Kodai Kume

RIRBM Hiroshima University
Neurogenetics / Neurology
The views expressed on this account are my own

[Kodai Kume @kumek18]

Our new paper is out!
We identified an AGG repeat expansion in BIN1 as a variant associated with multiple system atrophy.
Huge thanks to all collaborators and to the patients and families who made this work possible.

https://t.co/v5O2fsnRxd

#MSA #neurogenetics

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Somatic mosaicism in the brain: linking development, ageing and neurodegeneration | Nature Reviews Neurology https://t.co/aFPI0RrIxt

[羊土社 実験医学 @Yodosha_EM]

初めて学会に参加する学生さんへ🐏
よく出る遺伝子を事前にインプットしておくと、発表に集中できて理解度もアップします🙂
『論文に出る遺伝子 デルジーン300』を行きの新幹線でパラっと見ておくのがおすすめです📗🚅
https://t.co/M2B8IckJls
必要な方に届くよう拡散いただけましたら幸いです

[Kodai Kume @kumek18]

科研費申請完了

[Kodai Kume @kumek18]

無作為抽出により不採択。
二回目、お願いします！

[Kodai Kume @kumek18]

横浜のジャズを楽しんでいる

[Kodai Kume @kumek18]

分割キーボードのおかげで、肩こりが改善した！

[Kodai Kume @kumek18]

助成金申請書2つ書き上げた

[Kodai Kume @kumek18]

基盤Bは不採択、萌芽は一次審査は通ったよう

[ライブドアニュース @livedoornews]

【気になる】讃岐うどんを食べて育ったウニ、調理実習で刺身に 「なめらかでおいしい」
https://t.co/fGnZZfaVHr

食用にはむかないムラサキウ二に、廃棄になったうどんを与えて育てたそう。うどんをエサにしているため、一般的なウニと比べて白っぽいといい、なめらかでおいしいという。

[ライブドアニュース @livedoornews]

【気になる】酢飯の代わりに“うどん“使用、うどん恵方巻を限定販売へ 香川
https://t.co/IH4fWoyquQ

高松道・津田の松原サービスエリアを運営する穴吹エンタープライズが2月3日に販売。酢飯の代わりにうどんを使って海苔で巻いたもので、うどんすきを食べているような味に仕上がっているという。

[Shuhei Ohno @ohnolab]

参加登録100名突破🎉
JuliaLang Japan 2025 は12月13日(土) 東京科学大学 大岡山キャンパスにて対面・オンラインハイブリッド形式で開催されます！奮ってご参加ください！
#Julia言語 #JuliaLang #JuliaLangJa #JuliaLangJa2025
https://t.co/kXlci8b6RD

[Neuron @NeuroCellPress]

Online now: Resolving the mysteries of brain clearance and immune surveillance https://t.co/R8suLN6eNv

[The Nobel Prize @NobelPrize]

Mary Brunkow and Fred Ramsdell – who have been awarded the 2025 Nobel Prize in Physiology or Medicine – gained decisive insights into how autoimmune diseases arise.

Brunkow and Ramsdell made a key discovery in 2001, when they presented the explanation for why a specific mouse strain (named scurfy) was particularly vulnerable to autoimmune diseases.

The medicine laureates had discovered that the mice have a mutation in a gene that they named Foxp3. They also showed that mutations in the human equivalent of this gene cause a serious autoimmune disease, IPEX.

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[The Nobel Prize @NobelPrize]

Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body.

The Nobel Prize laureates identified the immune system’s security guards, regulatory T cells, thus laying the foundation for a new field of research. The discoveries have also led to the development of potential medical treatments that are now being evaluated in clinical trials.

The hope is to be able to treat or cure autoimmune diseases, provide more effective cancer treatments and prevent serious complications after stem cell transplants.

#NobelPrize

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

[Kodai Kume @kumek18]

なんとか間に合って申請した

[Kodai Kume @kumek18]

Our paper is published!
We identified novel variants in ELOVL4, ELOVL5, and GRM1.

https://t.co/RMRZ5v7b87

[Kodai Kume @kumek18]

Our preprint is out!
We have identified AGG repeat expansion in BIN1 as a causative variant for multiple system atrophy (MSA) and discovered that the BIN1 protein aggregates in the brains of individuals with MSA.

https://t.co/8HYg0he9Ye

[Ｊｕｎ Ｙａｓｕｄａ @jyasuda1]

アルツハイマー病の脳に沈着するtau fiblileを震盪以外の力を加えずに溶解させるD-peptideの機構を探ったとする論文。Nature。

https://t.co/lzNsfsbLt5