@icmteaching I’m interested in reading your latest paper published in Anaesthesia, but unfortunately my institution does not have full text access. Would it be possible to share a .pdf?
In kids, there’s much less in the way of hard 24 h limits (and a lot of different numbers floating around) so we most commonly think in terms of infusion rates. For ropivacaine, 0.3-0.5 mg/kg/h is generally well-tolerated in most kids…with adjustments for the very young: for 0-4 months use 0.2 mg/kg/h; for 5-12 months use 0.3 mg/kg/h. @mfettiplace , @BrittaniBungart and team did a really great paper on this recently—worth a read:
https://t.co/eRj76QxdTW
This is a great question—we often think about single doses but not cumulative. The drug label in the U.S. says “Experience to date indicates that a cumulative dose of up to 770 mg Naropin administered over 24 hours is well tolerated in
adults when used for postoperative pain management”. That’s what our team uses as a limit. So that means catheters infusing 0.2% can run a total of 16 ml/hr (our limit for 2 catheters is 8+8 for this reason). 16 ml x 2 mg/ml x 24 hr = 768 mg. That’s for adults…(1/2)
@mfettiplace@lipidguy@ASRA_Society@DaraEsra@ESRA_Society@BlockIt_Hot_Pod@EMARIANOMD@James_Kim_MD@RegionalAnaesUK
@amit_pawa@jeffgadsden Question re your #BILIH catheter episode. What’s your max daily dose of ropivacaine in continuous blocks? My old institution used max 0,6 mg/kg/hr | 14,4 mg/kg/day. But I’m struggling to find any good evidence for this or any other dose for that matter.
@DrNavSidhu@iceman_ex@ANZCA@AUDiabetesSoc Good points, perhaps the other systemic effects persist past 12 weeks. I’m afraid we’ll never get any robust data on the effect of (dis)continuing GLP-1 agonist on aspiration given the rarity of the event.
@amit_pawa@MJTB1987@Assoc_Anaes@ASALifeline The half life of semaglutide/Ozempic is 1 week, such that stopping it 1 week preop doesn’t make any pharmacokinetic sense. 3-4(-5) half lives would be better. But then there’s the problem of glycaemic control after discontinuation.
@AirwayMxAcademy @GongGasGirl You might be right, USA has to wait until 2026 but in Europe it should me off patent. I’m based in Norway, we only have Bridion though.
@pr8sport ik begeleid morgen een familielid tot aan de security op Schiphol, kunt u mij vertellen of er boarding passes gecontroleerd worden aan het begin van de rij (zodat ik evt niet mee kan?)