Heiko Lickert

Developmental and stem cell biologist, Professor for Beta Cell Biology @ TUM, Director of Institute for Diabetes and Regeneration @HelmholtzMunich Munich

[Heiko Lickert @LickertHeiko]

Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
https://t.co/GKx6eslJz0
A tremendous collaborative effort led by @JohannaSiehler, @BilekovaSara and other members of the @LickertHeiko lab.

[Heiko Lickert @LickertHeiko]

@elonmusknews30 A. Yes

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

Comparing Pancreas Development Across Species to Advance Diabetes Research 🧬

New insights from an international research team led by #HelmholtzMunich and the German Center for Diabetes Research (#DZD) could reshape the future of #diabetes modeling and #RegenerativeMedicine.

💡 Key finding: #Pancreas development in pigs mirrors humans much more closely than in traditional mouse models – from developmental tempo to gene regulation.

Using high-resolution single-cell and multi-omics analysis of over 120,000 pig pancreatic cells, researchers identified evolutionarily conserved gene networks and discovered a previously unknown primed endocrine cell (PEC) population – a potential source for regenerating insulin-producing beta cells.

💬 “Particularly for complex diseases such as diabetes mellitus, we need models that truly resemble humans.”
– Prof. Heiko Lickert, Director of the Institute of Diabetes and Regeneration Research, Helmholtz Munich

These findings could pave the way toward more precise translational models and ultimately causal diabetes therapies.

👉Learn more in our news: https://t.co/6WVUquRWju
🔗To the original publication: https://t.co/6abL30la90

@DiabResearch @LickertHeiko
#DiabetesResearch #RegenerativeMedicine #PancreasDevelopment #DZD #SingleCellAtlas

[Heiko Lickert @LickertHeiko]

Congratulations Nike, Nicole, Kathy and the whole team to get this important study into the pipeline. If you womder if stem cell-derived islet compositions matters for safety and efficacy of the graft, our tissue engineering approach gives an answer. Check it out….

[Nicole Katarina Rogers @RogersNicoleK]

I am very happy and excited to share that our work is out!! 🥳🤩 Grateful to the amazing @LickertHeiko lab members, collaborators, and mentors for their contributions and continuous support! 💪
https://t.co/zHSc04Qizv

[Rahul Satija @satijalab]

Our Single Cell Genomics Day - highlighting our favorite new sc/spatial methods - starts Friday at 10AM ET!

The most common question we get: is this open to anyone? Yes! Talks are free and live-streamed (no registration required) on Youtube and https://t.co/zG98gkckMU

[Dong-Jiunn Jeffery Truong @Earthnut89]

https://t.co/8Cwm3nmUzS
ENVLPE, our system for VLP-based delivery of gene editors, is now published in @CellCellPress. We showed efficient delivery of base- and prime-editors in primary T cells & in vivo retinal models.
Congrats co-first-authors @geilinho & @niggles293T!

[Heiko Lickert @LickertHeiko]

@Earthnut89 @CellCellPress @geilinho @niggles293T Great work, Jeff and Gil and the whole team - this works great and I am looking forward to new developments of you guys!

[CALL TO ACTIVISM @CalltoActivism]

Trump made a HISTORIC blunder during his speech while bragging he canceled $8 million in funding to turn Mice “transgender.”

The funding was for TRANSGENIC studies, where scientists introduce human disease cells like Alzheimer’s to study a cure. Unreal.

[Heiko Lickert @LickertHeiko]

Final count down…registration ends tomorrow…

[EMBO Events @EMBOevents]

Apply now for EMBO Workshop on Liver and pancreas in metabolic disease: from pathways to therapies 02 – 04 April 2025 in Sant Feliu de Guíxols (Girona), Spain

📜 Registration deadline: 14 February 2025
https://t.co/zD4HH0c35U

#EMBOliverPancreas

[FASEB @FASEBorg]

In her compelling op-ed published @Suntimes, @SocDevBio President Dr. Carole LaBonne warns that rapid innovation may not be suitable for science—where careful methodology, peer review, and sustained funding are key. If rushed, it risks breaking the very foundation of scientific progress. Read the full letter to understand why science needs stability. ⬇️⬇️

[Heiko Lickert @LickertHeiko]

Final chance to register is tomorrow…

[EMBO Events @EMBOevents]

Apply now for EMBO Workshop on Liver and pancreas in metabolic disease: from pathways to therapies 02 – 04 April 2025 in Sant Feliu de Guíxols (Girona), Spain

📜 Registration deadline: 14 February 2025
https://t.co/zD4HH0c35U

#EMBOliverPancreas

[Heiko Lickert @LickertHeiko]

So true, Alfonso! Hope we soon wake up again from this nightmare….who voted for this crazyness?!

