Guo Lab (Sheffield)

The Guo Lab aims to understand the basic cell stress mechanisms associated with protein post-translational modifications in Health and Disease

[Guo Lab (Sheffield) @lab_guo]

Exciting news out of Professor David Chan’s lab! Their latest paper shares findings that are beautifully consistent with our previous work on FIS1-mediated mitophagy.

https://t.co/akgFqRYXi6

[Guo Lab (Sheffield) @lab_guo]

For fun: 'Mature SUMO' https://t.co/sRE2waYzT7

[Guo Lab (Sheffield) @lab_guo]

"PINK1 SUMOylation regulates basal mitophagy" https://t.co/pcTOIkfyfF

[Guo Lab (Sheffield) @lab_guo]

To meet, learn and discuss: an exciting meeting for sure 😊
https://t.co/NQg6Itw6dz

[Guo Lab (Sheffield) @lab_guo]

https://t.co/PiPMI5AJWp
EMBO Workshop
SUMOylation: From discovery to translation

22 – 25 September 2025 | La Grande Motte, France

I am sure this will be a good one😊.

[Guo Lab (Sheffield) @lab_guo]

This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.

[Guo Lab (Sheffield) @lab_guo]

New Primary Research Publication from This Lab:
'SENP3-FIS1 axis promotes mitophagy and cell survival under hypoxia'
https://t.co/J4AAEcww4m

[Guo Lab (Sheffield) @lab_guo]

@MCB_Sheffield @ScienceShef @sheffielduni This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.

[Guo Lab (Sheffield) @lab_guo]

For the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.

[Guo Lab (Sheffield) @lab_guo]

@MCB_Sheffield @ScienceShef @sheffielduni In this paper, for the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.

[Guo Lab (Sheffield) @lab_guo]

https://t.co/UGA79eNRi4

[Guo Lab (Sheffield) @lab_guo]

'we propose a novel SUMOylation-dependent pathway where the SENP3-FIS1 axis promotes HIM, with TBC1D17 acting as a fine-tuning regulator.'

[Guo Lab (Sheffield) @lab_guo]

@ShengnanYuan

[Guo Lab (Sheffield) @lab_guo]

@BCiani Thank you! 👍

[Guo Lab (Sheffield) @lab_guo]

Happy to be part of the team 🥰
" ... C.G. first identified MFF as a SUMO substrate. . All authors contributed to editing the manuscript."
Another set of evidence highlighting SUMO's regulatory function in mitochondrial fission
https://t.co/zhpLR7Jgsl

[Guo Lab (Sheffield) @lab_guo]

SENP3 knockout mice exhibit embryonic lethality at day 8.5, characterised by a neural tube defect and abnormal cardiac asymmetry (left-sided).
https://t.co/VzUdo6D6mS

[Guo Lab (Sheffield) @lab_guo]

MiDs - MFF - DRP1 actions in mitochondrial fission

https://t.co/Ln2WwG1DT8

[Guo Lab (Sheffield) @lab_guo]

"Overall, base editor screening of PTM sites provides a powerful platform to dissect PTM function within signaling pathways."

https://t.co/3YOfAFTOR5

[Guo Lab (Sheffield) @lab_guo]

Collaboration between the mitochondria and the nuclei in protein making

https://t.co/B80Z8hl72R

[Guo Lab (Sheffield) @lab_guo]

"#1 out of 140 UK Universities"

[Guo Lab (Sheffield) @lab_guo]

The University of Sheffield Reviews by students
https://t.co/u2npq1BdmC