Our latest paper linking the #metabolome#epigenome and #transcriptome to the #exposome (chemicals, diet, environment) in six populations of children across Europe https://t.co/fJR3E6oH6V
Our latest paper in which we show how targeting RNA splicing can impact tumour metabolism and could be a new way to treat an aggressive childhood cancer. Great collaboration with @ICR_London@MRC_LMS Congrats to @Artiska2 Anke Nijhuis and Orli Yogev https://t.co/lmfr8yLnLq
Reliable measurement of diet from self-report is notoriously difficult. Evidence from @BiBresearch & sister cohorts shows potential for urinary markers
Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health https://t.co/6fAVP6uJIa
The #ATHLETEproject follows thousands of mothers and children across Europe to measure how the #exposome affects their health. Find out more here https://t.co/vN3gAcDqz6
Pleased to announce our latest #exposome paper as part of the #ATHLETEproject, in which we define a metabolome signature of diet quality in children linked to metabolic health. Congrats to @AlexandrosSISK1 & @ChatziLab https://t.co/ixaeuzyz9Y
An international research team, including @hectorkeun and @AlexandrosSISK1 from S&C, has identified metabolic ‘signatures’ in urine that can determine the quality of diets in children across Europe and predict their metabolic health. https://t.co/scsZCZ0N7v
Very pleased to have contributed to this great paper from @auner_lab_ICL on stress resolution in multiple myeloma cells recovering from proteasome inhibition. Follow thread to find out out more 👇
How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵https://t.co/YxlYj7dP22
How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵https://t.co/YxlYj7dP22
Distinguishing between vaccine efficacy and effectivenesss, looking at relative risk reduction (RRR), absolute risk reduction (ARR) and numbers needed to vaccinate (NNV) https://t.co/XlAYMgt1RB @LancetMicrobe by @ElsTorreele@IIPP_UCL and colleagues
Another PhD that'll be formally advertised soon - this time through @STRATiGRAD Proj w/ Prof Iain McNeish @ImperialSandC & @AstraZeneca > biomarker discovery & instrument development for ovarian cancer. Interested or know anyone that might? Get in touch. RTs appreciated!
A big moment for me - 20 years ago today I started at @imperialcollege ! It has been a lot of fun, so lucky to have worked with so many brilliant and supportive colleagues. Thank you to all @keun_lab past and present👏you are amazing (And of course the best is yet to come... !)
Recently published in @BrJCancer:
Pre-clinical research demonstrates lactic acidosis in cancer induces Akt inhibitor resistance. Interfering with lactic acid uptake reversed resistance to the Akt inhibitor, uprosertib.
@keun_lab@imperialcollege
https://t.co/3RIALNgOSW
Our latest paper in which we show that lactic acidosis protects cancer cells from cell death induced by the pan-Akt inhibitor uprosertib, and how the effect can be reversed by metabolic inhibitors #cancermetabolism#tumormicroenvironment#drugresistance
https://t.co/X8wlBUseZM
Japan: Intercellular signal transduction during the assembly of slime mould cells • cAMP-sensitive fluorescent probes • signal is transmitted as a spiral wave within the group • amazing • via @kotapub https://t.co/CnKHtDN8yU
Our latest paper where we studied which microRNAs can be measured stably over time in serum, a factor in making them good biomarker candidates. What we found was a surprising link to maternally imprinted genes
#geneimprinting#microRNAs#biomarkers
https://t.co/gd6aLRkSE9