Kookjoo Kim

🌊

[Julius Wenckstern @j_wenckstern]

1/
What could we discover if we had a binder for every protein in the human proteome?

We are excited to introduce the Bindome, an open and free resource of over 300,000 designed protein binder candidates against over 8,000 human target proteins.

🧵

[Membrane Protein PDB @MemProtPDB]

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene | bioRxiv

https://t.co/WESlpz97g7

[bioRxiv Biophysics @biorxiv_biophys]

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene https://t.co/HlrFSOsHhV #biorxiv_biophys

[Mark Lewis, MD, FASCO @marklewismd]

Incredible tribute to phospholipids

[Jeremiah Johnson 🌐 @JeremiahDJohns]

Common Wisconsin W

[Structura Biotechnology @structurabio]

1/ #CryoSPARC v4.4 is here! 🚀
Updates include tools to streamline repeat #cryoEM processing, reference based motion correction, orientation diagnostics, symmetry tools, improved 3DFlex, caching, data cleanup and more!
https://t.co/M3mLGtFPIq

[ChimeraX (bsky: chimerax.ucsf.edu) @UCSFChimeraX]

You can predict protein structures with ESMFold from ChimeraX (November 9 daily build or newer). The image shows farnesyltransferase subunit alpha predicted in blue compared to experiment in white. Details here https://t.co/MPe2DpMC9j

[Martin Pacesa @MartinPacesa]

Wanted to share 2 cover designs I made for our recently published paper on Cas9 conformational dynamics. They were really fun to do!

https://t.co/lN52efEBj5

[とりさん @biochem_fan]

GeForce 4080/4090 have been announced. These GPUs are getting less and less suitable for SPA data processing, at least for RELION.

Although the cost per FP32 TFLOPS (NB: Tensor Cores are useless for RELION) is getting cheaper, memory and bandwidth per TFLOPS is getting smaller.

[Lucrezia Catapano @lulu_catapano]

Hi guys! I made 2 new coot tutorials covering the coot 1 graphics 😃.
I will show you:
1. How to make a figure using the GUI
https://t.co/aexDR02TYs
2. How to make a figure by scripting in Python using coot as a module
https://t.co/QKmEuQjzPw

[Laura Luebbert, PhD @NeuroLuebbert]

gget alphafold: Predict the 3D structure of a protein from its amino acid sequence using @DeepMind’s AlphaFold v2.0 from a Python or command-line environment in 3 lines of code. Runs on any laptop and requires only ~4 GB of disk space. Simply ‘pip install gget’ and:

[Structure @Structure_CP]

The lab of Andrew Marks @Columbia solved the cryo-EM structure of ARM210-bound type 1 ryanodine receptor that reveals a second binding site for ATP

https://t.co/c1ZxWoV8Li

[EMDB - EMPIAR @EBI @EMDB_EMPIAR]

Released @EMDB_EMPIAR & @PDBeurope, & published @NatureSMB, the stunning 2.7 Å #SingleParticle #CryoEM #Composite structure of Class 1 #Human #Erythrocyte #Ankyrin-1 complex, uncovering the mechanism of ankyrin-mediated #Membrane #Protein clustering
1/3

[EMDB - EMPIAR @EBI @EMDB_EMPIAR]

Study by Francesca Vallese, @kookjookeem, Laura Yen, Jake Johnston, @alexjamesnoble, Tito Calì & @OliBClarke from @ColumbiaMed, @Columbia, @SEMC_NYSBC & University of Padua

Paper: https://t.co/hbMM6PQPv7
2/3

[Francesca Vallese @Frances84469032]

Finally out in NSMB! Ankyrin-1 complex…this is just the beginning.