ManuelMuellerLab

Sir Henry Dale Fellow, King's College London. Interested in proteins and their post-translational modifications.

[ManuelMuellerLab @lab_mueller]

@stevenschem @Penn_CBIO @PennMedicine Congratulations Adam, i look forward to hearing about your lab's research.

[J. Am. Chem. Soc. @J_A_C_S]

Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society
@KingsCollegeLon
https://t.co/vhr8vqC4sw

[ManuelMuellerLab @lab_mueller]

@kclchemistry @KingsNMES Thanks Kenji for the write-up.

[ManuelMuellerLab @lab_mueller]

Congratulations co-1st authors @_TianzeZhang & Luis Guerra @kclchemistry and great collaboration with Iana @Beatfierz and Jon.

[ManuelMuellerLab @lab_mueller]

Thrilled to announce our group's latest paper in @J_A_C_S: Semisynthesis of Isomerized Histone H4 Reveals Robustness and Vulnerability of Chromatin toward Molecular Aging | Journal of the American Chemical Society https://t.co/DYm9lpbhTU

[ManuelMuellerLab @lab_mueller]

We chemically synthesized old histones containing an isoAspartate residue to measure the impact of aging on chromatin integrity. We found that chromatin is surprisingly tolerant of this particular form of wear-and-tear, although local perturbations were observed.

[The Wilson Group @AJWilsonGroup]

Check out this fully funded PhD studentship on peptidomimetics available in the Wilson group. https://t.co/VXiv1ftAok

[Nick Mitchell @mitchell_chem]

I have an AstraZeneca-funded PhD position available (4 years), based in my lab (School of Chemistry, University of Nottingham); start date Oct 2025!

Traceless Chemoenzymatic Peptide Synthesis

Application deadline: 6 Jan 2025. Get in touch!!!

https://t.co/Iox6KyotpK

[ManuelMuellerLab @lab_mueller]

@Jeannine__Hess Exciting joint PhD project availble with @Jeannine__Hess at the interface of biomedicinal chemistry and chemical biology through @The_MRC DTP. https://t.co/XafQaNICFw…

[Charlie McTernan @CharlieMcTernan]

Come and join my group @TheCrick - we have a PhD https://t.co/sgs0HAccNJ in metal-peptidic cages and high affinity binders, and will advertise a 3 year PDRA in December for a Chemical Biologist with synthetic and cell work experience. Email if interested, retweets appreciated!

[ManuelMuellerLab @lab_mueller]

@AJWilsonGroup Thanks very much :)

[J. Am. Chem. Soc. @J_A_C_S]

Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society @kclchemistry @KingsCollegeLon #Kinetic #Resolution #Epimeric #Proteins #Stereoselective #Chemical #Mutagenesis https://t.co/hkwpqimUvG

[ManuelMuellerLab @lab_mueller]

@NShahLab @J_A_C_S Thanks Neel!

[ManuelMuellerLab @lab_mueller]

Thrilled to highlight our work on chemoenzymatic protein modification, recently published in @J_A_C_S :
Kinetic Resolution of Epimeric Proteins Enables Stereoselective Chemical Mutagenesis | Journal of the American Chemical Society (https://t.co/IZ2sS6i4m6)

[ManuelMuellerLab @lab_mueller]

@JbaraM90 @J_A_C_S Thank you!

[ManuelMuellerLab @lab_mueller]

@Beatfierz @J_A_C_S Thanks Beat!

[ManuelMuellerLab @lab_mueller]

@J_A_C_S Great collaboration with @rli22 and @nott_lab

[ManuelMuellerLab @lab_mueller]

@J_A_C_S Led by PhD student Guljannat, we introduced a kinetic resolution step to dehydroalanine chemistry. By cleaving the D-amino acid-containing isomer with a D-peptidase, we combine the stereoselectivity of enzymes with the broad scope of chemo-selective Dha functionalisation.

[King's Chemistry @kclchemistry]

A new scholarship is available to next year's MRes Chemistry students - apply by 31 August.

The Mackenzie Family Scholarship established in the memory of Mr F.H. Mackenzie is a prestigious award covering a £22,000 stipend ⚗️

Find out more 🔗⬇️
https://t.co/RDSxMTOtiF

[Rebecca Buller @rebeccambuller]

Excited about engineering powerful biocatalysts? Check out the open PhD position in my group!

👉https://t.co/yvqlyrw2zl

Please spread the word!🇨🇭🏔️🧪🌿☀️

@NCCR_Catalysis @ZHAW

Photo: ZHAW Wädenswil / Frank Brüderli