Dr. CY

Doctor & Scientist Duo | Evidence-based personalized medicine and longevity science 🩺🔬 | Views are my own

[Dr. CY @klyoomdphd]

But how much of this is directly caused by the drugs themselves, and how much might be explained by changes in metabolism, adiposity, or other factors?
https://t.co/7zIpT7CBDd

[Dr. CY @klyoomdphd]

We all know the new generation of weight-loss drugs can rapidly move the number on the scale. But what if some of their most important effects have little to do with fat loss?

[Dr. CY @klyoomdphd]

The findings add to a growing body of research suggesting that GLP-1/GIP-based therapies may have effects that reach far beyond weight loss.

[Dr. CY @klyoomdphd]

The findings raise an important question: could GLP-1 signaling reproduce some of the molecular effects associated with fasting, even without calorie restriction itself? https://t.co/Owx7Fg7QFZ

[Dr. CY @klyoomdphd]

For decades, one of the central ideas in longevity science has been calorie restriction: eating less to activate biological pathways associated with healthier aging. But what if some of those same pathways could be engaged without prolonged hunger?

[Dr. CY @klyoomdphd]

A striking new 2026 study published in Nature offers an intriguing clue. In aged mice, semaglutide, a GLP-1 receptor agonist, was associated with changes in biological pathways linked to metabolism, cellular stress, and aging.

[Dr. CY @klyoomdphd]

Discover what these clocks actually measure, where their limitations lie, and the real-world, measurable metric you should be tracking if you want to know whether you are truly improving your healthspan, not simply changing a number on a test. https://t.co/bfpqw8cc4l

[Dr. CY @klyoomdphd]

We are obsessed with turning back the clock. People are spending thousands of dollars on epigenetic tests that claim to show they have reversed their biological age.

[Dr. CY @klyoomdphd]

But a crucial new paper from leading longevity researchers at Harvard highlights a fundamental problem with how we think about these measurements.
What if your molecular “clock” says you are 35, while your actual functional capacity looks more like 60?

[Nick Norwitz MD PhD @nicknorwitz]

Did AI Just Build an Exercise Pill?

1/4) A biotech company just used AI to design the first “pill built from the chemistry of exercise.” But let’s start where the biology starts: with nature.

In 2022, Stanford researchers discovered a molecule called Lac-Phe that spikes during exercise in mice, racehorses, and humans, particularly during high-intensity activities like sprinting.

[Dr. CY @klyoomdphd]

You may be taking melatonin to improve your sleep, but a large 2026 study reveals long-term use of this popular supplement is linked to a 90% increased risk of heart failure. https://t.co/8g10Nj8E5R

[Dr. CY @klyoomdphd]

A new Nature study suggests that chronic stress can suppress the formation of new brain cells, and how we can flip the switch back to neurogenesis. https://t.co/PlrzBKNe7U

[Nick Norwitz MD PhD @nicknorwitz]

A common misperception about artificial sweeteners is that they acutely spike blood sugar and insulin.

The truth is more insidious and more problematic.

If you have a diet soda or artificial sweeteners, your blood sugar and insulin don’t rise acutely.

However, there are data, including human data, showing that shifts to the microbiome can cause insulin resistance and increased insulin levels over time.

A landmark trial published in Nature found that when artificial sweetener-naive humans were given artificial sweeteners, just over half developed insulin resistance within one week.

Importantly, transplanting their microbiomes before and after artificial sweetener exposure could transfer the insulin resistance phenotype to animals, proving the mechanism was mediated by the microbiome.

I didn’t say a Diet Coke is worse than a Coke.

But just because a diet soda doesn’t spike your blood sugar over the short term does not mean it’s not doing any damage.

👉I’ll be doing a masterclass breakdown on all this & a self-experiment related to sweeteners and the Vagus Nerve. What more do you want to know?

[Dr. CY @klyoomdphd]

We can track our macros perfectly, but if we’re missing these three microscopic molecules, we may be quietly accelerating aspects of biological aging. https://t.co/lA1vaf1dH4

[Michael Snyder, PhD @SnyderShot]

Is US losing it science dominance? We need to keep recruiting top talent. https://t.co/sRIhKrl1O1

[Dr. CY @klyoomdphd]

Why Stanford is abandoning generic gene therapies to test a revolutionary CRISPR "True Correction" method on children, and what it means for your health. https://t.co/56n4bXYTiM

[Dr. CY @klyoomdphd]

A 2026 clinical trial just showed that when it comes to reversing biological aging, what you eat matters just as much as how much you lose. https://t.co/MHwaDbhmVZ

[Dr. CY @klyoomdphd]

Why your doctor is burning out, and how a massive 2026 Medicare reform bill could save the independent clinics that focus on your healthcare. https://t.co/y9aOCWJ2Ex

[Dr. CY @klyoomdphd]

Why the pesticides in your food are driving cognitive decline, and the specific gut bacteria acting as your brain's first line of defense. https://t.co/VrZvrrTJt6