Among participants receiving monotherapy, an infecting pathogen with MIC of 2 mg/L was independently associated with both clinical failure (aOR 3.59 (1.10 – 11.77)) and 28-day mortality (aOR 3.22 (1.32 – 7.84)).
Among participants receiving combination therapy, no association was demonstrated between MIC and outcomes
🆕💥🟢Post-hoc analysis of the OVERCOME trial, clinical outcomes were worse if participants were infected with a pathogen where the colistin MIC was 2 mg/L compared to those where the MIC was ≤ 1 mg/L for treatment of CR GNB pneumonia and/or bloodstream infections. #idxposts
https://t.co/srY1k4kUq7
[POLÍTICA] Exclusivo de Juan Luis González en NOTICIAS: Grabois visitó a Peter Thiel, CEO de Palantir, en su mansión de Barrio Parque.
📸 @noticiasrevista
Have you ever heard of the Eagle effect?
When more kills less.
One of microbiology's most intriguing paradoxes: sometimes higher antibiotic concentrations result in less bacterial killing.
This phenomenon has even been proposed as a potential rationale for combination therapy.
the late β-lactam adjustment group (> 24 hours of sepsis recognition) was associated with reduced in-hospital mortality in an adjusted model (HR 0.588, 95% CI 0.355-0.974).
Link to pearl: https://t.co/FWvejPC5c5