Polyak Lab

The official Kornelia Polyak Lab Twitter account. The Polyak Lab @DanaFarber Cancer Institute is dedicated to the molecular analysis of human breast cancer.

[Polyak Lab @LabPolyak]

@DFCI_BreastOnc @DanaFarberNews @CFCE_DanaFarber @JCarrollLab @BalkoLab @Malvina_Pap @BroadProteomics

[Polyak Lab @LabPolyak]

Our study on histone tail cleavage is out today in @NatureGenet . We found KDM4C prevents CTSL-mediated histone H3 tail clipping by modulating its recruiter GRHL2, reducing oxidative stress and promoting basal tumor growth. Congrats to @ZheqiL @nellage
https://t.co/Lllx8afviz

[Polyak Lab @LabPolyak]

We are thrilled to see our study about ZBTB7A in basal breast cancer is out in @CellReports . We identified ZBTB7A as an novel interactor and regulator of KDM5 using CRISPR screen, and characterized its functional impact on NFkB pathway. Congrats to all!

[Cell Reports @CellReports]

ZBTB7A is a modulator of KDM5-driven transcriptional networks in basal breast cancer https://t.co/VMpADBkn6m

[Polyak Lab @LabPolyak]

🎃Polyak lab is getting ready for the MCO halloween pumpkin decoration contest! Huge shoutout to @MarieAnneGoyet1 and Andriana who made this piece of work based on the lab logo! Science and creativity go hand in hand!

[Polyak Lab @LabPolyak]

@DFCI_BreastOnc @DanaFarberNews @DanaFarber

[Polyak Lab @LabPolyak]

We're excited to share that our study on aging has been published today in @Cancer_Cell. We used rat model to identify midkine as a promising driver in breast cancer tumorigenesis. Kudos to all the coauthors especially @yan_pengze !
https://t.co/JbhfVd9xiM

[Pengze @yan_pengze]

Thrilled to share that my aging and breast cancer paper is now published in Cancer Cell! 🎉 In this study, we identified “Midkine” as a key factor linking aging with cancer. @LabPolyak Check it out! #CancerResearch #BreastCancer #Aging https://t.co/FYAOXAmVlD

[Polyak Lab @LabPolyak]

@nellage @ZheqiL @MarieAnneGoyet1 @CFCE_DanaFarber @DFCI_BreastOnc @DanaFarberNews

[Polyak Lab @LabPolyak]

Thrilled to see our paper on KMT2C/2D in TNBC metastasis is out today in @NatureCellBio. We found loss of KMT2C/2D promotes brain metastasis via KDM6A actviation and MMP3 upregulation. Congrats to our twitterless Marco and all the coauthors!
https://t.co/ZL95p9HZ0i

[Polyak Lab @LabPolyak]

Our study characterizing breast cancer brain metastasis is officially out in @PNASNews. We reproted breast cancer-stromal cells interaction induces resistance to HER2-targeting agents via bulky glycoproteins. Congrats to @MarieAnneGoyet1 and @nellage.
https://t.co/adB0G5dm80

[Polyak Lab @LabPolyak]

We are thrilled to announce that Nelly has been elected as a member of the prestigious American Academy of Arts and Sciences. Congratulations! We're so very proud of you!@nellage @DanaFarber @DanaFarberNews

[Polyak Lab @LabPolyak]

@DFCI_BreastOnc @DanaFarberNews @nellage @ZheqiL @Otto_DFCI @MarieAnneGoyet1 @CarlosArteagaMD @TariKingMD @jenniferbellon2 @DrEricWiner

[Polyak Lab @LabPolyak]

We are pleased to share our Phase II T-DM1+Pertuzumab clinical trial paper is online in @jclinicalinvest today. Tumors w/ or w/o HER2 heterogeneity show distinct modes of response and resistance towards anti-HER2 agents.
https://t.co/J74iUlJuv1

[Polyak Lab @LabPolyak]

@IBC_DanaFarber @DFCI_BreastOnc @DanaFarberNews @nellage @FilipaLynce @EMittendorfMD @stolaney1 @ZheqiL @DrEricWiner @TariKingMD @janebrockmd @BalkoLab

[Polyak Lab @LabPolyak]

We are thrilled to see our IBC clinical trial study is officially out in @BCRJournal. We found the use JAK1/2 inhibitor Ruxolitinib in TN-IBC resulted in decreased pSTAT3 but lack of clinical benefits. Comb with immunotherapy may need to be considered.
https://t.co/ZavUA4kW48

[Polyak Lab @LabPolyak]

Our resource paper on TNBC omic is officially out in @CellReports. We dissected TNBC heterogeneity with deep multiomic profiling on 34 TNBC cell lines and identified drivers of TNBC classification. Congrats to all! @nellage
https://t.co/xRonOMtB3W

[Polyak Lab @LabPolyak]

@DanaFarberNews @DFCI_BreastOnc @nlinmd @AnnPartridgeMD

[Polyak Lab @LabPolyak]

Our TCR study is officially out today in @PNASNews. Congrats to all the coauthors @simocristea @nellage and #twitterless Jun. We found peripheral blood TCR clonotype diversity is associated with age and intratumor immune in breast cancer patients.
https://t.co/47SOXV4DDp

[Polyak Lab @LabPolyak]

Congrats Nelly for receiving the 2023 #AACR Distinguished Lectureship in Breast Cancer Research Award! We take immense pride in this remarkable achievement, and we remain dedicated to our ongoing efforts in the fight against breast cancer.

[Dana-Farber’s Breast Oncology Center @DFCI_BreastOnc]

Dr. Kornelia P_olyak, a @DanaFarber leading basic and translational scientist in #breastcancer research, is the recipient of the 2023 #AACR Distinguished Lectureship in Breast Cancer Research Award, which will be presented at #SABCS23. @LabPolyak @nellage
https://t.co/9MoMWcOELA

[Polyak Lab @LabPolyak]

Our preclinical study evaluating the efficacy of BRD4 inhibitor+Paclitaxel+anti-PD-L1 combination for TNBC is out in @MCT_AACR today. Congrats to all the coauthors! And of course a lot more to be explored in the future. @nellage
https://t.co/0iHUfXRP6e