Laboratory of Gene Expression

🔬Neurobiology and Developmental Biology | 🧬Single-cell and Spatial Transcriptomics | @KubistaMikael | @IBT_CAS @BIOCEV_science @CzechAcademy 🇨🇿🇪🇺

[Zuzana Matúšová @ZMatusova]

Happy to present our results at the Interdisciplinary meeting of young life scientists 2023 in the beautiful region of Žďárské vrchy! #milovy #science #conference

[Laboratory of Gene Expression @labgenex]

We did a thing!
"Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity"
👉 https://t.co/zk68vJ8FUB
Exciting data published in @jclinicalinvest
Swedish-German-Czech collaboration🥂
@CzechAcademy @IBT_CAS

[Lukas Valihrach @LukasValihrach]

So happy to see this published in @jclinicalinvest!🥳🥂

Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity
👉https://t.co/Ob2qlXQjY8

@uniofgothenburg @UKKoeln @CzechAcademy @IBT_CAS 🇸🇪🇩🇪🇨🇿 🧵1/8

[Laboratory of Gene Expression @labgenex]

New paper published in our lab!
➡️ Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology
➡️ https://t.co/8F15Ys6XLD
Great collaboration with Mirka Anderova group from IEM CAS🧠 Congrats to @ZMatusova @LukasValihrach and all authors involved👍

[Lukas Valihrach @LukasValihrach]

Happy to share our latest contribution to #ALS research🥳
Cortical glia in SOD1(G93A) mice are subtly affected by ALS-like pathology🧠
👉 https://t.co/eLsRBvNgGd
#scRNAseq #astrocytes #microglia #oligodendrocytes @labgenex @IBT_CAS @BIOCEV_science 🧵1/5

[Microgenomics-2023 @Microgenomics2]

Would you like to participate in @KubistaMikael workshop course on #methods & #strategies for #biomarker analysis? Take a look at the program & register today! https://t.co/qzLxOoBtHP

[Laboratory of Gene Expression @labgenex]

👇Happy to share our new review 👇

Reactive astrogliosis in the era of single-cell transcriptomics
➡️ https://t.co/qvoNCSVobq

Nice collaborative effort with @elly_hol🇳🇱 and Milos Pekny🇸🇪
#astrocytes #scRNAseq @IBT_CAS @BIOCEV_science

[Lukas Valihrach @LukasValihrach]

Analyzing reactive astrocytes with scRNA-seq and need help with annotation and interpretation? Check our new minireview 👉https://t.co/Be2l57GSTP
Together with leading experts in astrocyte biology, we reviewed signatures of reactive astrogliosis across multiple CNS disorders🧵1/4

[Laboratory of Gene Expression @labgenex]

Congratulation to our teammates @ZMatusova and @DanielZucha for outstanding representation of our lab! 👏👏🥳
Also big thanks to the organizers for preparing such great event👍👍 Looking forward to the next one😉
@IBT_CAS @BIOCEV_science

[Lukas Valihrach @LukasValihrach]

Super-super proud of my two excellent PhD students, who received BEST TALK and BEST POSTER AWARDS at the first PhD student conference at @IBT_CAS and @BIOCEV_science 🥳👏🥳
Congrats and big applause for @ZMatusova and @DanielZucha from @labgenex 1/2🧵

[Laboratory of Gene Expression @labgenex]

Another successful project between @PavlinkovaLab and @labgenex just published in Cardiovascular Diabetology👇
Dysregulation of hypoxia-inducible factor 1α in the sympathetic nervous system accelerates diabetic cardiomyopathy
https://t.co/3b4nsGwtHe
@IBT_CAS @BIOCEV_science

[Laboratory of Gene Expression @labgenex]

Back to Basics...
Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action
👉 https://t.co/bHa901ZyCG
@KubistaMikael @IBT_CAS @BIOCEV_science

[Laboratory of Gene Expression @labgenex]

🚨Preprint alert🚨
Proud to present this new study from our lab😆
Characterization of regeneration initiating cells during Xenopus laevis tail regeneration🐸
👉 https://t.co/GouIpVftwc
@IBT_CAS @BIOCEV_science #scRNAseq #spatialtranscriptomics #Xenopus #regeneration #RICs

[Laboratory of Gene Expression @labgenex]

🚨Preprint alert🚨
Very excited to share a new piece from our lab
🧠 Spatiotemporal transcriptomic map of ischemic brain injury
👉 https://t.co/fpYPFVkR3U
@DanielZucha @LukasValihrach @AbaffyPali @kirdajka @IBT_CAS @BIOCEV_science

[Daniel Žucha @DanielZucha]

Dear Twitter,
We are thrilled to share with you our most recent work - Spatiotemporal transcriptomic map of ischemic brain injury 🧠🤯 We looked at the first week of the injury, and we invite you to join us. A short thread🧵on what we found… 👇 https://t.co/J6BCQqteou

[Lukas Valihrach @LukasValihrach]

Thanks @IBT_CAS for highlighting our research😉
....and stay tuned. We are just drafting our flagship manuscript providing brand new perspective on #AlexanderDisease pathology. More coming soon😉 @labgenex @rarediseaseday

[Lukas Valihrach @LukasValihrach]

👇happy to contribute to this study👇
β‐Lactoglobulin affects the oxidative status and viability of equine endometrial progenitor cells via lncRNA‐mRNA‐miRNA regulatory associations https://t.co/QlqBoOJdZR
Congrats to authors and special thanks to Agnieszka😉@labgenex @IBT_CAS

[Mikael Kubista @KubistaMikael]

https://t.co/J7SKopILTW

[Mikael Kubista @KubistaMikael]

https://t.co/it1BrePgN4

[Elly Hol @elly_hol]

There is an open call for post-doc fellowships (ZonMW dementia research). If you are interested in astrocyte-neuron interactions in dementia, have defended your thesis less than 5 years ago, and would like to work in my lab for 3 years...see https://t.co/mMf1tIqWc8 or DM me.

[Laboratory of Gene Expression @labgenex]

Well done👍 Congrats to all authors👏

[Lukas Valihrach @LukasValihrach]

👇So proud and happy to see this published 👇
ISL1 controls pancreatic alpha cell fate and beta cell maturation https://t.co/nkG6uSyH9e
Great collaboration with @PavlinkovaLab and our first experience with CUT&Tag-seq🧬🥳
@labgenex @IBT_CAS @BIOCEV_science

[Lukas Valihrach @LukasValihrach]

Happy to contribute to this wonderful study “Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration” https://t.co/Ht0LJH59ab and looking forward to next joint projects with Dasa Bohaciakova lab https://t.co/Ht0LJH59ab 🧵1/3

[Institute of Biotechnology @IBT_CAS]

📝Still time to register for free @TATAA_CRO webinar on #qPCR and #dPCR led by @KubistaMikael
@BIOCEV_science @CzechAcademy @labgenex
#cellandgenetherapy #scienceeducation
⬇️⬇️⬇️

[Lukas Valihrach @LukasValihrach]

Thanks to @BIOCEV_science to highlight our work😊👍 Also thanks for all the support from @IBT_CAS and #GACR👏
@labgenex #miRNA #SCI
👇Scientists are looking for new ways to regenerate nerve tissue using microRNA molecules👇 https://t.co/yAoLnmX3dj

[Lukas Valihrach @LukasValihrach]

Very excited and happy to be awarded two #GACR grants to study experimental ischemic brain injury with #singlecell and #spatial #transcriptomics🥳🥂
@labgenex @IBT_CAS @BIOCEV_science
https://t.co/K9am7gtptG