Had a great 4th of July in 🇬🇧@BritishDermDocs at the 104th Annual Meeting of the British Association of Dermatologists. Also enjoyed visiting Leeds Hospital @NHSEngland to give grand rounds on chronic itch from atopic dermatitis to prurigo & beyond #BAD2024#dermtwitter
The biggest need in #itch clinical management is for safe, effective therapeutics for neuropathic pruritus. Here in @jacionline together with Xinzhong Dong @HHMINEWS & @AnushaKambala we reset our paradigm of neuropathic itch https://t.co/TIIyCmp0fY @itchdoctor thx for the invite!
What a huge honor to present at the @AADskin Late Breaker Session to provide the first glimpse of data from the Olympia 2 phase 3 trial of nemolizumab monotherapy in Prurigo Nodularis! There’s a revolution going on in PN, #Prurigo in #Primetime! #AAD23LateBreaker#dermtwitter
Amazing meeting at the @SkinOfColor Society’s Scientific Symposium. Just ran into our fearless @AADskin president-elect @SeemalRDesaiMD. Always making deals & working the phones! #dermtwitter
Jak inhibitors are emerging in so many dermatology diseases & gaining approvals w/cross immune-axis activity (Th1,2,17,22). But there’s a lot to think about at the bedside with pts. Here’s our approach to risk stratification & lab monitoring https://t.co/KCw0mRml6R #dermtwitter
The findings highlight that clinicians should be aware of neuroimmune-biased endotypes in chronic itch pts. We had similar findings in chronic pruritus of unknown origin https://t.co/eCoEABKSlO. Another reason I make a habit to ask itch patients about hx of disc disease & atopy.
Our study on the circulating plasma proteome of prurigo nodularis (PN) patients just dropped https://t.co/wA2g0CTSoK in @JAADjournals. Led by @vparthas, we show dz heterogeneity and endotypes in line w/the variable response to tx we see clinically @HopkinsMedicine#dermtwitter
We also identify fibroblast-neuronal axes for chronic itch in PN with interactions between WNT5A-MCAM and periostin-ITGAV. Calcium signaling and knockout models are ongoing with our great collaborator Xinzhong Dong @HHMINEWS
My lab is thrilled to share our latest work led by @JaPately which features the first single-cell RNA sequencing study on prurigo nodularis https://t.co/EmT6heZRtt. We had several findings that change the way I think about the disease #dermtwitter
Happy to share our study by @junedeng10 & team on what’s unique in prurigo nodularis compared to atopic dermatitis - https://t.co/lEkVDe25jV
⬆️ TGF-beta signaling and dermal NGF
⬆️ OSM - in line with trial results showing failure of OSM inhibitors in AD but promising data in PN
Episode 275 is up on #TheHealthySkinShow, and I'm a fan of this one! If you suffer from #eczema or (like me) have had a little one with SUPER itchy eczema, it will make you think twice before you tell someone to "just stop itching!"
https://t.co/teroSaPoso
It’s that time of year again! Every year I am so impressed with the incredible talent of dermatology residency & 2+2 applicants. Excited to share my journey as we make our pitch to showcase our program’s culture and leadership in dermatology @HopkinsMedicine#dermtwitter