Ilya Lagutin

digital bear

[Turner Novak 🍌🧢 @TurnerNovak]

Uber employees using $100k of Claude tokens to respond to an email

[Alex Fedotoff @FedotOff90]

Got connected to a 33-year-old Saudi guy through our WhatsApp community who sells collagen supplements across the Gulf region.

$1.8M/month across Saudi Arabia, UAE, Kuwait, and Bahrain.

One product. One funnel. Arabic-language ads.

He told me something that completely reframed how I think about the Middle East:

"Americans think of the Gulf as one small market. It's not. Saudi alone is 36 million people with the highest beauty spending per capita in the region. The combined Gulf states are 60 million people with more disposable income than most European countries."

His CAC across the Gulf: $18 on a $95 AOV product.

Saudi Arabia's ecom market hit $31 billion in 2026 and is growing at 12% annually. 99% internet penetration. 78% 5G coverage. The government's Vision 2030 initiative is literally building the infrastructure to make ecom easier — better logistics, faster payments, customs reform.

He runs the ads himself. Has a customer service team in Riyadh and a 3PL in Jeddah. Total team: 5 people.

His advice: "If you can get Arabic translation right — and I mean RIGHT, not Google Translate — the Gulf market will print for you. The spending power here is unreal and the competition from Western DTC brands is almost zero."

If you have Arab friends or family — put them on this. The Gulf ecom market is growing at double digits and almost nobody from the Western DTC world is there yet.

[Alessandro Palombo @thealepalombo]

Cyprus is one of the strongest European options right now. My honest view: 80% of mobile families will end up here. And many will pair it with Asian-based asset and company structures.

No other jurisdiction offers this flexibility.

The non-dom regime lasts 17 years. 0% on foreign-sourced income for the entire duration, extendable. Corporate tax is 15%, but holding structures frequently pay 0% tax and 0% withholding tax. Main cost in practice: healthcare contribution on certain income caps, capped at roughly €4.7k/year.

No more flexible European residency exists. 60-day rule for tax residency, now compatible with second tax residencies. You can keep Cyprus as a base while living nomadically.

Golden Visa from €300K. Citizenship after 8 years, or as few as 4 to 5 for highly skilled professionals on the fast-track. Underrated. One of the most accessible EU passport pathways available.

Crypto structuring requires care, but that should be part of any planning exercise regardless.

When NHR ends for many in Portugal, Cyprus will be the natural European pivot, and Thailand the more obvious Asian base. I'm working on a technical case study with local practitioners, plus a lifestyle post.

For families with kids, best towns in Cyprus: Limassol, Paphos, others? Which would you recommend? Pros and cons?

[Ilya Lagutin @lagutin]

How to to Generate a 360° DNA Analysis Report

## How to use this

1. Go to **Claude** (https://t.co/AgPdSD2IMD or Claude desktop app with Cowork mode)
2. Upload your **23andMe raw data file** (the .txt file you download from 23andMe → Settings → 23andMe Data → Download Raw Data)
3. Paste the prompt below into the chat

---

## The Prompt

```
I want you to act as a DNA researcher and genomic analyst. I've uploaded my 23andMe raw genotype data file.

Please perform a comprehensive 360° genetic analysis and generate a professional PDF report. The report should include:

### PART 1: 360° LIFE PROFILE (10-15 genetically-backed traits per section)

1. **ME AS AN ENTREPRENEUR & LEADER** — cognitive strengths (COMT, BDNF), decision-making style (DRD2), stress response, social intelligence (OXTR), energy/metabolism (FTO, CYP1A2), risk tolerance, focus capacity, burnout vulnerability

2. **ME AS AN ATHLETE & SPORTSMAN** — muscle fiber type (ACTN3), injury risk (COL1A1), body composition (FTO), recovery profile (IL-6, IL-10), pain tolerance (OPRM1), caffeine as ergogenic aid (CYP1A2), endurance vs power balance, best-suited sports

3. **ME AS A LOVER & PARTNER** — bonding/attachment style (OXTR), emotional intensity (COMT), reward system (DRD2, OPRM1), empathy, emotional resilience (BDNF), physical traits/appearance (HERC2, MC1R, SLC45A2, SLC24A5)

4. **MY MENTAL HEALTH & PSYCHOLOGICAL RESILIENCE** — anxiety predisposition (COMT), depression vulnerability (BDNF, IL-6), addiction resistance (DRD2, OPRM1), social resilience (OXTR), neuroinflammation (CRP), cognitive longevity (APOE)

5. **MY LONGEVITY & AGING TRAJECTORY** — Alzheimer's risk (APOE), cardiovascular aging (9p21), metabolic aging (TCF7L2, FTO), inflammaging profile (IL-6, IL-10), skin aging (MC1R), DNA repair capacity (MTHFR), detoxification (NQO1, GSTP1)

6. **MY NUTRITION & METABOLIC BLUEPRINT** — caffeine metabolism (CYP1A2), lactose tolerance (MCM6/LCT), folate processing (MTHFR), B12 utilization (MTRR), vitamin D levels (GC/VDBP), iron absorption (HFE), inflammatory response to food (IL-6), ideal diet type

7. **MY SLEEP, RECOVERY & STRESS RESPONSE** — sleep quality factors (COMT, BDNF), caffeine-sleep interaction (CYP1A2), inflammatory recovery (IL-6, IL-10), melatonin production (MTHFR pathway), stress hormone regulation

8. **MY APPEARANCE, SKIN & PHYSICAL TRAITS** — eye color (HERC2, OCA2), skin pigmentation (SLC45A2, SLC24A5), hair color/texture (MC1R), skin cancer risk, photoaging, collagen quality (COL1A1)

9. **MY IMMUNE SYSTEM & DISEASE DEFENSE** — inflammatory control (IL-6, IL-10, TNF-alpha), antiviral response (IL28B), gut immunity (FUT2), detoxification enzymes (GSTP1, NQO1), immune cell production (MTHFR/B12)

10. **MY BODY ON MEDICATIONS (PHARMACOGENOMICS)** — statin response (SLCO1B1), warfarin metabolism (CYP2C9), drug metabolism (CYP2C19, CYP1A2), acetylation speed (NAT2), drug transport (ABCG2, ABCB1), opioid response (OPRM1)

### PART 2: PERSONALIZED ACTION PLAN

11. **GENETICALLY-OPTIMIZED EXERCISE PLAN** — weekly schedule based on muscle type, recovery profile, stress sensitivity, and cardiovascular needs

12. **GENETICALLY-TARGETED SUPPLEMENT STACK** — table with supplement name, genetic reason, dose, timing, and priority (HIGH/MEDIUM/OPTIONAL)

13. **MEDICAL CHECKUP CHECKLIST** — specific blood tests and screenings to request at next doctor visit, with frequency and target values, based on MY specific genetic variants

14. **TOP 10 GENETIC WEAKNESSES — RANKED** — from most impactful to least, with specific mitigation strategies for each

### PART 3: DETAILED TECHNICAL REPORT

Full SNP-level analysis with tables showing rsID, gene, genotype, interpretation, and risk level for each category.

### FORMAT REQUIREMENTS:
- Generate as a **PDF file** I can download
- Use color-coded risk levels (green = favorable, blue = normal, yellow/orange = moderate, red = elevated)
- Include colored section header bars
- Professional formatting with tables
- Include a disclaimer that this is for educational purposes only
- Each section of the 360° profile should have 10-15 specific genetically-backed traits with + (strength), ! (weakness), or = (neutral) indicators
- Include a "print this and bring to your doctor" note on the medical checkup page

Please analyze the uploaded file and generate the complete report.
```

