PomboLab

Genome, genes, regulation @BIMSB_MDC

[PomboLab @LabPombo]

What are the molecular effects of a single drug exposure 💉 on reward system #dopamine neurons 🧠?
We found an unexpected role of 3D genome 🧬 structure in long-term cellular memory of a single #cocaine exposure.
@domSzabo @vedranfranke @WarrenWinick @apombo1 @BIMSB_MDC
1/6

[bioRxiv @biorxivpreprint]

A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons https://t.co/GbTbgTPmfA #bioRxiv

[PomboLab @LabPombo]

@srinjan_basu Thank you Srinjan

[PomboLab @LabPombo]

@eleanorjpaul @batxes @samdemharter @lunazere9 @JPLopezAtalaya @MarioNicodemi @AltunaAkalin @KhodosevichLab @MarkU65668 Simona Bianco, Mykahilo Batiuk, Alexander Kukalev, Ulrich Pfisterer, Andrea Chiariello.
Thanks to our funders 💰 for supporting the work @BIMSB_MDC
@MDC_Berlin @helmholtz_de @4DNucleome @FEBSnews @neurocureberlin @dfg_public @novonordiskfond @LFINetwork @DonnellyCentre

[PomboLab @LabPombo]

What are the molecular effects of a single drug exposure 💉 on reward system #dopamine neurons 🧠?
We found an unexpected role of 3D genome 🧬 structure in long-term cellular memory of a single #cocaine exposure.
@domSzabo @vedranfranke @WarrenWinick @apombo1 @BIMSB_MDC
1/6

[bioRxiv @biorxivpreprint]

A single dose of cocaine rewires the 3D genome structure of midbrain dopamine neurons https://t.co/GbTbgTPmfA #bioRxiv

[PomboLab @LabPombo]

This has been a fantastic collaboration involving people across countries 🇩🇪🇬🇧🇩🇰🇮🇹🇨🇦🇪🇸, continents 🌍 🌎 and fields of expertise 🐭💉🧬🔬🖥️. Many thanks to @eleanorjpaul @batxes @samdemharter @lunazere9 @JPLopezAtalaya @MarioNicodemi @AltunaAkalin @khodosevichLab @MarkU65668

[bioRxiv @biorxivpreprint]

Extensive folding variability between homologous chromosomes in mammalian cells https://t.co/7fHArXRQRo #bioRxiv

[Ibai Irastorza @batxes]

I am very pleased to share that our latest research🧑‍🔬 from @LabPombo, about allele-specific chromatin structure 🧬, now live on bioRxiv.
Shout out to @apombo1, Alexander Kukalev, Rieke Kempfer and the rest of the team for this remarkable work of science.

↓ Short thread below ↓

[Mitch Guttman @mitchguttman]

What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. https://t.co/8KwfJHQWTt

[PomboLab @LabPombo]

🌱A huge thanks to the @Co_Biologists and to all the reviewers involved on planting our paper as a cherry blossom tree @For_Biologists 🌸 5/5

[PomboLab @LabPombo]

Our paper uncovering the role of SRRM2 splicing factor in stem cell pluripotency is published @BiologyOpen!

🚀 Huge joint effort coming from @LabPombo @BioComicsLab @Silviacamoeira @apombo1 @BIMSB_MDC @UCIBIO_Research @FCTNOVA

https://t.co/dy0GsNpF86
↓ Short thread below ↓

[PomboLab @LabPombo]

Splicing alterations precede gene expression events and morphological changes 4/5

[Mareike Albert @MareikeAlbert]

Incredibly excited that the DFG is establishing a priority programme in #neuroepigenetics. Initiative lead by Tanja Vogel with support from @BenschZimmer, André Fischer, @apombo1 and myself. Looking forward to great science to emerge from #EPIADAPT!

https://t.co/woqcea3RgG

[Elena Torlai T @ele_tt]

Thanks for the warm welcome these past weeks @QMULepigenetics! What an amazing community to be a part of 🤩🧬👨‍🔬👩‍💻