Dose is key🗝️. Higher doses of AAV (1uL of 4 x 10^12 GC/mL) consistently induced ventriculomegaly and permissive tropism in neonates, while moderate doses (1uL of 1 x 10^12 GC/mL) didn't. Study led by Luke Liu, with co-authors Ania Noguera, Ryan Humphries, and Blake Zhou.
📃Preprint alert @biorxivpreprint . Does your 2026 involve ICV injections of AAVs 🧠? If so, this study led by Luke in the lab is for you. https://t.co/7W2fHyBcYs
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models - @StanfordRad https://t.co/BludN4qtBd
“We’re making a helmet people can wear that delivers ultrasound to the brain, and we plan to initiate clinical testing of this protocol in the next few months,” said Raag Airan.
With Knight Initiative support, his lab plans to test it on people soon.
🔗https://t.co/AyFXhn6rem
Congrats to the Seed Grant awardees! Projects include efforts to develop new tools for delivering drugs to the brain; study the role of neuropeptide molecules in pain & brain signaling; and probe the links between genetics, inflammation, & Alzheimer’s.
🔗https://t.co/sVLwgm1JAL
Today, we celebrate Ania Noguera's time in the lab. On her last day with us, we are so excited about her transition to @UCBerkeley - but will miss her expertise here! 🧠
Molecular Hallmarks of Hydrocephalus @ScienceTM is out today. Grateful to work under leadership of @andrewthale3@ScienceDame@KahleKristopher with other top-notch collaborators including @LabFame members Arjun Rajan and Blake Zhou! https://t.co/4FUcVXHrOR
Many thanks to the editors of @Nature_NPJ Biological Timing and Sleep for treating this important topic and for the collegial and scholarly reviewers who reviewed this article.
https://t.co/p6Pxxhp5Xa
How does the brain change during the day🌞🌛? Can this inform treatments?
Learn more in a new review from the lab 'Harnessing the #circadian nature of the choroid plexus and cerebrospinal fluid' npj Biological Timing & Sleep | #Nature@Nature_NPJ https://t.co/zUzpsR4WnA