---

## Notes

- This works best with **Claude Opus** in **Cowork mode** (Claude desktop app)
- The raw data file is typically named something like `genome_FIRSTNAME_LASTNAME_v4_Full_YYYYMMDD.txt`
- The analysis covers ~50+ well-studied SNPs across health, traits, and pharmacogenomics
- The report takes a few minutes to generate
- **This is NOT medical advice** — always consult a genetic counselor or doctor for clinical decisions

## What you'll get

A ~20-page professional PDF report covering every dimension of your life through the lens of your DNA, with actionable recommendations for exercise, supplements, and medical checkups personalized to YOUR specific genetic variants.

[Ilya Lagutin @lagutin]

JFK: Sending American troops to Vietnam is like taking a drink of whiskey: the first sip is easy, but the second and third are harder to stop.

[Elon Musk @elonmusk]

People giving OpenClaw root access to their entire life

[Ilya Lagutin @lagutin]

@sentientt_media Skills

[Data Veritas @data_veritas]

@RadioGenoa If Europeans were dinosaurs, they would vote for the meteor.

[Ben Lang @benln]

Y Combinator's 2026 request for startups:

[TBPN @tbpn]

Sequoia partner @sonyatweetybird says we're going from the age of product-led growth to the age of agent-led growth.

"You see this most clearly if you're using Claude Code actively. It says, 'Hey, for a database, you should use Supabase. For hosting, use Vercel.' It's choosing for you, the stuff you should be using."

"Product-led growth brought us closer to the vision of 'best product wins,' but ultimately people are still lazy. They can't read all the reviews, and they kind of default to what looks cool on the website."

"Whereas your agent has infinite time to go and make these choices for you. It can go and read all the documentation, read all the user comments, and figure out [what you need] for your use case."

[Ilya Lagutin @lagutin]

The Morning Star is read by people who think the country ought to be run by another country
The Daily Telegraph is read by people who think it is
Sun readers don't care who runs the country as long as she's got big tits.

[Ilya Lagutin @lagutin]

Brilliant characteristic of the audience of British newspapers from the Yes Prime Minister TV series:

The Daily Mirror is read by people who think they run the country
The Guardian is read by people who think they ought to run the country

[Ilya Lagutin @lagutin]

The Times is read by the people who actually do run the country
The Daily Mail is read by the wives of the people who run the country
The Financial Times is read by people who own the country

[Ilya Lagutin @lagutin]

@onlyblingbling1 @ricardogorski @robprogressive Less than in London

[Nick Davidov @Nick_Davidov]

btw an influx of ~50k Russians and Belarussians has made Cyprus the top 3 fastest growing economy in the Eurozone. Cyprus government has timely passed laws that allow Cyprus tech companies to hire and relocate Russians with minimal restrictions + lowered taxes for tech, resulting in multiple unicorns redomiciling there and bringing their employees.

[Elon Musk @elonmusk]

🚀

[Ilya Lagutin @lagutin]

We should be proud but not bound by our history.

[Ilya Lagutin @lagutin]

@mcuban Don't you think that issuing meme coins is a better way to earn money as a president than previous administration corruption?

[Collin Rugg @CollinRugg]

NEW: Mark Zuckerberg says the Biden administration would call META to scream and curse at them to censor *true* information on their platforms.

Holy sh*t.

Zuckerberg said the administration would call them and tell them to censor true information including a Leonardo DiCaprio meme about vaccine side effects.

"They pushed us super hard to take down the things that were honestly true... Anything that says that vaccines might have side effects, you basically need to take down."

Criminals.

[steveyun.ton @steveyun_ton]

TON is going to the US.