Keun Lab

Cancer Metabolism and Systems Toxicology lab group @imperialcollege #Cancer #Metabolism #Research

[Keun Lab @keun_lab]

Our latest paper linking the #metabolome #epigenome and #transcriptome to the #exposome (chemicals, diet, environment) in six populations of children across Europe https://t.co/fJR3E6oH6V

[Keun Lab @keun_lab]

Our latest paper in which we show how targeting RNA splicing can impact tumour metabolism and could be a new way to treat an aggressive childhood cancer. Great collaboration with @ICR_London @MRC_LMS Congrats to @Artiska2 Anke Nijhuis and Orli Yogev https://t.co/lmfr8yLnLq

[John Wright @docjohnwright]

Reliable measurement of diet from self-report is notoriously difficult. Evidence from @BiBresearch & sister cohorts shows potential for urinary markers

Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health https://t.co/6fAVP6uJIa

[Keun Lab @keun_lab]

The #ATHLETEproject follows thousands of mothers and children across Europe to measure how the #exposome affects their health. Find out more here https://t.co/vN3gAcDqz6

[Keun Lab @keun_lab]

Pleased to announce our latest #exposome paper as part of the #ATHLETEproject, in which we define a metabolome signature of diet quality in children linked to metabolic health. Congrats to @AlexandrosSISK1 & @ChatziLab https://t.co/ixaeuzyz9Y

[Surgery and Cancer @ImperialSandC]

An international research team, including @hectorkeun and @AlexandrosSISK1 from S&C, has identified metabolic ‘signatures’ in urine that can determine the quality of diets in children across Europe and predict their metabolic health. https://t.co/scsZCZ0N7v

[Keun Lab @keun_lab]

Very pleased to have contributed to this great paper from @auner_lab_ICL on stress resolution in multiple myeloma cells recovering from proteasome inhibition. Follow thread to find out out more 👇

[Holger W. Auner @auner_lab_CH]

How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵https://t.co/YxlYj7dP22

[Holger W. Auner @auner_lab_CH]

How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵https://t.co/YxlYj7dP22

[Eric Topol @EricTopol]

Distinguishing between vaccine efficacy and effectivenesss, looking at relative risk reduction (RRR), absolute risk reduction (ARR) and numbers needed to vaccinate (NNV) https://t.co/XlAYMgt1RB @LancetMicrobe by @ElsTorreele @IIPP_UCL and colleagues

[Ali Salehi-Reyhani @scientwist]

Another PhD that'll be formally advertised soon - this time through @STRATiGRAD Proj w/ Prof Iain McNeish @ImperialSandC & @AstraZeneca > biomarker discovery & instrument development for ovarian cancer. Interested or know anyone that might? Get in touch. RTs appreciated!

[Hector Keun @hectorkeun]

A big moment for me - 20 years ago today I started at @imperialcollege ! It has been a lot of fun, so lucky to have worked with so many brilliant and supportive colleagues. Thank you to all @keun_lab past and present👏you are amazing (And of course the best is yet to come... !)

[Science and Innovation at Cancer Research UK @CRUKresearch]

Recently published in @BrJCancer:

Pre-clinical research demonstrates lactic acidosis in cancer induces Akt inhibitor resistance. Interfering with lactic acid uptake reversed resistance to the Akt inhibitor, uprosertib.

@keun_lab @imperialcollege

https://t.co/3RIALNgOSW

[Keun Lab @keun_lab]

Our latest paper in which we show that lactic acidosis protects cancer cells from cell death induced by the pan-Akt inhibitor uprosertib, and how the effect can be reversed by metabolic inhibitors #cancermetabolism #tumormicroenvironment #drugresistance

https://t.co/X8wlBUseZM

[Keun Lab @keun_lab]

@madrozdz @jimiflanUK @edcurryphd @hectorkeun @tobias_warnecke @dagams @VasyaKusmartsev Our pleasure, congratulations on your award!

[neuro.social.self @neurosocialself]

Japan: Intercellular signal transduction during the assembly of slime mould cells • cAMP-sensitive fluorescent probes • signal is transmitted as a spiral wave within the group • amazing • via @kotapub https://t.co/CnKHtDN8yU

[Keun Lab @keun_lab]

Our latest paper where we studied which microRNAs can be measured stably over time in serum, a factor in making them good biomarker candidates. What we found was a surprising link to maternally imprinted genes
#geneimprinting #microRNAs #biomarkers

https://t.co/gd6aLRkSE9

[3D Models of Health and Disease @3dmodelsucl]

@JudithPape3 passed her viva! Congrats to this successful researcher!

[Keun Lab @keun_lab]

Congratulations to past @keun_lab member @JudithPape3 for passing her PhD viva! @3dmodelsucl #PhD #congratulations

[Lyssiotis Lab @LyssiotisLab]

(1/4) Check out our latest work on GOT1 metabolism in pancreatic cancer #Preprint #OpenAccess @biorxivpreprint!

[Lovorka Stojic @stojic_lovorka]

Check out our latest preprint on @biorxivpreprint on the role of #lncRNAs in cell division.https://t.co/qvvJM7jWfn …
Great collaboration with Aaron Lun, @MascalchiP @ChristinaErnst_ @Alexis_Barr @BakalLabICR @MarioniLab Duncan Odom & @fanni_gergely