュラートーナメント」2026年10月からの景品を公開！ https://t.co/QQRSbI5BW5

[William A. Wallace, Ph.D. @WilliamWallace]

Most people who take CoQ10 think of it as an antioxidant. It is one. But that is not the most important thing it does.

CoQ10 is the only mobile electron carrier in the inner mitochondrial membrane. The electron transport chain has four protein complexes fixed in the membrane. Complex I accepts electrons from NADH. Complex II accepts them from FADH2. But neither can pass those electrons directly to Complex III. They hand them to CoQ10, which physically shuttles across the lipid bilayer to deliver them. Complex III passes them to Complex IV, which reduces oxygen to water and drives the proton gradient that ATP synthase uses to produce ATP.

Without CoQ10, the chain breaks between Complex I/II and Complex III. Electrons have nowhere to go. The proton gradient collapses. ATP production stalls. This is not an antioxidant function. This is the core mechanism of aerobic energy production.

CoQ10 is predominantly synthesized endogenously through the mevalonate pathway, the same pathway that produces cholesterol. HMG-CoA reductase is the rate-limiting enzyme. Statins inhibit HMG-CoA reductase. That is how they lower cholesterol. It is also how they lower CoQ10.

An updated meta-analysis by Qu et al. (2018) pooled 12 RCTs with 1,776 participants and found statins significantly reduced circulating CoQ10. The reduction was independent of statin type, intensity, or treatment duration. Both lipophilic and hydrophilic statins produced the same effect. This is consistent with what the biochemistry predicts: the pathway is shared.

On top of statin-induced depletion, CoQ10 in human heart tissue declines naturally with age. Kalén et al. (1989) measured CoQ10 concentrations in myocardial tissue and found levels peak around age 20, decline by more than 30% by age 40, and drop approximately 50% by age 80. The organ with the highest energy demand loses half its electron carrier over a lifetime.

A 2025 meta-analysis by Kovacic et al. (Journal of Nutritional Science, 7 RCTs, 389 patients) found CoQ10 supplementation significantly reduced statin-associated muscle symptoms measured by pain intensity. This is the most current pooled data on clinical outcomes.

One important nuance: while plasma CoQ10 depletion from statins is well established, whether intramuscular CoQ10 drops proportionally is inconsistent. Some studies found no change or even increases in muscle tissue CoQ10 during statin treatment. The plasma reduction may partly reflect reduced LDL particles, which are the primary carriers of CoQ10 in blood. The clinical significance of depletion beyond muscle symptoms remains debated.

Roughly 200 million people worldwide take statins. The mevalonate pathway that produces their target also produces the electron carrier their mitochondria depend on. The mechanism is not controversial. The clinical implications are still being defined.

Kalén et al., Lipids, 1989.
Qu et al., Eur J Med Res, 2018.
Kovacic et al., J Nutr Sci, 2025.

[William A. Wallace, Ph.D. @WilliamWallace]

Most people take their full magnesium dose in one sitting. The absorption data says that strategy may not “maximize efficiency.”

Fine et al. gave healthy subjects a standard meal supplemented with increasing amounts of magnesium. At the lowest dose (36 mg), 65% was absorbed. At the highest dose (1,009 mg), only 11%. The curve was not linear. It dropped steeply at first, then flattened. Their model explained it as two simultaneous processes: an active transport channel that saturates, plus a passive route that absorbs a fixed ~7% of whatever is present.

The active channel is TRPM6. It sits in the intestinal epithelium and actively pulls magnesium ions across the membrane. It works well at low concentrations but has a ceiling. Once it is saturated, additional magnesium can only cross passively between cells (paracellular transport), driven by the concentration gradient. That passive route never saturates, but it only captures about 7% of the dose regardless of how much is present.

This is why splitting a 400 mg dose into two 200 mg doses absorbs more total magnesium. Each dose stays closer to the steep part of the curve where TRPM6 is still contributing. One large dose overwhelms the active channel, and most of the magnesium passes through unabsorbed. The unabsorbed fraction is osmotically active, pulls water into the colon, and causes the loose stools people commonly experience.

A question that comes up: does the form of magnesium change this? The absorption curve from Fine et al. used magnesium acetate, which is highly soluble. The form determines how completely and quickly the magnesium salt dissolves and releases free Mg2+ ions in the gut. Oxide dissolves poorly at intestinal pH, so much of it never becomes available. Citrate, glycinate, and acetate dissolve more readily. But once the ion is free, it faces the same TRPM6 and paracellular bottleneck regardless of what delivered it. Form determines how much Mg2+ reaches the membrane. The curve determines how much of that gets through. A poorly soluble form at a high dose is the worst combination. A highly soluble form split across meals is the best.

The RDA for magnesium is 310-420 mg per day. NHANES data consistently shows about half of US adults fall short. Splitting the dose is free, requires no product change, and the physiology is clear.

Fine et al., J Clin Invest, 1991.

Schuchardt & Hahn, Curr Nutr Food Sci, 2017.

[Sonic Pika @kenpoke13]

@z9610z9610 原來你不喜歡色色嘛😅