This week, the market will be very volatile due to the on going Palestine Israel conflict. Gold will definitely go up, other mentals too will follow suit.
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Paracetamol and NSAIDs (Non-Steroidal Anti-Inflammatory Drugs e.g ibuprofen, diclofenac, piroxicam, naproxen, etc) are not the same.
Let me explain:
The main difference between paracetamol and NSAIDs is, paracetamol doesn’t have an anti-inflammatory activity.
Also, paracetamol doesn’t work by blocking the cyclooxygenase enzymes (cox-1 and cox-2) as such it doesn’t predispose one to ulcer or cause ulcers.
Lets break it down:
Yes, paracetamol is used to handle pain just like NSAIDs.
Yes, paracetamol is also used to handle fever, it’s also used to handle ache, but that doesn’t make it an NSAID.
NSAIDs (e.g ibuprofen) work by blocking enzymes known as cyclooxygenases: cyclooxygenase 1 and cyclo-oxygenase 2 (cox-1 and cox-2 respectively).
What does this enzymes do?
Cox-1 is the good guy, it’s found in most of the tissues in the body and it plays house-keeping functions. It helps protect the stomach from the digestive juices, it also helps in maintaining the normal lining of the stomach and intestines, amongst many other things.
Cox-2 on the other hand is the black sheep of the family, you only see it where there is trouble, where there is violence. If there is injury here, that’s where you will see it, it will rush there and cause even more pain.
Since you only see cox-2 where there is trouble, and when it gets there, it will mobilize more thugs to cause problems, it’s therefore known as the “inducible form”.
Why is it regarded as the inducible form?
Because just like I mentioned earlier, it’s expressed in response to inflammatory and other physiologic stimuli. The cox-2 is involved in the production of those chemicals that mediate pain and support the inflammatory process.
So NSAIDs (e.g diclofenac) work by blocking these two enzymes: cox-1 and cox-2. But that’s also where we have problem. Why?
Because even cox-1 wey no get wahala, cox-1 wey dey try protect stomach and the intestines, cox-1 wey dey mind em business dey also collect.
Once cox-1 is blocked there is nothing there to really protect the stomach from digestive juices, and if the blocking continues over a long period of time that’s when someone can come down with ulcer. That’s why you hear NSAIDs can cause ulcers.
This problem lead people to develop selective NSAIDs that only targets the black sheep of the family (cox-2) but that’s a story for another day.
Coming to our main topic which is, “paracetamol and NSAIDs are not the same”
Now, we have discussed how NSAIDs work: they block both cox-1 and cox-2, but paracetamol doesn’t work in that way, it doesn’t block cox-1 or cox-2. That’s why paracetamol is not anti-inflammatory meaning: you can not use paracetamol to handle inflammation.
Also, the fact paracetamol doesn’t touch the cyclooxygenase enzymes (cox-1 to be specific), that’s why paracetamol doesn’t cause ulcers.
That’s why it’s gentle on the stomach.
That’s why you can take it with or without food. But you can’t try that with NSAIDs.
You must eat before taking NSAIDs. MUST!
Before you take ibuprofen, eat.
Before you take diclofenac, eat.
Before you take Felvin (piroxicam), eat.
Before you take naproxen, eat.
You’re not to take NSAIDs on at empty stomach, but you can take paracetamol on an empty stomach.
We now come to the end of our today’s lecture on “why paracetamol is not same as NSAIDs” and “why you can take paracetamol on an empty stomach but you must eat before you take NSAIDs”.
Thank you. ☺️😉
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Right now is best time to start making money from Forex Trading.
Forex is world top business platform in which 7T Dollar trade daily.
But only 5-10% people are making money from trading because they learn right.
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