[Alfonso Martinez Arias @AMartinezArias]

I went to the US in the late 1970s. I had heard so much about “America” and must say, it did live up to my expectations. I owe much to the US, not only my PhD. 🧵

[Heiko Lickert @LickertHeiko]

Exciting new tool to make the most out of multimodal single-cell data from our friends and long-term collaborators of the @fabian_theis lab - check it out, it works beautifully and really makes sense out of your complex data! 👇👍😉

[Fabian Theis @fabian_theis]

1/ Excited to see https://t.co/ezvTuR6WfH published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at https://t.co/ghCq7KgDtc

[Heiko Lickert @LickertHeiko]

Registration deadline is coming closer - make sure you do not miss this excellent EMBO workshop 😉

[EMBO Events @EMBOevents]

Apply now for EMBO Workshop on Liver and pancreas in metabolic disease: from pathways to therapies 02 – 04 April 2025 in Sant Feliu de Guíxols (Girona), Spain

📜 Registration deadline: 14 February 2025
https://t.co/zD4HH0c35U

#EMBOliverPancreas

[Alexander Bartelt @BarteltLab]

Today, we report that chronic intermittent fasting impairs beta-cell maturation & function in adolescent mice. Using scRNAseq, we delineated a maturation score for beta-cells. Long-term good if you're older, might be harmful if you are still developing!
👇
https://t.co/0dZu2LmVYv

[Alexander Bartelt @BarteltLab]

This collaborative project between @HelmholtzMunich, @TU_Muenchen, & @LMU_Muenchen was led by @LeonardoMatta, Peter Weber, & Suheda Erener - Big THX to @RohmMaria, @LickertHeiko et al. & the reviewers & editors @CellReports

[Heiko Lickert @LickertHeiko]

Congratulations Alex, team and partners!

[Alexander Bartelt @BarteltLab]

This collaborative project between @HelmholtzMunich, @TU_Muenchen, & @LMU_Muenchen was led by @LeonardoMatta, Peter Weber, & Suheda Erener - Big THX to @RohmMaria, @LickertHeiko et al. & the reviewers & editors @CellReports

[Nature Metabolism @NatMetabolism]

RESEARCH | @JohannaSiehler,@BilekovaSara, @LickertHeiko et al. (@HelmholtzMunich):

Inceptor (insulin inhibitory receptor) regulates #insulin stores by directing proinsulin and insulin towards lysosomal degradation.

https://t.co/mSL5vKAcaH

[EMBO Events @EMBOevents]

Apply now for EMBO Workshop on Liver and pancreas in metabolic disease: from pathways to therapies 02 – 04 April 2025 in Sant Feliu de Guíxols (Girona), Spain

📜 Registration deadline: 14 February 2025
https://t.co/zD4HH0c35U

#EMBOliverPancreas

[Heiko Lickert @LickertHeiko]

My top highlight for 2025 - EMBO workshop in Saint Feliu - three exciting days of science crossing boundaries of liver & pancreas research! Co-organised by @CebolaLab @1jorgeferrer @VallierLab @LickertHeiko & Emma Anderson #livertwitter #islets #masld #diabetes

[EMBO Events @EMBOevents]

Apply now for EMBO Workshop on Liver and pancreas in metabolic disease: from pathways to therapies 02 – 04 April 2025 in Sant Feliu de Guíxols (Girona), Spain

📜 Registration deadline: 14 February 2025
https://t.co/zD4HH0c35U

#EMBOliverPancreas

[Matthias Mann Lab @labs_mann]

China clearly sees the potential of proteomics and is about to place a gigantic bet on it; multi-billion dollar and 30 years!!! All the better for the advancement of science and health. We contributed to the white paper out now in @Nature
https://t.co/480tmOJQ3C