Liam Brown

Associate Principal Scientist at AstraZeneca, previously a researcher at the University of Oxford. Tweets/reacts/views are my own.

[Liam Brown @Liamaths]

@UberUKI_Support Hi, I have an issue with food that wasn't delivered. It seems there was an error in your system; my order is not in my order history but payment was taken. I would like a refund but support won't help as I have no order number. Should I issue a chargeback?

[Liam Brown @Liamaths]

Why did no patient respond to more than 3/9 peptides in a cancer vaccine for renal cell carcinoma?
My paper has been accepted into Immunotherapy Advances. We used a mechanistic model to test whether peptide off-rates from MHC-I could explain observations.
https://t.co/Kp2STxXnNr

[Liam Brown @Liamaths]

@hilseth_mistrov Exactly, but to propagate uncertainty of literature parameters, especially those less simple than anatomical parameters, we need uncertainty to be reported, which many authors don't do. The paper was a plea for us to report uncertainty, so in some ways, it preaches to the choir.

[Liam Brown @Liamaths]

A new paper of mine has been published.

As the title suggests, it's about how physiologically based model parameters are hard to uniquely determine, but surprisingly few studies publish parameter uncertainty, or identifiability analyses.

https://t.co/JzRVWpkfzl

[Liam Brown @Liamaths]

@hilseth_mistrov Thank you Hitesh, that's a good point, and one that we skirted near in the paper's discussion. In that paragraph we talked more about the identifiability of parameters in an ensemble of models, and how other authors may quote these parameter values divorced from their context.

[Liam Brown @Liamaths]

@ac_palmer This is a good approach, in my opinion. That you get confidence intervals, and your MCMC approach gives you a sense of parameter identifiability, means that you know the uncertainty in your parameter estimates, which is all that we advocated.

[Liam Brown @Liamaths]

@JoshuaABull @drkjjeffery @FloKlimm My advice would be to practise before starting a project. I created the tanks game through one of Unity's official tutorials ( https://t.co/LtXuVAlZh7 ) to learn C# first, then was able to learn how to use VR simply by looking through one of the example Unity projects from Leap.

[Liam Brown @Liamaths]

@sesiegler It's not ethical to kill animals unnecessarily, of course. Though I work 100% in silico myself, I think in vitro & in silico sadly can't be perfect; we need at least a little in vivo to test hypotheses & make sure we don't kill people. Thought that might be the reviewer thoughts

[Liam Brown @Liamaths]

@sesiegler I think the reviewers are uncomfortable with in vitro/silico models, regarding them as further from humans than in vivo models. Probably w/ good intentions. Remember 3Rs say "reduce" and "replace", not "remove". Could you appease w/ SOME in vivo supported by in vitro/silico?

[Liam Brown @Liamaths]

@sesiegler as promised

[Liam Brown @Liamaths]

Published! We quantified the anatomically-determined MAXIMUM delivery rate of CAR T-cells to tissues from blood. We find mouse delivery rates up to 10k-fold higher than humans, but typical doses only 100x less. Means many pre-clinic doses may be too high. https://t.co/kWWeUWCnWW

[Liam Brown @Liamaths]

Your current headline will reduce mask adherence among readers. But most studies recommend use of masks to protect others [3]. Please revise your headline!
[1] https://t.co/CZh0aSMBAO
[2] https://t.co/vm63HNLBCl
[3] https://t.co/QBGqqaFwXM

[Liam Brown @Liamaths]

@spectator Your headline [1] for Danish facemask study is misleading. The study shows that wearing a mask does not reduce transmission TO wearers. There was "no assessment of whether masks could decrease disease transmission from mask wearers to others" (quote) [2].

[Liam Brown @Liamaths]

@aliceschwarze I rather suspect the bird TV was more for the humans than the cat...

[Liam Brown @Liamaths]

@norabv139 @WadeMartinsLab @OxfordPDCentre @DPAGAthenaSwan @DPAGPostdoc @OxfordMedSci Was very happy to provide supporting information for this, given the fascinating context. Congratulations on the publication and the great work!

[Nora BV @norabv139]

The molecular tweezer CLR01 as an anti-aggregation therapy for Parkinson's! NatComs link below for full paper.

Great collaboration between @WadeMartinsLab at @OxfordPDCentre @DPAGAthenaSwan @DPAGPostdoc @OxfordMedSci , UCLA, Univ. Bordeaux, and UPV/EHU.

https://t.co/75r1F7oosl

[Liam Brown @Liamaths]

@sesiegler Your guess is as good as mine!

[Liam Brown @Liamaths]

@aliceschwarze pls respect cat tax and post a picture

[Mathsat @PodcastMathsAt]

And we are go
https://t.co/Hf1jo7LZfd

This week we offer a brand new dimension of Maths at:

You don't just have to listen to our mouths 👄, you can watch them as well 👀:

https://t.co/yJSd2Fijvo

We interview @JoshuaABull about where Gandalf should play in his Fantasy Team.