Check out our new paper on Nature showing that synonymous mutations are mostly strongly non-neutral. https://t.co/gKJCgP88DK with the accompanied News and views (https://t.co/d4sJGnTjSk). The first author is Xukang Shen, and corresponding author is my Ph.D. advisor George Zhang.
Incredible to see this out. A truly massive amount of work and an exciting discovery of the complex taxonomy of the tumor suppressor action. Congratulations to everyone but first and foremost to Hongchen Cai, Su Kit Chew, and @lichuan_Bio!! Congratulations!!
Ever wonder which tumor suppressor alterations impact drug responses in vivo? Check out our recent work on using improved Tuba-seq to quantify genotype-specific treatment responses in lung cancer. https://t.co/2sHPu2MqDd
I would like to thank my co-authors, special thanks to Wen-yang Lin who performed the mouse work, and Hira who collected clinical data, and my advisor Dmitri Petrov and Monte Winslow! You are the best!
@JoannaMasel Thank you for the suggestion. I will read that paper very carefully. From figure 1 (discussion), I think the fraction of events being nonadaptive will be higher for yeast.
My Ph.D. work with Dr. George Zhang about readthrough being nonadaptive in general is finally online. ^_^ #PLOSGenetics: Stop-codon read-through arises largely from molecular errors and is generally nonadaptive https://t.co/gHIWLtmCeI
So happy to be selected as an awardee for the Damon Runyon Fellowship! We will share more of our work on cancer growth and evolution in the future! https://t.co/KPE7R3fmDD
Extremely happy to report that @lichuan_Biohas been selected as one of the 2018 Damon Runyan Fellows! The first Damon Runyan Fellow in our lab as we are starting to focus on evolutionary biology on cancer growth more and more. https://t.co/4tVgK3aDIO
My new publication on multi-environment fitness landscapes of a tRNA gene: https://t.co/CjbLxMtwK5. ^_^ I will also do a presentation on this topic at the PEQG conference next month.