Kwangwoon Lee

Assistant professor at The Ohio State University
Epigenetics & Protein engineering

[chris bahl @bahl_lab]

Every protein designer knows that producing & testing designed proteins is a foundational capability for our field, & this is still pretty challenging for a lot of folks. This is why I'm delighted to share our work to make high-throughput protein production more accessible.

🧵👇

[Kwangwoon Lee @Lee_biochemist]

@ZhipengA Cole lab reunion!

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! PIONEARing how DNA sequence composition tunes TF–nucleosome interactions https://t.co/qDDPk83aBm

[Zhipeng A. Wang @ZhipengA]

Excited to share our new paper in Current Protocols! As my first corresponding-author work, we present a systematic nucleosome- or histone-based deacylation assay for studying HDACs and sirtuins. Huge thanks to my team, the journal for the invitation, and yizhengillustration for

[NatureStructMolBiol @NatureSMB]

New online! DNA bendability regulates transcription factor binding to nucleosomes https://t.co/wiuBLPK8ck

[Zhipeng A. Wang @ZhipengA]

Excited to share our new nucleosome assembly method for asymmetric PTMs by a cyclic sortase, combined with middle-down proteomics! This could help solve many long-lasting biochemistry puzzles. Thanks to all the authors for their incredible contributions! https://t.co/81Nx7olzIC

[Cole Lab @Phil_Cole_Lab]

Ever wondered how histone modifications work together to regulate gene expression? In our recent study, we introduce cW11 sortase, an easy-to-use tool for dissecting the crosstalk between these modifications, both in vivo and in vitro!

[The Zhang Lab @ZhangLab_UT]

Thr4 phosphorylation in Pol II CTD is a "phantom mark," hidden until long after transcription ends! 👻 Our recent paper shows it's masked by nearby Ser5 phosphorylation, and we revealed it using a specific phosphatase.
Read more: https://t.co/3rkqrvcDlZ #Transcription

[Tianpeng Zhang @zhtianp2]

The Zhang Lab website is online now: https://t.co/oyZOlb7qxC. We are interested in Genome Integrity Maintenance within Repetitive Sequences.

[Kwangwoon Lee @Lee_biochemist]

@zhtianp2 Thanks, Tianpeng! And I'm really looking forward to your lab’s work on telomere research!

[Cole Lab @Phil_Cole_Lab]

How do combinatorial histone modifications impact gene expression? Our latest research aims to unravel this mystery. By engineering a mutant LSD1 enzyme (Y391K), we've disrupted the crosstalk between H3K4me and H3K14ac to explore its role in gene regulation. Check out our study!

[Zhipeng A. Wang @ZhipengA]

Hiring! Finally settling down in Miami and bye Boston! Ready for an exciting new journey. Seeking motivated postdocs for our new lab at the UMiami Miller School of Medicine, interested in protein epigenetics and chemical proteomics for cancer and aging. https://t.co/NwnK64DLiF

[Zhipeng A. Wang @ZhipengA]

Hiring! Seeking motivated postdocs, technicians, and graduate students for our new lab at the University of Miami Miller School of Medicine. Dive into protein chemistry and chemical proteomics to explore cancer and aging. #ZwangLab #UMiami #Research
https://t.co/NwnK64DLiF

[bioRxiv @biorxivpreprint]

Transferrin Receptor Targeting Chimeras (TransTACs) for Membrane Protein Degradation https://t.co/LUYlxWFtVS #bioRxiv

[McShan Lab @ Georgia Tech @mcshanNMR]

here's a digital copy of my ABCs book of protein structure and function (used as a children's book for outreach). recently submitted to the inaugural @ibbgatec art show <3.

https://t.co/Wv0a5RfRVG