Cole Lab

The trainee managed lab account for Phil Cole's Lab at the Harvard Medical School Department of Biochemistry and Molecular Pharmacology.

[Cole Lab @Phil_Cole_Lab]

Ever wondered how histone modifications work together to regulate gene expression? In our recent study, we introduce cW11 sortase, an easy-to-use tool for dissecting the crosstalk between these modifications, both in vivo and in vitro!

[J. Am. Chem. Soc. @J_A_C_S]

Circular Engineered Sortase for Interrogating Histone H3 in Chromatin | Journal of the American Chemical Society @WUSM_BMB @BrighamResearch @BrighamWomens @harvardmed #Engineered #Sortase #Histone #Chromatin https://t.co/djCMucPO0E

[Cole Lab @Phil_Cole_Lab]

Big thanks to our incredible team: @Lee_Biochemist, @MarcoBa35760773, @proteinnns, @HansJhanjie, @Eunju_Nam, Sarah Dubois-Coyne, Sam Whedon, @ZhipengA, Jonatan Caroli, Katherine Neal, Brian Ibeabuchi, @zuzerdhoondia, Mitzi I. Kuroda, @brian_b_liau, @BeckLab_Bigdata, @MatteviLab

[Cole Lab @Phil_Cole_Lab]

How do combinatorial histone modifications impact gene expression? Our latest research aims to unravel this mystery. By engineering a mutant LSD1 enzyme (Y391K), we've disrupted the crosstalk between H3K4me and H3K14ac to explore its role in gene regulation. Check out our study!

[Nature Chemical Biology @nchembio]

A new paper reports a mutant LSD1 that renders its nucleosome demethylase activity insensitive to Lys14 acetylation of histone H3, providing a tool to study the functional consequences of disconnecting histone modification crosstalk. Read it here https://t.co/qyFgxJ5h6P

[Zhipeng A. Wang @ZhipengA]

Hiring! Seeking motivated postdocs, technicians, and graduate students for our new lab at the University of Miami Miller School of Medicine. Dive into protein chemistry and chemical proteomics to explore cancer and aging. #ZwangLab #UMiami #Research
https://t.co/NwnK64DLiF

[Zhipeng A. Wang @ZhipengA]

Thrilled to announce I'll be starting my research lab this summer at the Desai Sethi Urology Institute & Sylvester Comprehensive Cancer Center, @umiamimedicine! A huge thanks to @NimaSharifiMD, @dipenjparekh & @DrSDNimer for their support. My aim is to develop novel chemical

[Cole Lab @Phil_Cole_Lab]

https://t.co/5Rpo4yBEQK

[Choudhary Lab CPR @ChoudharyLabCPR]

H3K27ac has been the go-to hallmark of enhancers for over a decade, but what if another chromatin feature exceeds this in predicting enhancers?
Our paper was just published @NatureGenet https://t.co/H3AVVDlE1m
Congrats to @TakeoNarita80, Yoshiki and the rest of the team.

[Cole Lab @Phil_Cole_Lab]

https://t.co/G0i2Ia7NZR

[J. Am. Chem. Soc. @J_A_C_S]

Semisynthetic Approach to the Analysis of Tumor Suppressor PTEN Ubiquitination @BrighamWomens @harvardmed @Harvard #Semisynthetic #TumorSuppresor #PTEN #Ubiquitination @BostonGlobe https://t.co/DQmEyg4qQJ

[Cole Lab @Phil_Cole_Lab]

https://t.co/No5eKTDiOM

[Maggie Chen @maggiechenchen]

Grateful to have had the opportunity to present my work at my first ever Gordon and brought back with me this piece of fancy paper (and some $ they say)! Learned about so much great science and made so many new friends! #BioorganicGRC

[Marty Taylor, MD PhD @DrMartyTaylor]

Really excited to share our collaborative story on LINE-1 in blood and tissue of cancer patients.
Pervasive and specific expression of LINE-1 starts early in cancer, with potential diagnostic, intervention, & monitoring opportunities across carcinomas.
https://t.co/kr6RaFD7kI

[Lucas Farnung @LucasFarnung]

🎉New Farnung lab paper in collab w/ @Phil_Cole_Lab! By using a chemical warhead, we catalytically trap SIRT6 on a nucleosome and visualize the nucleosome-SIRT6 structure by cryo-EM. Fantastic work by @MarkertJon, @ZhipengA, and Sam Whedon! https://t.co/qcDIcmb7CS