Kline Lab

Kline Lab @UChicagoHemOnc; focusing on overcoming immune evasion pathways in blood cancers and improving the effectiveness of cellular therapy in lymphoma

[Kline Lab @KlineLabUChi]

Very excited to share our lab's work is now out in print @JCO_ASCO! All-star lab member Alan Cooper and others develop a CD5 gene signature (CD5sig) that shows a selective EFS+OS benefit for CD5sig+ DLBCLs treated with R-CHOP+ibrutinib in PHOENIX trial...
https://t.co/g1FAyxJWkV

[UChicagoCancerCenter @UCCancerCenter]

Today at #ASH24, @AlexandraRojek presented excellent study demonstrating how PI3Kγ/δ inhibitors can delay terminal CAR T cell differentiation, an innovative approach to enhance the efficacy of CAR T cell therapy.
@KlineLabUChi @UChicagoHemOnc @UChicagoLeuk

[Kline Lab @KlineLabUChi]

We’re excited to see outstanding science talks at the Jonas Center for Cellular Therapy Symposium today @UChicagoHemOnc and updates on our lab’s work shared by Dr. Kline!

[UChicagoCancerCenter @UCCancerCenter]

Justin Kline, MD chairs an oral abstract session -"Hematologic Malignancies-Lymphoma and Chronic Lymphocytic Leukemia" and Peter A. Riedell, MD discusses 3 abstracts in the same session.
@KlineLabUChi @UCCancerCenter @UChicagoCCB

[UChicagoCancerCenter @UCCancerCenter]

🌟Exciting news alert! Scott Oakes, MD has been named Vice Dean for Clinical Science Research of @UChicagoBSD & @UChiPritzker. His expertise and leadership will undoubtedly elevate research efforts to new heights. Join us in congratulating him on this well-deserved appointment!🎉

[Klebanoff_Lab @KlebanoffLab]

🚨Fantastic pair of papers in @Nature today from @EvanWeberPhD, @MackallLab and the Darcy lab @PeterMacCC on enforcing stem-like molecular programs in therapeutic T cells through overexpression of #FOXO1! 👇
https://t.co/9chDibF8Ai. @ChildrensPhila @StanfordCancer @parkerici

[UChicagoCancerCenter @UCCancerCenter]

Sidney Wang, grad student in Kline’s lab presents excellent poster at #AACR24 showing PRDM1 as a potential therapeutic target to enhance CAR-T therapy efficiency in large B-cell lymphoma.
#NationalCancerPlan #Every1HasARole @UCCancerCenter @UChicagoHemOnc
@theNCI @KlineLabUChi

[UChicagoCancerCenter @UCCancerCenter]

Joanna Chorazeczewski, graduate student from Kline’s lab presents excellent data on the mechanisms underlying the bystander killing by CAR Tcells. @UCCancerCenter @UChicagoCCB @UChicagoCOI

[UChicagoCancerCenter @UCCancerCenter]

Functional, expanded T cells may be responsible for #ICB success in classical Hodgkin lymphoma according to new research in @CIR_AACR from @KlineLabUChi and team. @UChicagoMed @UChicagoHemOnc #cHL #lymsm
https://t.co/s8H7l7ZcT9

[UChicagoCancerCenter @UCCancerCenter]

Huge congratulations to Pete Savage, PhD, Associate Professor of Pathology on his new appointment as chair of the Committee on Immunology (@UChicagoCOI). His leadership in COI and @UCCancerCenter is invaluable. #CancerResearch #Immunology 🧬🔬
https://t.co/afZCbeIW4X

[Kline Lab @KlineLabUChi]

With #AACR24 approaching, make sure to check out fantastic posters presented by 2 of our lab members on CAR T cell therapy!

https://t.co/oJiI5yDFyE presented by grad student @jchorazeczewski

https://t.co/hmjacCo4Ev presented by grad student Sidney Wang!

@UChicagoHemOnc

[Oncology Learning Network @OncLearnNetwork]

Here, Justin Kline, MD, @UCCancerCenter, @UChicagoMed, discussed a novel CD5 gene expression signature (CD5sig) that is a useful biomarker to identify #DLBCL subtypes vulnerable to #BTK inhibitor therapies. Learn more: https://t.co/PJNcsQHfBa #MedTwitter #Oncology #OncologyNews

[University of Chicago Hematology/Oncology @UChicagoHemOnc]

Congratulations to Dr. Kline & team on a great new article on single-cell phenotyping of the classic Hodgkin lymphoma (cHL) environment, with results that shed new light on the nature of T cells: https://t.co/EeI7FjMfmm
@AACR @UChicagoMed @UCCancerCenter
#lymphoma #Tcells

[Jonathan Friedberg @DrJFriedberg]

CD5 represents an easy and exportable biomarker, appears to be a surrogate for molecular subtypes in DLBCL, and should be characterized in ongoing and future studies of targeted agents that perturb BCR signaling. @JCO_ASCO https://t.co/kLwG0UJz7C

[Kline Lab @KlineLabUChi]

@gvencut1 @SoniSmithMD @jovianyu @UChicagoHemOnc @UCCancerCenter

[Kline Lab @KlineLabUChi]

Very excited to share our lab's work is now out in print @JCO_ASCO! All-star lab member Alan Cooper and others develop a CD5 gene signature (CD5sig) that shows a selective EFS+OS benefit for CD5sig+ DLBCLs treated with R-CHOP+ibrutinib in PHOENIX trial...
https://t.co/g1FAyxJWkV

[Kline Lab @KlineLabUChi]

Thus, CD5sig is a useful biomarker to identify DLBCLs vulnerable to BTKi-based therapies and complements current biomarker approaches by identifying DLBCLs with genetic and non-genetic bases for BTKi sensitivity

[UChicagoCancerCenter @UCCancerCenter]

🚀 Join us in congratulating our new Program Co-Leaders and stay tuned for the groundbreaking work they lead at @UCCancerCenter✨
#CancerResearch #ExpertLeadership #InnovativeCollaboration #MolecularMechanisms #Pathology #Genetics #UCCCCLeaders #Healthcare #MedicalResearch

[Ajay Major, MD, MBA @majorajay]

New paper out of the @KlineLabUChi @UChicagoMed about function of T cells in the Hodgkin tumor microenvironment and implications on mechanism of PD1/PDL1 checkpoint blockade. #lymsm cc @SoniSmithMD @jovianyu @gvencut1 https://t.co/IFZ6SXOPbA

[Kline Lab @KlineLabUChi]

@UChicagoHemOnc @UCCancerCenter

[Kline Lab @KlineLabUChi]

We're excited to make our lab page debut sharing some exciting new work from lab members Xiufen Chen and lab alum @jovianyu in @CIR_AACR evaluating phenotypic and functional T cell states in cHL samples along with T cell clonality at the single cell level!
https://t.co/joFLvdKs6w