Linhua Sun

Bioinformatics & 3D Genome Research in Plants.

[Linhua Sun @LinhuaS]

@sciqst @TrendsPlantSci You can take a look at our recent work at PNAS, which has explored gene expression and development, although unfortunately, our work was not cited in this TIPS article. https://t.co/2QaTK60c7a

[Linhua Sun @LinhuaS]

New study in my lab.🙏

[Linhua Sun @LinhuaS]

Single-molecule views of chromatin accessibility and structure during photomorphogenesis | PNAS https://t.co/2QaTK60c7a

[Molecular Cell @MolecularCell]

EMF1 functions as a 3D chromatin modulator in Arabidopsis https://t.co/KYrllC0z0Z

[Linhua Sun @LinhuaS]

I am glad to publish another article (Molecular Cell) on the mechanism of plant 3D genome. Thank you! 🥂🥂🥂https://t.co/ohOYOPyFzy

[Molecular Cell @MolecularCell]

Online Now: EMF1 functions as a 3D chromatin modulator in Arabidopsis https://t.co/NWPk38NQfP

[Molecular Cell @MolecularCell]

Online Now: EMF1 functions as a 3D chromatin modulator in Arabidopsis https://t.co/NWPk38NQfP

[Linhua Sun @LinhuaS]

Mapping nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL https://t.co/veqes4ohD7

[Linhua Sun @LinhuaS]

This work is impossible without long-term support and guidance from Prof. Xing Wang Deng and Dr. Hang He👏👏👏.

[Linhua Sun @LinhuaS]

This study is the first to improve and apply Micro-C-XL in plants: a technique based on (Hi-C), using FA + EGS, and using MNase nuclease for cleavage, deciphering the chromatin structures with single nucleosome resolution, and applied it in Arabidopsis, rice, soybean.

[Linhua Sun @LinhuaS]

By integrating large-scale ChIP-Seq datasets of transcription factors and chromatin protein factors with large-scale short-range chromatin loops, it was identified that proteins such as MORC6/7, Pol V, and SYD may be involved in the formation and maintenance of chromatin loops.

[Linhua Sun @LinhuaS]

Meanwhile, unlike animal genomes, the length of protein-coding genes in plant genomes is relatively short, and there is an urgent need for high-resolution chromatin conformation capture techniques to systematically study the chromatin structures at the gene level.

[Linhua Sun @LinhuaS]

How to establish a connection between distant regulatory elements and PCGs? Years later, we finally achieved the nucleosome resolution of chromatin structures in plants through Micro-C-XL and attempted to elucidate their molecular mechanisms (https://t.co/QsJ8CTQMC3).

[Linhua Sun @LinhuaS]

In 2020, we published our first article on the 3D genomics of plants in Nature Communications. Since then, I have been left with many doubts. Hi-C with a resolution of 1kb cannot solve all problems, especially in analyzing transcriptional regulation. (https://t.co/wDSzWpszft)

[Linhua Sun @LinhuaS]

@Diagenode @Estelle_Plant_ @Van_Lint_lab You can contact me by [email protected]. I prefer Sales Partner in China.

[Linhua Sun @LinhuaS]

"SMARTdb: an integrated database for exploring single-cell multi-omics data of reproductive medicine" — Read it on @ResearchGate: https://t.co/DfPpnQOLBI

[Linhua Sun @LinhuaS]

Lab of Prof. Bian have established an online platform for reproductive medicine single cell multi omics (https://t.co/isx7MDLw2l). Covering the main time points throughout the entire life cycle, such as embryos, testes, ovaries, endometrium, and infertility.

[Linhua Sun @LinhuaS]

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