Sonawane Lab

Our lab studies the molecular mechanisms of Mtb pathogenesis and its different host immune evasion mechanisms and attempts new targeted therapy for tuberculosis

[IIT Indore @IITIOfficial]

Congratulations to Prof. Avinash Sonawane for being awarded National Bio Entrepreneurship Award 2021 in Drug Development and Health Care category. @EduMinOfIndia

[C-CAMP @CCAMP_India]

Presenting 17 Winners of CCAMP @BIRAC_2012 #NBEC2021 under Startup/ Innovator category!

Will take home total loot of ₹8.5+Cr in Cash Prizes & Investment opportunities!

#Medtech #Agri #WATSAN #Diagnostics #DrugDiscovery #IndustrialBiotech
@rajesh_gokhale @drashwathcn @kiranshaw

[Sonawane Lab @LabSonawane]

@soumohanty1987 @J_A_C_S @LabMalkoch @karolinskainst @KTHuniversity A big congratulations to @soumohanty1987 and everyone involved in the study. Significant work with strong clinical relevance in future against many drug resistance bacteria.

[Sonawane Lab @LabSonawane]

Mycobacterium tuberculosis inhibits autophagy by inducing histone hypermethylation in autophagy-related genes to promote intracellular bacterial survival. https://t.co/2FRxBSdBqW
@FrontiersIn

[Sonawane Lab @LabSonawane]

Very impressive work. This will certainly help to understand the complexity of granuloma. Congratulations to all authors. @ashwanikumarlab @Pc65405792

[Nature Communications @NatureComms]

Mycobacterium tuberculosis forms biofilms during infection in animal models & in TB patients.

Biofilm formation contributes to virulence and drug tolerance

@ashwanikumarlab @Pc65405792 @SapnaBajeli @director_imtech @CSIR_IMTECH

https://t.co/nZ6Z7zTBPf

[Sonawane Lab @LabSonawane]

20 Years of TRPV4 – Exploring Science, Discovery, and Future Directions
Virtual Conference: June 8 – 11, 2021

https://t.co/c3Yv73LEO1

[Sonawane Lab @LabSonawane]

M-ASPAR asparaginase developed in our laboratory at IIT Indore to enter phase I and II clinical trials for blood cancer treatment

[Sonawane Lab @LabSonawane]

We are happy that a cost effective asparaginase (enzyme used for the treatment), MASPAR developed by us using protein engineering approach to treat acute lymphoblastic leukemia is ready to enter phase-1 clinical trial. @IITIOfficial @ACTREC_TMC
https://t.co/31hT3zTFWX

[Sonawane Lab @LabSonawane]

Our recent study highlights the role of Mtb EsxL in regulation of TNF-α secretion via TLR2 mediated activation of NF-κB and MAPK signalling in murine macrophages. @ImmunologyNews @IITIOfficial @BSBE_IIT_Indore

https://t.co/9PDVmSxfZW

[Sonawane Lab @LabSonawane]

Many congratulations Amit. Very nice work.

[Amit Singhal @Lab_AmitSinghal]

Happy to share our recent work on dissecting the effect of metformin on CD8+ T cells, towards our understanding of its anti-TB activity. Great collaboration with @EvNewell1, Hardy Kornfeld & others 🙂

https://t.co/fsIPK1VyIK

[Sonawane Lab @LabSonawane]

@k2b_kuntal @shekhar_mande @MandeSharmila @TCS @TCSinnovation @inaehq1 Congratulations Dr.Mande

[Sonawane Lab @LabSonawane]

Our research work on TRPV4 as a host directed therapeutics for the treatment of Tuberculosis has been covered by scientific magazine @DrugTargetRev .
https://t.co/ImEZRVPxjq

[Mycobacterium Papers @MycobactPapers]

Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Lat... https://t.co/n5BUjUZXN8

[iScience journal @iScience_CP]

Differential roles of the calcium ion channel TRPV4 in host responses to Mycobacterium tuberculosis early and late in infection https://t.co/pLH3Of621W

[Sonawane Lab @LabSonawane]

@VivekRaoigib @IGIBSocial Host directed therapy and Re-Purposing drugs are indeed the way to move forward in dealing Tuberculosis. Good work by the authors.

[Sonawane Lab @LabSonawane]

@doctorsoumya @MoHFW_INDIA @pallavabagla @sciencecohen @IAPartnership @ICMRDELHI @trevormundel @DBTIndia @davidnabarro Great

[Sonawane Lab @LabSonawane]

Here is our latest article in collaboration with Schaible Group @FZBorstel entitled "Differential roles of the calcium ion channel TRPV4 in host responses to Mycobacterium tuberculosis early and late in infection". @iScience_CP @IITIOfficial
https://t.co/Yl3mjLiarX