Scott Kulm

PhD student in @ElementoLab at @WeillCornell, trying to improve genetic disease prediction. Marathon manic, busy baker, cat caretaker, hopeful human.

[Olivier Elemento @ElementoLab]

NIH capping indirect costs at 15% sounds great—until you realize it guts the infrastructure that makes research possible. Labs don’t run on goodwill alone. This is a short-sighted move that will slow innovation and hurt future discoveries. #FundScience #NIH

[Keith @keithdunn]

Jasmin Paris @JasminKParis finished loop five of the #BM100 in 59:58:21.

[Andrew Marderstein @amarderstein]

Excited to share a fun collaboration w/ @sbmontgom & Ana Cvejic!

Using the largest single-cell dataset of fetal hematopoiesis in Down Syndrome to date, we asked:

Why is trisomy 21 associated w/ both elevated leukemia risk + red blood cell abnormalities?
https://t.co/yvhCnyO5wv

[Allelica @Allelica_PRS]

Discovery how polygenic risk scores (PRS) can help superpower clinical trials in the latest Allelica blog post: https://t.co/vgFUEJH0ly

#PRS #polygenic #clinicaltrial #drugdevelopment #pharmaceuticals

[Jin Jin @Jin_10ustc]

New preprint out on ME-Bayes SL, a novel algorithm for multi-ancestry polygenic prediction @PRSdiversity. A wonderful collaboration with @23andMe @nilanjan10c @genandgenes @AndrewHaoyu @JingningZhang35 @RuzhangZhao and many others! https://t.co/2Cs1Ivdg9e

[Keith @keithdunn]

Aurelian Sanchez completed loop five and has finished the 2023 Barkley Marathons in 58:23:12. A bit of a challenge near the end - a day hiker removed one of the books, believing the race was over. #BM100

[National Human Genome Research Institute @genome_gov]

When you’re trying to advance genomic medicine to help all populations, but you can only find data that come from people with European ancestry.

[Todd Lencz @ToddLencz]

NEW: Excited to share this longform essay on polygenic embryo screening (PES) co-authored with @ShaiCarmi — Written for the general audience, this piece also serves as a review of the main issues surrounding PES.
Comments are open!

https://t.co/WBkK2QoeOw

[Andrew Marderstein @amarderstein]

pretty cool study+NYT article but writing:

“true” look-alikes shared significantly more of their genes
or
"people who look more alike have more genes in common"

is nonsense and shows that the public still struggles with their understanding of genetics

https://t.co/TyVeXCjARe

[Bjarni Vilhjalmsson @bvilhjal]

It turns out that accounting for age-of-onset information using (efficient) Cox-based GWAS methods may not always result in increased power to detect genetic variants in practice.

[Scott Kulm @KulmScott]

I have heard about this paper for years and can tell you the amount of work, sophistication of the experimental techniques and vastness of the results that went into this paper are mind-blowing - an amazing scientific achievement!

[GWAS_lit @GWAS_lit]

UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits https://t.co/S6MzWET7Fr

[Andrew Marderstein @amarderstein]

Graduation, 11 months after graduation. 👨‍🎓 👨‍🎓 @KulmScott @WeillCornell

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

During #LabWeek2022 we honor @WCMEnglanderIPM member labs, including Director Dr. Olivier Elemento's @ElementoLab revolutionizing healthcare by developing innovative approaches to better predict, diagnose, treat and prevent disease! #PrecisionMedicine

https://t.co/iXxK5VxqiV

[Angewandte Chemie @angew_chem]

Ultrasound-Responsive Aqueous Two-Phase Microcapsules for On-Demand Drug Release @SiaBME https://t.co/bqDkcoY6MH

[Andrew Marderstein @amarderstein]

COVID-19 has disrupted scientific workplaces and the way in which we work.

As a result, what does work-life balance look like now?

Join us @GeneticsSociety for tomorrow's discussion! (8 am PT/11 am ET)

Link & details below 👇

https://t.co/4ZMsOtPRlz

[Scott Kulm @KulmScott]

Thank you so much to @ElementoLab for helping with this project.

There are so many details that I couldn't fit into a tweet-orial so please check on the preprint, or message me.

[Scott Kulm @KulmScott]

"All models are wrong but some are useful"

Is the model you're using to assess the accuracy of a polygenic risk score the most useful? We investigated just that questions in this preprint: https://t.co/Zwua4ic74E

[Scott Kulm @KulmScott]

There are of course many limitations (portability!), and many interesting details on how small changes to our models might reduce assumptions. The key takeaway:

the model type you're using does matter, so try to see if you can make it more useful